Publication Date:
2010-09-17
Description:
The ability to produce vigorous immune responses that spare self tissues and organs depends on the elimination of autoreactive T and B cells. However, purging of immature and mature self-reactive T and B cells is incomplete and may also require the involvement of cells programmed to suppress immune responses. Regulatory T cells (T(reg)) belonging to the CD4(+) T-cell subset may have a role in preventing untoward inflammatory responses, but T-cell subsets programmed to inhibit the development of autoantibody formation and systemic-lupus-erythematosus-like disease have not yet been defined. Here we delineate a CD8(+) regulatory T-cell lineage that is essential for the maintenance of self tolerance and prevention of murine autoimmune disease. Genetic disruption of the inhibitory interaction between these CD8(+) T cells and their target Qa-1(+) follicular T-helper cells results in the development of a lethal systemic-lupus-erythematosus-like autoimmune disease. These findings define a sublineage of CD8 T cells programmed to suppress rather than activate immunity that represents an essential regulatory element of the immune response and a guarantor of self tolerance.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395240/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395240/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Hye-Jung -- Verbinnen, Bert -- Tang, Xiaolei -- Lu, Linrong -- Cantor, Harvey -- AI 037562/AI/NIAID NIH HHS/ -- R01 AI037562/AI/NIAID NIH HHS/ -- T32 CA009382/CA/NCI NIH HHS/ -- T32 CA070083/CA/NCI NIH HHS/ -- England -- Nature. 2010 Sep 16;467(7313):328-32. doi: 10.1038/nature09370.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20844537" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies/immunology
;
Antibody Affinity/immunology
;
Antigens/immunology
;
Antigens, CD44/immunology/metabolism
;
Autoantibodies/biosynthesis/immunology
;
CD8-Positive T-Lymphocytes/*cytology/*immunology
;
Cell Lineage
;
Germinal Center/cytology/immunology
;
Histocompatibility Antigens Class I/genetics/immunology/metabolism
;
Immunoglobulin G/blood
;
Lupus Erythematosus, Systemic/immunology
;
Mice
;
Models, Immunological
;
Mutation
;
Self Tolerance/*immunology
;
T-Lymphocytes, Helper-Inducer/*cytology/*immunology/metabolism
;
T-Lymphocytes, Regulatory/cytology/immunology
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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