Publication Date:
1991-05-03
Description:
Genetic factors contribute to heart disease. In this study, linkage analyses have been performed in a family that is predisposed to sudden death from cardiac arrhythmias, the long QT syndrome (LQT). A DNA marker at the Harvey ras-1 locus (H-ras-1) was linked to LQT with a logarithm of the likelihood ratio for linkage (lod score) of 16.44 at theta = 0, which confirms the genetic basis of this trait and localizes this gene to the short arm of chromosome 11. As no recombination was observed between LQT and H-ras-1, and there is a physiological rationale for its involvement in this disease, ras becomes a candidate for the disease locus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keating, M -- Atkinson, D -- Dunn, C -- Timothy, K -- Vincent, G M -- Leppert, M -- New York, N.Y. -- Science. 1991 May 3;252(5006):704-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City 84132.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1673802" target="_blank"〉PubMed〈/a〉
Keywords:
Chromosome Mapping
;
Chromosomes, Human, Pair 11
;
Electrocardiography
;
*Genes, ras
;
Humans
;
*Lod Score
;
Long QT Syndrome/*genetics/physiopathology
;
Mutation
;
Pedigree
;
Polymorphism, Restriction Fragment Length
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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