ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Bisphosphonates (BP) are drugs currently administered orally to treat diseasescharacterised by an excessive bone resorption. Alternative and more efficient delivery routes andmore potent compounds are being investigated. Three implantable delivery systems, which allowthe controlled release of therapeutic agents from the device core, are examined in this paper. (4-(aminomethyl) benzene) bisphosphonic acid (ABBP) was incorporated onCa8.8Na0.8(PO4)4.8(CO3)1.2(OH)0.4F1.6 particles by refluxing the powder in a 60 mmol suspension inacetone at 60ºC for 5 hours. 4-aminophenyl acetic bisphosphonate monosodium salt (APBP) and 1-H-indole-3-acetic bisphosphonate monosodium (IBP) were loaded on Ca10(PO4)6(OH)1F1 ceramicbodies by stirring the ceramic bodies in 0.04M BP solutions. Injectable acrylic cements based onself-curing formulations of methyl methacrylate (MMA) and vitamin E were loaded with APBP andIBP. The incorporation of ABBP was confirmed by MAS-NMR spectroscopy. Modified powdershows two different phosphorous environments, the first one at 2.91 ppm can be assigned to theapatite base and the second one at 18.0 ppm has to be attributed to the phosphonic group of theABBP. The IBP addition on ceramic surfaces did not decrease the number of osteoclast coloniesand appeared to improve the performance of the HA as a surface for osteoblast culture. Atherapeutic dosage of APBP and IBP can be achieved from acrylic cements that showed lack oftoxicity and an increased cellular activity and proliferation
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1041.pdf
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