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  • 1
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    Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-11-07
    Description: Antibodies targeting CTLA-4 have been successfully used as cancer immunotherapy. We find that the antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species. In mice and patients, T cell responses specific for B. thetaiotaomicron or B. fragilis were associated with the efficacy of CTLA-4 blockade. Tumors in antibiotic-treated or germ-free mice did not respond to CTLA blockade. This defect was overcome by gavage with B. fragilis, by immunization with B. fragilis polysaccharides, or by adoptive transfer of B. fragilis-specific T cells. Fecal microbial transplantation from humans to mice confirmed that treatment of melanoma patients with antibodies against CTLA-4 favored the outgrowth of B. fragilis with anticancer properties. This study reveals a key role for Bacteroidales in the immunostimulatory effects of CTLA-4 blockade.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721659/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721659/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vetizou, Marie -- Pitt, Jonathan M -- Daillere, Romain -- Lepage, Patricia -- Waldschmitt, Nadine -- Flament, Caroline -- Rusakiewicz, Sylvie -- Routy, Bertrand -- Roberti, Maria P -- Duong, Connie P M -- Poirier-Colame, Vichnou -- Roux, Antoine -- Becharef, Sonia -- Formenti, Silvia -- Golden, Encouse -- Cording, Sascha -- Eberl, Gerard -- Schlitzer, Andreas -- Ginhoux, Florent -- Mani, Sridhar -- Yamazaki, Takahiro -- Jacquelot, Nicolas -- Enot, David P -- Berard, Marion -- Nigou, Jerome -- Opolon, Paule -- Eggermont, Alexander -- Woerther, Paul-Louis -- Chachaty, Elisabeth -- Chaput, Nathalie -- Robert, Caroline -- Mateus, Christina -- Kroemer, Guido -- Raoult, Didier -- Boneca, Ivo Gomperts -- Carbonnel, Franck -- Chamaillard, Mathias -- Zitvogel, Laurence -- R01 CA161879/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2015 Nov 27;350(6264):1079-84. doi: 10.1126/science.aad1329. Epub 2015 Nov 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Cancerologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France. INSERM U1015, GRCC, Villejuif, France. University of Paris Sud XI, Kremlin-Bicetre, France. ; Institut National de la Recherche Agronomique (INRA), Micalis-UMR1319, 78360 Jouy-en-Josas, France. ; University of Lille, CNRS, INSERM, Centre Hospitalier Regional Universitaire de Lille, Institut Pasteur de Lille, U1019, UMR 8204, Centre d'Infection et d'Immunite de Lille (CIIL), F-59000 Lille, France. ; Institut de Cancerologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France. INSERM U1015, GRCC, Villejuif, France. Center of Clinical Investigations in Biotherapies of Cancer 1428, Villejuif, France. ; Institut de Cancerologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France. INSERM U1015, GRCC, Villejuif, France. University of Paris Sud XI, Kremlin-Bicetre, France. Center of Clinical Investigations in Biotherapies of Cancer 1428, Villejuif, France. ; Institut de Cancerologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France. INSERM U1015, GRCC, Villejuif, France. Universite Paris Descartes, Sorbonne Paris Cite, Paris, France. ; Department of Radiation Oncology, New York University, New York, NY, USA. ; Microenvironment and Immunity Unit, Institut Pasteur, Paris, France. ; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. ; Department of Genetics and Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. ; Institut de Cancerologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France. Universite Paris Descartes, Sorbonne Paris Cite, Paris, France. Metabolomics Platform, GRCC, Villejuif, France. ; Animalerie Centrale, Institut Pasteur, Paris, France. ; Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale (IPBS), Toulouse, France. Universite de Toulouse, Universite Paul Sabatier, IPBS, F-31077 Toulouse, France. ; Institut de Cancerologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France. ; Institut de Cancerologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France. INSERM U1015, GRCC, Villejuif, France. Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France. ; Service de microbiologie, GRCC, Villejuif, France. ; Institut de Cancerologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France. Laboratory of Immunomonitoring in Oncology, UMS 3655 CNRS/US 23 INSERM, GRCC, Villejuif, France. ; Institut de Cancerologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France. Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France. INSERM U981, GRCC, Villejuif, France. ; Institut de Cancerologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France. Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France. ; Universite Paris Descartes, Sorbonne Paris Cite, Paris, France. Metabolomics Platform, GRCC, Villejuif, France. INSERM U848, Villejuif, France. Equipe 11 Labellisee-Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, INSERM U1138, Paris, France. Pole de Biologie, Hopital Europeen Georges Pompidou, Assistance Publique-Hopitaux de Paris, Paris, France. ; Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, Marseille, France. ; Institut Pasteur, Unit of Biology and Genetics of the Bacterial Cell Wall, Paris, France. INSERM, Equipe Avenir, Paris, France. ; University of Paris Sud XI, Kremlin-Bicetre, France. Gastroenterology Department, Hopital Bicetre, Assistance Publique-Hopitaux de Paris, Paris, France. ; Institut de Cancerologie Gustave Roussy Cancer Campus (GRCC), 114 rue Edouard Vaillant, 94805 Villejuif, France. INSERM U1015, GRCC, Villejuif, France. University of Paris Sud XI, Kremlin-Bicetre, France. Center of Clinical Investigations in Biotherapies of Cancer 1428, Villejuif, France. laurence.zitvogel@gustaveroussy.fr.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26541610" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Aged, 80 and over ; Animals ; Anti-Bacterial Agents/pharmacology ; Antibodies, Monoclonal/adverse effects/*therapeutic use ; Bacteroides/*immunology ; CTLA-4 Antigen/*antagonists & inhibitors/immunology ; Dysbiosis/immunology ; Fecal Microbiota Transplantation ; Female ; Gastrointestinal Microbiome/drug effects/*immunology ; Germ-Free Life/immunology ; Humans ; Immunologic Memory ; Immunotherapy ; Intestines/immunology/microbiology ; Male ; Melanoma/*therapy ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Skin Neoplasms/*therapy ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Predictors of responses to immune checkpoint blockade in advanced melanoma (2017)
    Springer Nature
    Details
    Publication Date: 2017-09-20
    Description: Predictors of responses to immune checkpoint blockade in advanced melanoma Nature Communications, Published online: 19 September 2017; doi:10.1038/s41467-017-00608-2 The clinical management of metastatic melanoma requires predictors of the response to checkpoint blockade. Here, the authors use immunological assays to identify potential prognostic/predictive biomarkers in circulating blood cells and in tumor-infiltrating lymphocytes from patients with resected stage III melanoma.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 3
    Electronic Resource
    Electronic Resource
    Viscous fingering in a magnetic fluid. II. Linear Hele–Shaw flow (2001)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 13 (2001), S. 3196-3203 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Viscous fingering phenomenon in a linear channel is studied for a magnetic fluid subjected to an external magnetic field. The competition between the hydrodynamic effects and the capillary effects leads to the formation of an interface between the air and the fluid which has a finger shape. It is the so-called Saffman–Taylor instability (STI). The influence of the magnetic effects depends on the direction of the applied field: it is possible either to enhance or to reduce the destabilizing phenomena. We study the onset of the STI and compare the experimental results with the linear analysis including the magnetic contribution. In the nonlinear regime, the measurement of the width of the finger as a function of the direction and the amplitude of the magnetic field is understood using a phenomenological approach. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1398041
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  • 4
    Electronic Resource
    Electronic Resource
    Viscous fingering in a magnetic fluid. I. Radial Hele-Shaw flow (1998)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 10 (1998), S. 2464-2472 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Viscous fingering phenomena in a circular geometry are studied for a magnetic fluid submitted to a perpendicular magnetic field. Air is injected at the center of a Hele-Shaw cell filled with a viscous magnetic fluid. The instability of the interface between the air and the magnetic fluid is favored by the presence of a magnetic field. More precisely, the threshold of the instability is magnetic field dependent. The patterns obtained for high values of the magnetic field with a low injection rate are similar to those obtained in the absence of an external field and at high flow rates. We also give a linear analysis for the stability of radial flow under the influence of a magnetic field. This calculation provides us with an understanding of the magnetic field effect. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.869765
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  • 5
    Electronic Resource
    Electronic Resource
    Nonequilibrium vibrational kinetics of carbon monoxide at high translational mode temperatures
    Amsterdam : Elsevier
    Chemical Physics 163 (1992), S. 241-262 
    Details
    ISSN: 0301-0104
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0301-0104(92)87106-J
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  • 6
    Electronic Resource
    Electronic Resource
    Phase diagram and morphology of anisotropic domains in a pure and mixed carbocyanine monolayer
    Amsterdam : Elsevier
    Thin Solid Films 244 (1994), S. 1026-1030 
    Details
    ISSN: 0040-6090
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0040-6090(94)90624-6
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  • 7
    Electronic Resource
    Electronic Resource
    Structure of an anisotropic two-dimensional solid in a Langmuir film studied by electron scattering
    Amsterdam : Elsevier
    Thin Solid Films 243 (1994), S. 411-414 
    Details
    ISSN: 0040-6090
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0040-6090(93)04100-7
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  • 8
    Electronic Resource
    Electronic Resource
    Surface waves in ferrofluids under vertical magnetic field (1999)
    Springer
    The European physical journal 9 (1999), S. 335-341 
    Details
    ISSN: 1434-6036
    Keywords: PACS. 75.50.Mm Magnetic liquids - 47.35.+i Hydrodynamic waves - 68.10.-m Fluid surfaces and fluid-fluid interface
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: We present here new experimental results about the waves at the horizontal free surface of a magnetic fluid submitted to a normal magnetic field. The waves are generated by a small modulation at frequency of the vertical field . Using a shadowgraph method, we are able to measure the wavevector k of the 2D waves for a given value of and . The dispersion relation of the surface waves is established experimentally. On the other hand, we propose a theoretical derivation of the dispersion equation which includes a more complete treatment of the magnetic term than the previous works. Finally, we conclude that a linear and inviscid analysis is sufficient to fit well the experimental data, except in the vicinity of the critical field where a surface instability occurs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100510050773
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  • 9
    Electronic Resource
    Electronic Resource
    Undulation instability in two-dimensional foams of magnetic fluid (1998)
    Springer
    The European physical journal 3 (1998), S. 203-209 
    Details
    ISSN: 1434-6036
    Keywords: PACS. 75.50.Mm Magnetic liquids - 46.30.Lx Static buckling and instability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: Two-dimensional magnetic fluid foams are cellular structures whose framework is made of magnetic fluid. The features of these equilibrated patterns are driven by a control parameter: the amplitude of the applied magnetic field. When the latter is rapidly increased, an instability occurs: the walls between cells undulate. Such an instability has also been observed in other 2D cellular structures, which exist for instance in Langmuir monolayers or in magnetic garnets thin films. In this paper we give a theoretical analysis of this instability, the issues of which are shown to be well confirmed by experiments and numerical simulations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100510050304
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  • 10
    Electronic Resource
    Electronic Resource
    The influence of four dietary proteins and sodium phytate on the metabolism of cholesterol and the lipoproteins in rat (1983)
    Springer
    Plant foods for human nutrition 33 (1983), S. 193-199 
    Details
    ISSN: 1573-9104
    Keywords: cholesterol ; dietary proteins ; lipoproteins ; phytate ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The hypocholesterolemic effect of dietary proteins could not be related to their vegetal or animal origin and seemed correlated to their different amino acids proportions. Comparing rats fed soy protein diet to those fed casein diet for 45 days, we observed a decrease of serum HDL cholesterol levels. Furthermore sequential centrifugation showed a decrease of HDL2–3 fraction and especially apolipoprotein E in the serum of soy protein fed rats. The sodium phytate, added to the diet, did not change the metabolism of sterols.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01091308
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