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  • 1
    Online Resource
    Online Resource
    Carotenoids: Biosynthetic and Biofunctional Approaches (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biochemistry. ; Plant biotechnology. ; Food science. ; Biotechnology. ; Nutrition   . ; Human physiology. ; Biochemistry. ; Plant Biotechnology. ; Food Science. ; Biotechnology. ; Nutrition. ; Human Physiology.
    Description / Table of Contents: Part I -- Commercial production of astaxanthin by Haematococcus, a green alga -- Commercial production of astaxanthin with Paracoccus carotinifaciens -- Production of carotenoids from cultivated seaweed -- Carotenoid metabolism in aquatic animals -- Carotenoid metabolism in terrestrial animals -- Metabolism of carotenoids in mammals -- Diversity and evolution of carotenoid biosynthesis from prokaryotes to plants -- Engineered maize hybrids with diverse carotenoid profiles and potential applications in animal feeding -- Carotenoid biosynthesis in liverworts -- Metabolic engineeringforcarotenoid productionusing eukaryotic microalgae and prokaryotic cyanobacteria -- Xanthophyllomycesdendrorhous, a versatile platform for the production of carotenoids and other acetyl-CoA derived compounds -- Carotenoid production in oleaginous yeasts -- Haloarchaea: a promising biosource for carotenoid production -- Carotenoid biosynthesis in the phylum Actinobacteria -- When carotenoid biosynthesis genes metEscherichia coli - the early days and these days -- Pathway engineering using Escherichia colitoproducecommercialized carotenoids -- Carotenoid production in Escherichia coli– Case of acyclic carotenoids -- Fecal microflora from dragonflies and its microorganisms producing carotenoids -- Carotenoid biosynthesis in animals -Case of arthropods -- Part II -- Molecular mechanisms of nonalcholic fatty liver disease (NAFLD)/ nonalcoholic steatohepatitis (NASH) -- Prevention of NAFLD/NASH by astaxanthin and β-cryptoxanthin Therapeutic potential of astaxanthin in diabetic kidney disease -- Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human -- β-Cryptoxanthin from Satsuma mandarin and its multiple functions Health-promoting functions of the marine carotenoid fucoxanthin -- Biological activities of paprika carotenoids, capsanthin and capsorubin.
    Abstract: This book provides a comprehensive overview of carotenoid biosynthesis by different organisms, including bacteria, archaea, fungi, arthropods, and plants. Carotenoids are thought to provide health benefits in areas such as cancer, diabetes, osteoporosis, NAFLD, NASH, obesity, age-related functional decline, and as a result, they have received an increasing amount of attention. With contributions from leading experts in biology, biotechnology, and chemistry of carotenoid research, this volume discusses the biological functions of carotenoids such as astaxanthin, β-cryptoxanthin, and fucoxanthin, in addition to paprika carotenoids, capsanthin, and capsorubin. It also reveals the technologies behind the commercial production of some functional carotenoids. The book is targeted for academic and industrial readers in biology, biotechnology, nutrient physiology and related fields.
    Type of Medium: Online Resource
    Pages: XI, 293 p. 165 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811573606
    Series Statement: Advances in Experimental Medicine and Biology, 1261
    URL: https://doi.org/10.1007/978-981-15-7360-6
    DOI: 10.1007/978-981-15-7360-6
    DDC: 572
    Language: English
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    E-BOOKS (AWI ONLY)
  • 2
    Electronic Resource
    Electronic Resource
    Elevation of the provitamin A content of transgenic tomato plants (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 666-669 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Tomato products are the principal dietary sources of lycopene and major source of β-carotene, both of which have been shown to benefit human health. To enhance the carotenoid content and profile of tomato fruit, we have produced transgenic lines containing a bacterial carotenoid gene (crtI) ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/76523
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  • 3
    Electronic Resource
    Electronic Resource
    New functional assignment of the carotenogenic genes crtB and crtE with constructs of these genes from Erwinia species (1992)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 90 (1992), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract The role of carotenoid genes crtB and crtE has been functionally assigned. These genes were cloned from Erwinia into Escherichia coli or Agrobacterium tumefaciens. Their functions were elucidated by assaying early isoprenoid enzymes involved in phytoene formation. In vitro reactions from extracts of E. coli carrying the crtE gene or a complete carotenogenic gene cluster in which crtB was deleted showed an elevated conversion of farnesyl pyrophosphate (FPP) into geranylgeranyl pyrophosphate (GGPP). These results strongly indicate that the crtE gene encodes GGPP synthase. Introduction of the crtB gene into A. tumefaciens led to the conversion of GGPP into phytoene. This activity was absent in similar transformants with the crtE gene. Thus, the crtB probably encodes phytoene synthase, which was further supported by demonstration that phytoene accumulated in E. coli harboring both the crtB genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1992.tb05162.x
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  • 4
    Electronic Resource
    Electronic Resource
    Expression in Escherichia coli and properties of the carotene ketolase from Haematococcus pluvialis (1996)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 140 (1996), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract High level expression of the functional β-carotene ketolase gene bkt from Haematococcus pluvialis occurred in Escherichia coli transformants producing β-carotene or zeaxanthin as a result of the presence of additional carotenoid genes from Erwinia uredovora. Requirement of molecular oxygen for the insertion of the keto group was demonstrated. The final product of this two-step ketolase reaction from β-carotene is canthaxanthin (4,4′-diketo-β-carotene) with the 4-monoketo derivative echinenone as an intermediate. A reaction sequence for the formation of astaxanthin from β-carotene was established based on kinetic data on astaxanthin formation in E. coli transformants carrying the hydroxylase gene crtZ from Erwinia along with bkt. We conclude that the carotenoids zeaxanthin and adonixanthin which accumulate in addition to astaxanthin in this transformant are products of side reactions rather than direct precursors of astaxanthin. The possible mechanisms for the formation of the keto derivatives are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1996.tb08343.x
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  • 5
    Electronic Resource
    Electronic Resource
    Oil body formation in Euphorbia tirucalli L. cell suspension cultures (1984)
    Springer
    Plant cell reports 3 (1984), S. 21-22 
    Details
    ISSN: 1432-203X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The culture of cells of Euphorbia tirucalli L. resulted in the formation of intracellular particles which osmium tetroxide staining and electron microscopy indicated to be oil bodies. Chemical analysis (TLC, HPLC, GLC and GC-MS) disclosed steroids, triterpenoids, and diterpenoids as the major oil components of the cultured cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00270222
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  • 6
    Electronic Resource
    Electronic Resource
    A novel carotenoid biosynthesis gene coding for ζ-carotene desaturase: functional expression, sequence and phylogenetic origin (1994)
    Springer
    Plant molecular biology 24 (1994), S. 369-379 
    Details
    ISSN: 1573-5028
    Keywords: Anabaena PCC 7120 ; carotenoid biosynthesis ; ζ-carotene desaturase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A DNA fragment which has been isolated previously from an Anabaena DNA expression library was subcloned. The corresponding protein was overexpressed in Escherichia coli. The recombinant enzyme was fully active in converting ζ-carotene into lycopene in vitro with neurosporene as an intermediate. A smaller fragment which still contained the active enzyme was sequenced. An open reading frame of 1497 bp was found coding for a protein consisting of 499 amino acids with the calculated molecular weight of 56 740. In a computer search of nucleotide sequences contained in the EMBL nucleotide sequence library, all the best-fitting comparisons were carotenoid desaturases. The highest similarity was found with the crtI phytoene desaturase genes of bacteria and the al-1 gene from Neurospora crassa. A much lower similarity was found with the pds genes coding for phytoene desaturase from cyanobacteria and higher plants. It is shown in protein similarity plots that the amino acid similarity of ζ-carotene desaturase to the latter is mainly limited to the N terminus of the polypeptides. In contrast, the protein similarity plots and a comparison of a conserved region clearly demonstrate that there is a strong relationship between ζ-carotene desaturase and the phytoene desaturases from various bacteria and fungi. Therefore we propose that the ζ-carotene desaturase gene is homologous to the crt I phytoene desaturase genes of bacteria and fungi.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00020174
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  • 7
    Electronic Resource
    Electronic Resource
    Isolation and functional identification of a novel cDNA for astaxanthin biosynthesis from Haematococcus pluvialis, and astaxanthin synthesis in Escherichia coli (1995)
    Springer
    Plant molecular biology 29 (1995), S. 343-352 
    Details
    ISSN: 1573-5028
    Keywords: astaxanthin ; canthaxanthin ; carotenoid ; xanthophyll ; Haematococcus pluvialis ; green alga
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We succeeded in isolating a novel cDNA involved in astaxanthin biosynthesis from the green alga Haematococcus pluvialis, by an expression cloning method using an Escherichia coli transformant as a host that synthesizes β-carotene due to the Erwinia uredovora carotenoid biosynthesis genes. The cloned cDNA was shown to encode a novel enzyme, β-carotene ketolase (β-carotene oxygenase), which converted β-carotene to canthaxanthin via echinenone, through chromatographic and spectroscopic analysis of the pigments accumulated in an E. coli transformant. This indicates that the encoded enzyme is responsible for the direct conversion of methylene to keto groups, a mechanism that usually requires two different enzymatic reactions proceeding via a hydroxy intermediate. Northern blot analysis showed that the mRNA was synthesized only in the cyst cells of H. pluvialis. E. coli carrying the H. pluvialis cDNA and the E. uredovora genes required for zeaxanthin biosynthesis was also found to synthesize astaxanthin (3S, 3′S), which was identified after purification by a variety of spectroscopic methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00043657
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  • 8
    Electronic Resource
    Electronic Resource
    Production of lycopene by the food yeast, Candida utilis that does not naturally synthesize carotenoid (1998)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 58 (1998), S. 306-308 
    Details
    ISSN: 0006-3592
    Keywords: lycopene ; Candida utilis ; carotenoids ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The Erwinia uredovora crtE, crtB, and crtI genes, which are responsible for the synthesis of carotenoid lycopene from farnesyl pyrophosphate, were expressed in Candida utilis under the control of the promoters and terminators derived from the C. utilis GAP, PGK, and PMA genes, respectively. The yeast transformant carrying the carotenoid biosynthesis genes produced 758 μg/g dry weight of lycopene along with 407 μg/g dry weight of phytoene in the stationary phase. It was observed in the C. utilis transformant that ergosterol content was decreased to 65% of that in the parent strain that accumulated 6.04 mg/g dry weight of ergosterol. It is therefore possible that the carbon flux for the ergosterol biosynthesis has been branched at farnesyl pyrophosphate to generate a new pathway for the lycopene production in this yeast transformant. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 58:306-308, 1998.
    Additional Material: 1 Ill.
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  • 9
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    Synthesis of highly hydroxylated aromatics by evolved biphenyl dioxygenase and subsequent dihydrodiol dehydrogenase (2007)
    Springer
    Details
    Publication Date: 2007-03-31
    Print ISSN: 0175-7598
    Electronic ISSN: 1432-0614
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Springer
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  • 10
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    Rare carotenoids, (3R)-saproxanthin and (3R,2′S)-myxol, isolated from novel marine bacteria (Flavobacteriaceae) and their antioxidative activities (2007)
    Springer
    Details
    Publication Date: 2007-04-01
    Print ISSN: 0175-7598
    Electronic ISSN: 1432-0614
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Springer
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