Publication Date:
1999-07-10
Description:
Microarray-based gene expression analysis identified genes showing ploidy-dependent expression in isogenic Saccharomyces cerevisiae strains that varied in ploidy from haploid to tetraploid. These genes were induced or repressed in proportion to the number of chromosome sets, regardless of the mating type. Ploidy-dependent repression of some G1 cyclins can explain the greater cell size associated with higher ploidies, and suggests ploidy-dependent modifications of cell cycle progression. Moreover, ploidy regulation of the FLO11 gene had direct consequences for yeast development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Galitski, T -- Saldanha, A J -- Styles, C A -- Lander, E S -- Fink, G R -- GM35010/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1999 Jul 9;285(5425):251-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10398601" target="_blank"〉PubMed〈/a〉
Keywords:
Chitinase/genetics
;
Cyclins/genetics
;
Fungal Proteins/genetics
;
G1 Phase
;
*Gene Expression Regulation, Fungal
;
Haploidy
;
Lipoproteins/genetics/physiology
;
Membrane Glycoproteins
;
Membrane Proteins/genetics
;
Oligonucleotide Array Sequence Analysis
;
Peptides/genetics/physiology
;
Pheromones
;
*Ploidies
;
Polyploidy
;
Saccharomyces cerevisiae/cytology/*genetics/physiology
;
*Saccharomyces cerevisiae Proteins
;
Transcription Factors/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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