Publication Date:
1999-07-10
Description:
The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS expression on human monocytes could be up-regulated by interferon-gamma. Soluble BLyS functioned as a potent B cell growth factor in costimulation assays. Administration of soluble recombinant BLyS to mice disrupted splenic B and T cell zones and resulted in elevated serum immunoglobulin concentrations. The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moore, P A -- Belvedere, O -- Orr, A -- Pieri, K -- LaFleur, D W -- Feng, P -- Soppet, D -- Charters, M -- Gentz, R -- Parmelee, D -- Li, Y -- Galperina, O -- Giri, J -- Roschke, V -- Nardelli, B -- Carrell, J -- Sosnovtseva, S -- Greenfield, W -- Ruben, S M -- Olsen, H S -- Fikes, J -- Hilbert, D M -- New York, N.Y. -- Science. 1999 Jul 9;285(5425):260-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10398604" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
B-Cell Activating Factor
;
B-Cell Activation Factor Receptor
;
B-Lymphocyte Subsets/immunology
;
B-Lymphocytes/*immunology
;
Cell Line
;
Cells, Cultured
;
Humans
;
Immunoglobulins/blood
;
Interferon-gamma/pharmacology
;
*Lymphocyte Activation
;
Membrane Proteins/chemistry/genetics/pharmacology/*physiology
;
Mice
;
Mice, Inbred BALB C
;
Molecular Sequence Data
;
Monocytes/*immunology
;
Receptors, Cytokine/metabolism
;
Receptors, Tumor Necrosis Factor/metabolism
;
Recombinant Proteins/pharmacology
;
Sequence Alignment
;
Species Specificity
;
Tumor Necrosis Factor-alpha/chemistry/genetics/pharmacology/*physiology
;
Up-Regulation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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