ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
The decrease in bone mass caused by wear debris-induced osteolysis could have beencompensated through osteoblasts secreting enough new bone matrix. However, the normalosteoblastic population depends on the regular differentiation of their progenitor cells, the bonemarrow mesenchymal stem cells (BMSCs). It is not possible to predict whether wear particles willaffect the BMSCs’ viability, and subsequently their differentiation. Furthermore, little is known aboutthe extent to which the sizes of the wear particles loading can impact the viability the most. This studyhas, therefore, concentrated on the potential mechanism for rat BMSCs’ (rBMSCs) viabilityinfluenced by different-sized titanium particle (Ti) loading in vitro.rBMSCs were harvested andloaded with circular Ti particles having three different mean diameters, 0.9, 2.7 and 6.9 .mrespectively. The results showed that different-sized titanium particles all inhibited rBMSCs’proliferation and induced rBMSCs’ apoptosis response , but this influence varied with the size of theTi particles, their concentration and the duration of loading. The smallest Ti particles (0.9.m)exhibited the earliest and largest suppression on the proliferation and the most powerful induction onthe apoptotic response of rBMSCs. qRT-PCR analysis demonstrated that those apoptotic effects wereassociation with the abnormal accentuation of inducible nitric oxide synthase(iNOS) activity. Thesize of titanium particles generated through wear of a prosthetic device and the osteoblastic progenitorBMSCs may be both important considerations in the development of superior implant technology
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.1063.pdf
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