ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Decoupling of spurious deeply bound states with the similarity renormalization group (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-03-18
    Description: Author(s): K. A. Wendt, R. J. Furnstahl, and R. J. Perry The similarity renormalization group (SRG) is a continuous series of unitary transformations that can be implemented as a flow equation. When the relative kinetic energy (T_{rel} ) is used in the SRG generator, nuclear structure calculations have shown greatly improved convergence with basis size be... [Phys. Rev. C 83, 034005] Published Thu Mar 17, 2011
    Keywords: Nucleon-Nucleon Interaction, Few-Body Systems
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Universality in similarity renormalization group evolved potential matrix elements and T-matrix equivalence (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-01-23
    Description: Author(s): B. Dainton, R. J. Furnstahl, and R. J. Perry We examine how the universality of two-nucleon interactions evolved using similarity renormalization group (SRG) transformations correlates with T-matrix equivalence, with the ultimate goal of gaining insight into universality for three-nucleon forces. With sufficient running of the SRG flow equatio... [Phys. Rev. C 89, 014001] Published Wed Jan 22, 2014
    Keywords: Nucleon-Nucleon Interaction, Few-Body Systems
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-06-06
    Description: Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and mortality rates, and soaring health-care costs. Developing interventions requires a comprehensive understanding of the mechanisms by which excess hepatic lipid develops and causes hepatic insulin resistance and type 2 diabetes. Proposed mechanisms implicate various lipid species, inflammatory signalling and other cellular modifications. Studies in mice and humans have elucidated a key role for hepatic diacylglycerol activation of protein kinase Cepsilon in triggering hepatic insulin resistance. Therapeutic approaches based on this mechanism could alleviate the related epidemics of non-alcoholic fatty liver disease and type 2 diabetes.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489847/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489847/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, Rachel J -- Samuel, Varman T -- Petersen, Kitt F -- Shulman, Gerald I -- I01 BX000901/BX/BLRD VA/ -- P30 DK-45735/DK/NIDDK NIH HHS/ -- P30 DK034989/DK/NIDDK NIH HHS/ -- R01 AG-23686/AG/NIA NIH HHS/ -- R01 DK-40936/DK/NIDDK NIH HHS/ -- R01 DK-49230/DK/NIDDK NIH HHS/ -- R01 DK040936/DK/NIDDK NIH HHS/ -- R24 DK-085836/DK/NIDDK NIH HHS/ -- T32-DK101019/DK/NIDDK NIH HHS/ -- U24 DK-059635/DK/NIDDK NIH HHS/ -- UL1 RR-024139/RR/NCRR NIH HHS/ -- England -- Nature. 2014 Jun 5;510(7503):84-91. doi: 10.1038/nature13478.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA. ; 1] Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA. [2] VA Connecticut Healthcare System West Haven, Connecticut 06516, USA. ; 1] Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA. [2] Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen DK-2200, Denmark. ; 1] Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA. [2] Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen DK-2200, Denmark. [3] Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. [4] Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06535-8012, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24899308" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diabetes Mellitus, Type 2/drug therapy/*metabolism ; Diglycerides/metabolism ; Fatty Liver/drug therapy/metabolism ; Humans ; Hyperglycemia/metabolism ; *Insulin Resistance ; *Lipid Metabolism ; *Lipids/biosynthesis ; Lipodystrophy/metabolism ; Lipogenesis ; Liver/*metabolism ; Muscle, Skeletal/metabolism ; Non-alcoholic Fatty Liver Disease ; Triglycerides/biosynthesis
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-02-28
    Description: Nonalcoholic fatty liver disease (NAFLD) is a major factor in the pathogenesis of type 2 diabetes (T2D) and nonalcoholic steatohepatitis (NASH). The mitochondrial protonophore 2,4 dinitrophenol (DNP) has beneficial effects on NAFLD, insulin resistance, and obesity in preclinical models but is too toxic for clinical use. We developed a controlled-release oral formulation of DNP, called CRMP (controlled-release mitochondrial protonophore), that produces mild hepatic mitochondrial uncoupling. In rat models, CRMP reduced hypertriglyceridemia, insulin resistance, hepatic steatosis, and diabetes. It also normalized plasma transaminase concentrations, ameliorated liver fibrosis, and improved hepatic protein synthetic function in a methionine/choline-deficient rat model of NASH. Chronic treatment with CRMP was not associated with any systemic toxicity. These data offer proof of concept that mild hepatic mitochondrial uncoupling may be a safe and effective therapy for the related epidemics of metabolic syndrome, T2D, and NASH.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495920/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495920/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, Rachel J -- Zhang, Dongyan -- Zhang, Xian-Man -- Boyer, James L -- Shulman, Gerald I -- P30 DK-34989/DK/NIDDK NIH HHS/ -- P30 DK-45735/DK/NIDDK NIH HHS/ -- P30 DK034989/DK/NIDDK NIH HHS/ -- P30 DK045735/DK/NIDDK NIH HHS/ -- R01 DK-40936/DK/NIDDK NIH HHS/ -- R01 DK040936/DK/NIDDK NIH HHS/ -- R24 DK-085638/DK/NIDDK NIH HHS/ -- T32 DK-101019/DK/NIDDK NIH HHS/ -- U24 DK-059635/DK/NIDDK NIH HHS/ -- UL1 TR-000142/TR/NCATS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2015 Mar 13;347(6227):1253-6. doi: 10.1126/science.aaa0672. Epub 2015 Feb 26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA. ; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. ; Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. ; Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. Yale Liver Center, Yale University School of Medicine, New Haven, CT, USA. ; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA. gerald.shulman@yale.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25721504" target="_blank"〉PubMed〈/a〉
    Keywords: 2,4-Dinitrophenol/*administration & dosage/toxicity ; Animals ; Blood Glucose/metabolism ; Delayed-Action Preparations/*administration & dosage ; Diabetes Mellitus, Type 2/*drug therapy/metabolism ; Glucose Tolerance Test ; Insulin Resistance ; Lipid Metabolism ; Liver Cirrhosis/drug therapy ; Male ; Mice ; Mitochondria, Liver/drug effects/metabolism ; Muscle, Skeletal/metabolism ; Non-alcoholic Fatty Liver Disease/*drug therapy/metabolism ; Oxidation-Reduction ; Proton Ionophores/*administration & dosage/toxicity ; Random Allocation ; Rats ; Rats, Zucker
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    Electronic Resource
    Electronic Resource
    Extrusion of calcium from rod outer segments is driven by both sodium and potassium gradients (1989)
    [s.l.] : Nature Publishing Group
    Nature 337 (1989), S. 740-743 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The activity of the electrogenic exchange was measured from the membrane current produced by its operation in an isolated rod outer segment under whole-cell voltage clamp7. Two advantages of this preparation are that the exchange is the only significant carrier of membrane current when ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/337740a0
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    N-methylation of wholly aromatic polyamides for size-exclusion chromatography (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 45 (1992), S. 1983-1994 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Wholly aromatic polyamides, including poly(1,4-phenyleneisophthalamide) and poly(1,4-phenyleneterephthalamide) are N-methylated to render them soluble in N,N-dimethylformamide, a common size-exclusion chromatography eluent. The procedure N-methylates 50-55% of the total amide linkages in these two examples, permitting reproducible measurement of their absolute molecular weight distributions using differential viscometry detection. There is no observable degradation in molecular weight resulting from the N-methylation, provided the excess methylating reagent is destroyed shortly after completion of the derivatization by quenching with potassium acetate. The validity of the molecular weight data obtained by the method is confirmed by light-scattering measurements on derivatized polymer and by comparison to the molecular weight of underivatized polymer that can be approximated from the intrinsic viscosity in concentrated sulfuric acid. The method is applicable to a variety of wholly aromatic polyamide structures. Examples are given.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1992.070451113
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Charge transport in poly(methylphenylsilane): The case for superimposed disorder and polaron effects (1994)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 32 (1994), S. 1677-1685 
    Details
    ISSN: 0887-6266
    Keywords: charge transport ; disorder-controlled hopping ; disordered molecular solids ; polaron hopping ; poly(methylphenylsilane) ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Careful analysis of the temperature dependence of the hole mobility in poly (methylphenylsilane) indicates that the functional dependence is between an Arrhenius law and a ln μ ∝ T-2 law as predicted by a model of disorder-controlled hopping. This is attributed to the superposition of disorder and polaron effects. A method is presented for separating the two contributions. The evolution of time-of-flight photocurrent transients with decreasing temperature is consistent with the disorder parameter derived from the temperature dependence of the mobility. © 1994 John Wiley & Sons, Inc.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/polb.1994.090320912
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    facet.materialart.
    Unknown
    Operator evolution via the similarity renormalization group: The deuteron (2010)
    American Physical Society
    Details
    Publication Date: 2010-11-03
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo (2013)
    National Academy of Sciences
    Details
    Publication Date: 2013-07-09
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Molecular discrimination of shelf-spawned eggs of two co-occurring Trachurus spp. (Carangidae) in southeastern Australia: a key step to future egg-based biomass estimates (2015)
    Oxford University Press
    Details
    Publication Date: 2015-01-20
    Description: A molecular approach was successfully developed to discriminate between spawned eggs of the pelagic carangids Trachurus declivis and Trachurus novaezelandiae collected during ichthyoplankton surveys conducted in October 2002 and 2003 along shelf waters of Queensland (Qld) and New South Wales (NSW), in southeastern Australia (25 o 50'–37 o 30'S). Visually identified Trachurus eggs were subjected to mtDNA analysis by targeting specific fragments of the cytochrome oxidase subunit 1 ( CO1 ) and cytochrome b ( Cyt b ) genes, with three diagnostic sites (single-nucleotide polymorphisms) within a 297 bp segment of Cyt b (558, 588, 825) providing the best approach to discriminate between species. Polymerase chain reaction amplification and sequencing of 608 suspected Trachurus eggs resulted in 586 (96.4%) high-quality sequences that unequivocally identified 315 and 207 eggs as T. declivis and T. novaezelandiae , respectively, as well as 18 "variant haplotype" eggs that exhibited a base substitution at one of the diagnostic sites; the remaining 46 sequences aligned to three different genera in GenBank including two carangids, thus highlighting the effectiveness of molecular methods for egg identification. Rehydrated, mtDNA-verified eggs of T. declivis were significantly larger (0.97 ± 0.01 mm) than those of T. novaezelandiae (0.82 ± 0.01 mm), though still proved problematic to identify to species when relying on morphology alone. Egg distributions showed main spawning areas of T. declivis and T. novaezelandiae confined mostly to southern NSW (〉32°S) and northern NSW/southern Qld (〈32°S), respectively, with T. novaezelandiae likely to continue spawning further south during summer with the gradual temperature increase associated with the south-flowing East Australian Current. Overall findings support the adoption of comparable molecular protocols to verify identification of wild spawned eggs to species level, especially eggs collected during the application of the daily egg production method to estimate spawning biomass of pelagic species, as well as biological fish studies.
    Print ISSN: 1054-3139
    Electronic ISSN: 1095-9289
    Topics: Biology , Geosciences , Physics
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...