ISSN:
1075-2617
Keywords:
Nformylmethionyl peptides
;
human neutrophils
;
chemotaxis
;
superoxide anion generation
;
lysozyme release
;
Chemistry
;
Biochemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The formylpeptides formyl-methionyl-Nmethylleucyl- phenylaline methyl ester [for-Met-(NMe)Leu-Phe-OMe] 1, formyl-methionyl-2-aminotetralin-2-carboxyl-phenylalanine methyl ester [for-Met Act-Phe-OMe] 2, formyl-methionyl-1,2,3,4-terahydroisoquinoline-3-carboxl- phenylalanine methyl ester [for-Met-Tic-Phe-OMe] 3 and formyl- methionyl-2-aminoxy-4-methylvaleryl-phenylalanine methyl ester [for-Met-OLeu-Phe-OMe] 4 were synthesized in order to investigate the role of the amide bond at position 2 on biological activities on human neutrophils. Only analogue 2, which keeps the NH group at position 2, was found to retain activity though sterically encumbered.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/psc.55
Permalink