ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Rate constants for binding, dissociation, and internalization of EGF: effect of receptor occupancy and ligand concentration (1990)
    s.l. : American Chemical Society
    Biochemistry 29 (1990), S. 3563-3569 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00466a020
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    QUORUM SENSING: Cell-to-Cell Communication in Bacteria (2005)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Cell and Developmental Biology 21 (2005), S. 319-346 
    Details
    ISSN: 1081-0706
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Bacteria communicate with one another using chemical signal molecules. As in higher organisms, the information supplied by these molecules is critical for synchronizing the activities of large groups of cells. In bacteria, chemical communication involves producing, releasing, detecting, and responding to small hormone-like molecules termed autoinducers . This process, termed quorum sensing, allows bacteria to monitor the environment for other bacteria and to alter behavior on a population-wide scale in response to changes in the number and/or species present in a community. Most quorum-sensing-controlled processes are unproductive when undertaken by an individual bacterium acting alone but become beneficial when carried out simultaneously by a large number of cells. Thus, quorum sensing confuses the distinction between prokaryotes and eukaryotes because it enables bacteria to act as multicellular organisms. This review focuses on the architectures of bacterial chemical communication networks; how chemical information is integrated, processed, and transduced to control gene expression; how intra- and interspecies cell-cell communication is accomplished; and the intriguing possibility of prokaryote-eukaryote cross-communication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.cellbio.21.012704.131001
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Transport of Platelets in Flowing Blood (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 516 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb33065.x
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    An amino-terminal domain of Enterococcus faecalis aggregation substance is required for aggregation, bacterial internalization by epithelial cells and binding to lipoteichoic acid (2004)
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 52 (2004), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Aggregation substance (AS), a plasmid-encoded surface protein of Enterococcus faecalis, plays important roles in virulence and antibiotic resistance transfer. Previous studies have suggested that AS-mediated aggregation of enterococcal cells could involve the binding of this protein to cell wall lipoteichoic acid (LTA). Here, a method to purify an undegraded form of Asc10, the AS of the plasmid pCF10, is described. Using this purified protein, direct binding of Asc10 to purified E. faecalis LTA was demonstrated. Equivalent binding of Asc10 to LTA purified from INY3000, an E. faecalis strain that is incapable of aggregation, was also observed. Surprisingly, mutations in a previously identified aggregation domain from amino acids 473 to 683 that abolished aggregation had no effect on LTA binding. In frame deletion analysis of Asc10 was used to identify a second aggregation domain located in the N-terminus of the protein from amino acids 156 to 358. A purified Asc10 mutant protein lacking this domain showed reduced LTA binding, while a purified N-terminal fragment from amino acids 44–331 had high LTA binding. Like the previously described aggregation domain, the newly identified Asc10(156−358) aggregation domain was also required for efficient internalization of E. faecalis into HT-29 enterocytes. Thus, Asc10 possess two distinct domains required for aggregation and eukaryotic cell internalization: an N-terminal domain that promotes binding to LTA and a second domain located near the middle of the protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.2004.04045.x
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    The detachment strength and morphology of bone cells contacting materials modified with a peptide sequence found within bone sialoprotein (1997)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 37 (1997), S. 9-19 
    Details
    ISSN: 0021-9304
    Keywords: cell adhesion ; tissue engineering ; peptide immobilization ; bone cells ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Adhesion, spreading, and focal contact formation of primary bone-derived cells on quartz surfaces grafted with a 15 amino acid peptide that contained a -RGD-(-Arg-Gly-Asp-) sequence unique to bone sialoprotein was investigated. The peptide surfaces were fabricated by using a heterbifunctional crosslinker, sulfosuccinimidyal 4-(N-maleimidomethyl)cyclohexane-1-carboxylate, to link the peptide to amine functionalized quartz surfaces. Contact angle measurements, spectroscopic ellipsometry, and X-ray photoelectron spectroscopy were used to confirm the chemistry and thickness of the overlayers. A radial flow apparatus was used to characterize cell detachment from peptide-grafted surfaces. After 20 min of cell incubation, the strength of cell adhesion was significantly (p 〈 0.05) higher on the -RGD- compared to -RGE- (control) surfaces. Furthermore, the mean area of cells contacting the -RGD- was significantly (p 〈 0.05) higher than -RGE- surfaces. Vinculin staining showed formation of small focal contact patches on the periphery of bone cells incubated for 2 h on the -RGD- surfaces; however, few or no focal contacts were formed by cells seeded on the -RGE- grafted surfaces. The methods of peptide immobilization utilized in this study can be applied to implants, biosensors, and diagnostic devices that require specificity in cell adhesion. © 1997 John Wiley & Sons, Inc. J Biomed Mater Res, 37, 9-19, 1997.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
  • 6
    Electronic Resource
    Electronic Resource
    Analysis of the influences of the E5 transforming protein on kinetic parameters of epidermal growth factor binding and metabolism (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 152 (1992), S. 253-263 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The E5 protein of the bovine papillomavirus induces cellular transformation when transfected into NIH 3T3 cells, and the extent of focal transformation is enhanced by cotransfection with the epidermal growth factor (EGF) receptor (Martin et al., Cell 59:21-32, 1989). To determine whether E5 affects EGF:receptor interactions, we analyzed the kinetics of 125I-EGF processing using a mathematical model that enabled us to evaluate rate constants for ligand association (ka), dissociation (kd), internalization (ke), recycling (kr), and degradation (kh). These rate constants were measured in NIH 3T3 cells transfected with the human EGF receptor (ER cells) and in cells transfected with both the EGF receptor and E5 (E5/ER cells). We found that the rate constant for 125I-EGF association ka was significantly decreased in E5/ER cells, but was apparently occupancy-independent in both cell lines. The 125I-EGF dissociation rate constant kd was significantly lower in E5 transformed cells, and increased with occupancy in both cell lines. This suggests that E5 alters the receptor before or during EGF binding so that ligand association is slower; however, once complexes are formed, EGF is bound more tightly to the receptor. Rate constants for internalization ke were also found to be occupancy-dependent, although at a given level of occupancy ke was similar for both cell lines. Also, there was no apparent effect of E5 on the recycling rate constant kr. The 125I-EGF degradation rate constant kh was 30% lower in E5 transformed cells, and was occupancy-independent. The overall effect of E5 is to stabilize intact EGF:receptor complexes which may alter mitogenic signaling of the receptor. © 1992 Wiley-Liss, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041520206
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Endocytosis of growth factor receptors (1993)
    New York, NY : Wiley-Blackwell
    BioEssays 15 (1993), S. 375-382 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Binding of a growth factor (GF) to its specific receptor on the cell surface causes the initiation of a signal transduction cascade which eventually results in mitosis. GF:receptor complexes are removed from the cell surface via receptor-mediated endocytosis, a process which involves clathrin-coated pits. After internalization into the endosomal compartment, a significant pool of GFs and GF receptors escape recycling to the cell surface and are sorted to the degradation pathway. The ligandinduced internalization and lysosomal degradation of GF receptors result in the dramatic loss of surface receptors, a phenomenon termed receptor down-regulation. In this review, we discuss relevant biochemical, morphological and kinetic studies of the mechanism of GF endocytosis, and the possible role of this process in mitogenic signaling by growth factor receptors.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950150603
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    facet.materialart.
    Unknown
    Seafloor photo-geology and sonar terrain modeling at the 9°N overlapping spreading center, East Pacific Rise (2014)
    John Wiley & Sons
    Details
    Publication Date: 2022-05-25
    Description: © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Geochemistry, Geophysics, Geosystems 14 (2013): 5146–5170, doi:10.1002/2013GC004858.
    Description: A fundamental goal in the study of mid-ocean ridges is to understand the relationship between the distribution of melt at depth and seafloor features. Building on geophysical information on subsurface melt at the 9°N overlapping spreading center on the East Pacific Rise, we use terrain modeling (DSL-120A side scan and bathymetry), photo-geology (Jason II and WHOI TowCam), and geochemical data to explore this relationship. Terrain modeling identified four distinct geomorphic provinces with common seafloor characteristics that correspond well to changes in subsurface melt distribution. Visual observations were used to interpret terrain modeling results and to establish a relative seafloor age scale, calibrated with radiometric age dates, to identify areas of recent volcanism. On the east limb, recent eruptions in the north are localized over the margins of the 4 km wide asymmetric melt sill, forming a prominent off-axis pillow ridge. Along the southern east limb, recent eruptions occur along a neovolcanic ridge that hugs the overlap basin and lies several kilometers west of the plunging melt sill. Our results suggest that long-term southward migration of the east limb occurs through a series of diking events with a net southward propagation direction. Examining sites of recent eruptions in the context of geophysical data on melt distribution in the crust and upper mantle suggests melt may follow complex paths from depth to the surface. Overall, our findings emphasize the value of integrating information obtained from photo-geology, terrain modeling, lava geochemistry and petrography, and geophysics to constrain the nature of melt delivery at mid-ocean ridges.
    Description: The National Science Foundation and the RIDGE2000 program supported this work through grants OCE0526120 to E.M.K., OCE0525872 to S.M.W., OCE0527075 to M.R.P., and OCE 052705300 to K.W.W.S.
    Keywords: Mid-ocean ridge ; Overlapping spreading center ; Melt lens ; Axial magma chamber ; Dike ; Ocean crust
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 9
    facet.materialart.
    Unknown
    Temporal and petrogenetic constraints on volcanic accretionary processes at 9-10 degrees north East Pacific Rise (2010)
    Massachusetts Institute of Technology and Woods Hole Oceanographic Institution
    Details
    Publication Date: 2022-05-25
    Description: Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at the Massachusetts Institute of Technology and the Woods Hole Oceanographic Institution June 2010
    Description: Volcanic accretion at the fast-spreading East Pacific Rise (EPR) occurs over a ~2-4 km wide neo-volcanic zone on either side of the axial summit trough (AST). Eruption ages are critical for understanding the distribution and timing of volcanic and magmatic activity. Uranium series nuclides are susceptible to fractionation by magmatic processes that occur beneath mid-ocean ridges, and the half-lives of 226Ra (1.6 kyrs) and 230Th (75 kyrs) make them ideally suited for determining eruption ages and placing constraints on eruption frequency and temporal changes in magma chemistry. Accordingly, major and trace element, and long-lived radiogenic and 238U-230Th-226Ra isotope compositions were measured in basalts from 9º-10ºN EPR to determine eruption ages and to place temporal constraints on volcanic and magmatic processes. At 9º30’N EPR, 238U-230Th-226Ra compositions indicate that trace elementally and isotopically enriched mid-ocean ridge basalt (MORB) collected off-axis erupted 〉8 ka and that E-MORB magmatism is interspersed with normal, depleted MORB magmatism. Lava ages are consistent with eruption from the AST and flow down the ridge flanks, which is in contrast to previous studies that suggested E-MORB erupted from off-axis vents. At 9º50’N EPR, discrete eruptive units are distinguished by high precision 238U, 232Th, and 226Ra sample concentrations, but because the resolution of the 230Th-226Ra model age dating technique is ~±1 kyrs, the surprisingly young ages of these lavas prohibit the construction of an explicit, time-constrained lava stratigraphy. Nonetheless, seven different flows identified within 0.8-2.0 km west of the AST imply greater frequency of flows to these distances than previously recognized. Model age dating of ferrobasalts, basaltic andesites, andesites, and dacites sampled from the east limb of the overlapping spreading center at 9º03’N EPR is difficult due to uncertainties in magma residence times. However, (226Ra/230Th) disequilibria indicate recent basaltic volcanism (〈〈8 ka) up to ~4 km off-axis. The axial graben at the rise crest sources the most recent volcanic activity and is the dominant location for eruption of high-silica magmas. Major element, trace element, 87Sr/86Sr, and (234U/238U) isotope compositions are consistent with the formation of dacite magmas by extensive crystallization, and 238U-230Th-226Ra systematics imply crustal residence times of ~8 kyrs.
    Description: This research was made possible by funding from the Academic Programs Office, from the WHOI travel assistance funds, a Goldschmidt student travel grant, and National Science Foundation grants OCE-0623838, OCE-0527053, and OCE-0137325 to K.W.W.S.
    Keywords: Volcanism ; Submarine geology ; Atlantis (Ship : 1996-) Cruise AT15-7 ; Atlantis (Ship : 1996-) Cruise AT11-7 ; Atlantis (Ship : 1996-) Cruise AT15-17
    Repository Name: Woods Hole Open Access Server
    Type: Thesis
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 10
    facet.materialart.
    Unknown
    Recent volcanic accretion at 9°N–10°N East Pacific Rise as resolved by combined geochemical and geological observations (2013)
    John Wiley & Sons
    Details
    Publication Date: 2022-05-25
    Description: Author Posting. © American Geophysical Union, 2013. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry, Geophysics, Geosystems 14 (2013): 2547–2574, doi:10.1002/ggge.20134.
    Description: The ridge crest at 9°N–10°N East Pacific Rise (EPR) is dominated by overlapping lava flows that have overflowed the axial summit trough and flowed off-axis, forming a shingle-patterned terrain up to ∼2–4 km on either side of the axial summit trough. In this study, we employ 230Th-226Ra dating methods, in conjunction with geochemistry and seafloor geological observations, in an effort to discern the stratigraphic relationships between adjacent flows. We measured major and trace elements and 87Sr/86Sr, 143Nd/144Nd, 176Hf/177Hf, and 238U-230Th-226Ra for lava glass samples collected from several flow units up to ∼2 km away from the axial summit trough on the ridge crest at 9°50′N EPR. Statistical analysis of the 238U-230Th-226Ra data indicates that all but one measured sample from these flows cannot be resolved from the zero-age population; thus, we cannot confidently assign model ages to samples for discerning stratigraphic relationships among flows. However, because groups of samples can be distinguished based on similarities in geochemical compositions, particularly incompatible element abundances with high precision-normalized variability such as U and Th, and because the range of compositions is much greater than that represented by samples from the 1991–1992 and 2005–2006 eruptions, we suggest that the dive samples represent 6–10 eruptive units despite indistinguishable model ages. Geochemical variability between individual flows with similar ages requires relatively rapid changes in parental melt composition over the past ∼2 ka, and this likely reflects variations in the relative mixing proportions of depleted and enriched melts derived from a heterogeneous mantle source.
    Description: This study was funded by NSF OCE-0623838 to K.W.W. Sims and S.A. Soule and NSF OCE-0527053 to K.W.W. Sims. J. Blichert-Toft acknowledges financial support from the French Agence Nationale de la Recherche (grant M&Ms – Mantle Melting – Measurements, Models, Mechanisms).
    Description: 2014-02-01
    Keywords: U-series ; Geochemistry ; Geochronology ; East Pacific Rise
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
    Format: application/msword
    Format: application/vnd.ms-excel
    Format: application/postscript
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...