Publication Date:
2014-09-13
Description:
The African continent continues to bear the greatest burden of malaria and the greatest diversity of parasites, mosquito vectors, and human victims. The evolutionary plasticity of malaria parasites and their vectors is a major obstacle to eliminating the disease. Of current concern is the recently reported emergence of resistance to the front-line drug, artemisinin, in South-East Asia in Plasmodium falciparum, which calls for preemptive surveillance of the African parasite population for genetic markers of emerging drug resistance. Here we describe the Plasmodium Diversity Network Africa (PDNA), which has been established across 11 countries in sub-Saharan Africa to ensure that African scientists are enabled to work together and to play a key role in the global effort for tracking and responding to this public health threat.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541720/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541720/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ghansah, Anita -- Amenga-Etego, Lucas -- Amambua-Ngwa, Alfred -- Andagalu, Ben -- Apinjoh, Tobias -- Bouyou-Akotet, Marielle -- Cornelius, Victoria -- Golassa, Lemu -- Andrianaranjaka, Voahangy Hanitriniaina -- Ishengoma, Deus -- Johnson, Kimberly -- Kamau, Edwin -- Maiga-Ascofare, Oumou -- Mumba, Dieudonne -- Tindana, Paulina -- Tshefu-Kitoto, Antoinette -- Randrianarivelojosia, Milijaona -- William, Yavo -- Kwiatkowski, Dominic P -- Djimde, Abdoulaye A -- 090532/Wellcome Trust/United Kingdom -- 090770/Wellcome Trust/United Kingdom -- G0600718/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2014 Sep 12;345(6202):1297-8. doi: 10.1126/science.1259423.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Noguchi Memorial Institute for Medical Research, Accra, Ghana. ; Navrongo Health Research Centre, Navrongo, Ghana. ; Medical Research Council, Gambia Unit, Banjul, The Gambia. ; KEMRI/United States Army Medical Research Unit-Kenya, Kisumu, Nairobi, Kenya. ; Department of Biochemistry and Molecular Biology, University of Buea, Buea, Cameroon. ; Department of Parasitology Mycology, Faculty of Medicine, Universite des Sciences de la Sante, Libreville, Gabon. ; MRC Centre for Genomics and Global Health, University of Oxford, Oxford, UK. ; Aklilu Lemma Institute of Pathobiology, Addis Ababa University and Armauer Hansen Research Institute, Addis Ababa, Ethiopia. ; Malaria Research Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar. ; National Institute for Medical Research, Tanga, Tanzania. ; Malaria Research and Training Centre (MRTC), Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali. Bernhard Nocht Institute for Tropical Medicine in Hamburg, Germany. ; Institut National de Recherche Biomedicale, Ecole de Sante Publique/Faculte de Medecine/Universite de Kinshasa, Kinshasa, Democratic Republic of the Congo. ; Malaria Research and Control Center, National Institute of Public Health, Abidjan, Ivory Coast. ; MRC Centre for Genomics and Global Health, University of Oxford, Oxford, UK. Wellcome Trust Sanger Institute, Hinxton, UK. ; Malaria Research and Training Centre (MRTC), Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali. Wellcome Trust Sanger Institute, Hinxton, UK. adjimde@icermali.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25214619" target="_blank"〉PubMed〈/a〉
Keywords:
Africa South of the Sahara/epidemiology
;
Animals
;
Anopheles gambiae/parasitology
;
Antimalarials/*pharmacology/therapeutic use
;
Artemisinins/*pharmacology/therapeutic use
;
*Disease Eradication
;
Drug Resistance/*genetics
;
*Epidemiological Monitoring
;
Genetic Variation
;
Humans
;
Malaria, Falciparum/drug therapy/parasitology/*prevention & control
;
Plasmodium falciparum/drug effects/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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