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  • 1
    Electronic Resource
    Electronic Resource
    K slicing the Schwarzschild and the Reissner–Nordstrom spacetimes (1999)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 40 (1999), S. 5883-5889 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: A K slicing of the Reissner–Nordstrom (RN) spacetime is shown to provide a complete foliation of the region up to the inner horizon, and the horizon to correspond to the limit as K→±∞. The implications of this foliation in the context of York time are discussed. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.533060
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  • 2
    Electronic Resource
    Electronic Resource
    Biochemistry and molecular genetics of cell-wall lipid biosynthesis in mycobacteria (1997)
    Oxford BSL : Blackwell Science Ltd
    Molecular microbiology 24 (1997), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Tuberculosis and other mycobacterial infections are the most serious infectious diseases in terms of human fatalities. The high content of unique cell-wall lipids helps these organisms to resist antimicrobial drugs and host defences. The biosynthesis of these lipids is discussed briefly. The recent advances in recombinant DNA technology have begun to help to elucidate the nature of some of the enzymes involved in this process and the genes that encode them. Gene disruption and other molecular genetic technologies are beginning to provide new approaches to test for the biological functions of these gene products and may lead to identification of new antimycobacterial drug targets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2958.1997.3361705.x
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  • 3
    Electronic Resource
    Electronic Resource
    Epidemiology of Murine Typhus (1990)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 35 (1990), S. 553-570 
    Details
    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.en.35.010190.003005
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  • 4
    Electronic Resource
    Electronic Resource
    FRACTURE ENERGY OF WEAKLY REINFORCED CONCRETE BEAMS (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 12 (1989), S. 0 
    Details
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract— An experimental investigation was conducted on a series of simply supported concrete beams with an aim to determine the fracture energy of the composite beam and apply the concept of fracture mechanics to predict flexural strength. In order that a single crack from the tip of the premolded central notch would propagate, the beams were lightly reinforced with a large cover so that the moment capacity of the beam as unreinforced section would be greater than that of the reinforced section. Based on test data, compliance calibration and energy release rate (G1) curves are presented for progressive cracking and a correlation between the critical energy release rate and ultimate moment capacity is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-2695.1989.tb00504.x
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  • 5
    Electronic Resource
    Electronic Resource
    Extracellular addition of a domain of HIV-1 Vpr containing the amino acid sequence motif H(S/F)RIG causes cell membrane permeabilization and death (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 19 (1996), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Vpr is a virion-associated protein of human immuno-deficiency virus type 1 (HIV-1) whose function in acquired immune deficiency syndrome (AIDS) has been uncertain. We previously employed yeast as a model to examine the effects of Vpr on basic cellular functions; intracellular Vpr was shown to cause cell-growth arrest and structural defects, and these effects were caused by a region of Vpr containing the sequence HFRIGCRHSRIG. Here we show that peptides containing the H(S/F)RIG amino acid sequence motif cause death when added externally to a variety of yeast including Saccharomyces cerevisiae, Kluyveromyces lactis, Candida glabrata, Candida albicans and Schizosaccharomyces pombe. Such peptides rapldly entered the cell from the time of addition, resulting in cell death. Elevated levels of ions, particularly magnesium and calcium ions, abrogated the cytotoxic effect by preventing the Vpr peptides from entering the cells. Extracellular Vpr found in the serum, or breakdown products of extracellular Vpr, may have similar effects to the Vpr peptides described here and could explain the death of uninfected by-stander cells during AIDS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1996.tb02464.x
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  • 6
    Electronic Resource
    Electronic Resource
    Thermodynamic stability of Y2BaO4 by CaF2-based e.m.f. measurements (1989)
    Springer
    Journal of materials science 8 (1989), S. 67-68 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00720254
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  • 7
    Electronic Resource
    Electronic Resource
    Thermodynamic stability of Y2Ba4O7 by CaF2-based e.m.f. measurements (1990)
    Springer
    Journal of materials science 9 (1990), S. 304-307 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00725832
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  • 8
    Electronic Resource
    Electronic Resource
    A C-terminal domain of HIV-1 accessory protein Vpr is involved in penetration, mitochondrial dysfunction and apoptosis of human CD4+ lymphocytes (1997)
    Springer
    Apoptosis 2 (1997), S. 69-76 
    Details
    ISSN: 1573-675X
    Keywords: Apoptosis ; CD4+ lymphocytes ; cell penetration ; HIV-1 ; mitochondrial dysfunction ; Vpr
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have previously shown that expression of HIV-1 vpr in yeast results in cell growth arrest and structural defects, and identified a C-terminal domain of Vpr as being responsible for these effects in yeast.1 In this report we show that recombinant Vpr and C-terminal peptides of Vpr containing the conserved sequence HFRIGCRHSRIG caused permeabilization of CD4+ T lymphocytes, a dramatic reduction of mitochondrial membrane potential and finally cell death. Vpr and Vpr peptides containing the conserved sequence rapidly penetrated cells, co-localized with the DNA, and caused increased granularity and formation of dense apoptotic bodies. The above results suggest that Vpr treated cells undergo apoptosis and this was confirmed by demonstration of DNA fragmentation by the highly sensitive TUNEL assay. Our results, together with the demonstration of extracellular Vpr in HIV infected individuals,2,3 suggest the possibility that extracellular Vpr could contribute to the apoptotic death and depletion of bystander cells in lymphoid tissues4,5 during HIV infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026487609215
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  • 9
    Electronic Resource
    Electronic Resource
    Combined experimental-numerical approach to characterization of steel-glue-concrete interface (1995)
    Springer
    Materials and structures 28 (1995), S. 518-525 
    Details
    ISSN: 1359-5997
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Description / Table of Contents: Resume Cet article présente une approche à la fois expérimentale et numérique pour ordoner les nombreux résultats, parfois contradictories, reflétant la caractérisation de l'interface béton/acier collé à l'époxy. Sur la base des données fournies par une éprouvette spécialement conçue en 1/2 poutre et des résultats expérimentaux apportés par d'autres géométries d'éprouvettes, combinés avec leur idéalisation respective par la méthode non-linéaire des éléments finis, on suggère, pour l'interface acier—adhésif—béton, une loi de rupture Mohr—Coulomb modifiée. On peut alors utiliser la simulation de ce comportement (éléments finis) d'une poutre en béton renforcé d'une plaque.
    Notes: Abstract An experimental—numerical approach is presented to rationalize the plethora of results, sometimes contradictory, reflecting the chrracterization of an epoxy bonded steel—concrete interface. Based on data from a specially designed half-beam specimen and experimental results from other specimen geometries, combined with their respective nonlinear finite element idealizations, a classical Mohr—Coulomb failure law together with a tension cut-off are suggested for the steel—glue—concrete interface. This description can then be used in a finite element simulation of a plated reinforced concrete beam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02473156
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  • 10
    Electronic Resource
    Electronic Resource
    Expression of HIV-1nefin yeast causes membrane perturbation and release of the myristylated Nef protein (1998)
    Springer
    Journal of biomedical science 5 (1998), S. 203-210 
    Details
    ISSN: 1423-0127
    Keywords: Acquired immunodeficiency syndrome ; Human immunodeficiency virus ; Nef protein ; Myristylation ; Membrane permeabilisation ; Saccharomyces cerevisiae ; Yeast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The human immunodeficiency virus type 1 (HIV-1) Nef protein is essential for AIDS pathogenesis, but its function remains highly controversial. During stresses such as growth in the presence of copper or at elevated temperature, myristylated Nef is released from yeast cells and, after extended culture in stationary phase, it accumulates in the supernatant as a dense membranous material that can be centrifuged into a discrete layer above the cell pellet. This material is unique to Nef-producing cells and represents a convenient source of Nef that may have application in further biological studies. Within the yeast cell, electron microscopic examination shows that Nef localises in novel, membrane-bound bodies. These data support the evidence for a role of Nef in membrane perturbation and suggest that there may be a similar localisation for myristylated Nef in HIV-1 infected cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02253470
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