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  • 1
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    Clinical features and outcome of children with first marrow relapse of acute lymphoblastic leukemia expressing BCR-ABL fusion transcripts. BFM Relapse Study Group (1996)
    American Society of Hematology
    Details
    Publication Date: 1996-02-15
    Description: Although the Philadelphia chromosome (Ph1) has been identified as an adverse prognostic factor in acute lymphoblastic leukemia (ALL), little is known about the incidence and clinical course of relapsed Ph1- positive ALL in children. The incidence was determined by screening of 170 consecutive children with first bone marrow relapse of ALL using the reverse transcriptase-polymerase chain reaction (RT-PCR) and comparison, with cytogenetic analysis. Among these 170 children, 20 (12%) were found to be BCR-ABL-positive, representing a rate that is about three times higher than that reported for newly diagnosed ALL. Ten of the cases were identified by RT-PCR only. In none of the 21 patients with T-cell immunophenotypes could an expression of the BCR- ABL mRNA be detected. BCR-ABL positivity was associated with a significantly shorter duration of first remission (P = .0086) and higher white blood cell (P = .0157) and blast cell counts (P = .0304) at relapse diagnosis. All patients were treated according to the ALL- REZ BFM 87 and 90 relapse trials of the BFM Relapse Study Group. The intensive multiagent chemotherapy induced a second complete remission in only 60% of children with BCR-ABL-positive ALL compared with in 91% of those without BCR-ABL expression (P = .0023). The prognosis of BCR- ABL-positive ALL in children is poor, with a probability of event-free survival at 2 years of 8% versus 50% in those without BCR-ABL mRNA or cytogenetic analysis should become part of the routine diagnostic panel for children with newly diagnosed ALL and is fundamental for children presenting with an early bone marrow relapse.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 2
    Electronic Resource
    Electronic Resource
    Oligonucleotide fingerprinting of tomato DNA (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 114 (1995), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Hinfl -digested DNA samples of wild and cultivated species of tomato were hybridized in gel to different oligonucleotide probes complementary to simple-sequence repeats. All motifs tested i.e. (GATA)4, (GGAT)4, (CA)8. (CAG)5, (GTG)5, (GAAGTGGG)2 and (CCTA)4, produced multilocus fingerprints in all tomato species and cultivars. The extent of inter- and intraspecific polymorphism of the banding patterns varied considerably between different probes, with (GGAT)4, (CCTA)4, (GATA)4 and (CA)8 showing a much higher discriminatory potential than the other probes. Cluster analysis of band-sharing data yielded dendrograms which were consistent with the known history of tomato cultivation. (GATA)4 was also successfully used for purity testing of breeding lines, as well as for analysing an F1 progeny of a cross between two lines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0523.1995.tb00751.x
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  • 3
    Electronic Resource
    Electronic Resource
    Fingerprinting plant genomes with oligonucleotide probes specific for simple repetitive DNA sequences (1992)
    Springer
    Theoretical and applied genetics 83 (1992), S. 691-694 
    Details
    ISSN: 1432-2242
    Keywords: DNA fingerprinting ; Repetitive DNA ; Genotype identification ; Angiosperms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Oligonucleotides hybridizing to simple repetitive DNA patterns are highly informative as probes for DNA fingerprinting in all investigated animal species, including man. Here we demonstrate the applicability of this technique in higher plants. The oligonucleotide probes (GTG)5 and (GATA)4 were used to investigate the differences in DNA fingerprint patterns of the following angiosperm species: Triticum aestivum, Secale cereale, Hordeum vulgare, Beta vulgaris, Petunia hybrida, Brassica oleracea, and Nicotiana tabacum. Two species, Hordeum vulgare as a monocot and Beta vulgaris as a dicot, were analyzed in more detail. Their genomes differ considerably in both amount and organization of the simple repetitive sequences (GATA)n, (GACA)n, (GTG)n, and (CT)n due to the evolutionary distance of these two species. Furthermore, several lines and cultivars of Beta vulgaris and Hordeum vulgare can clearly be distinguished on the basis of their highly polymorphic patterns of these repetitive sequences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226686
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