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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2000-02-26
    Description: Most, if not all, epithelial tissues contain stem cells. They are responsible for normal tissue renewal or for regeneration following damage. Our present knowledge of their properties is limited and is mainly derived from studies of cell kinetics and from clonal analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slack, J M -- New York, N.Y. -- Science. 2000 Feb 25;287(5457):1431-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK. j.m.w.slack@bath.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10688782" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Differentiation ; *Cell Division ; Clone Cells/cytology/physiology ; Embryo, Mammalian/cytology ; Epithelial Cells/*cytology/pathology/physiology ; Humans ; Metaplasia ; Regeneration ; Stem Cells/*cytology/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-12-06
    Description: The development of individual organs in animal embryos involves the formation of tissue-specific stem cells that sustain cell renewal of their own tissue for the lifetime of the organism. Although details of their origin are not always known, tissue-specific stem cells usually share the expression of key transcription factors with cells of the embryonic rudiment from which they arise, and are probably in a similar developmental state. On the other hand, the isolation of pluripotent stem cells from the postnatal organism has encouraged the formulation of models of embryonic and postnatal development that are at variance with the conventional ones. Possible explanations for the existence of such cells, and the issue of whether they also exist in vivo, are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slack, J M W -- G0300415/Medical Research Council/United Kingdom -- G0500220/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2008 Dec 5;322(5907):1498-501. doi: 10.1126/science.1162782.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stem Cell Institute, University of Minnesota, McGuire Translational Research Facility, 2001 6th Street SE, Minneapolis, MN 55455, USA. slack017@umn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19056975" target="_blank"〉PubMed〈/a〉
    Keywords: Adult Stem Cells/cytology/physiology ; Animals ; Cell Differentiation ; Cell Lineage ; Cell Separation ; Cell Transdifferentiation ; Cells, Cultured ; Embryonic Stem Cells/cytology/physiology ; Humans ; Models, Biological ; Neural Crest/cytology ; *Organogenesis ; Pluripotent Stem Cells/cytology/physiology ; Stem Cell Niche ; Stem Cells/cytology/*physiology ; Transcription Factors/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2011-05-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slack, Jonathan M W -- New York, N.Y. -- Science. 2011 May 13;332(6031):799-800. doi: 10.1126/science.1206913.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stem Cell Institute, The University of Minnesota, 2001 6th Street SE, Minneapolis, MN 55455, USA. slack017@umn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21566180" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cell Separation ; Cell Survival ; Flow Cytometry ; Gene Expression ; Genes, Helminth ; Head ; Helminth Proteins/genetics/metabolism ; Hydrolases/genetics/metabolism ; Planarians/*cytology/*physiology ; Pluripotent Stem Cells/cytology/*physiology ; *Regeneration ; Signal Transduction ; Tail ; Wnt Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 326 (1987), S. 197-200 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the main series of experiments, explants of ectoderm were cut from the animal pole region of stage 8 Xenopus blastulae (about 1,024-2,048 cell stage6) and exposed to bFGF. At stage 8 the explants include about 50-100 cells, but the cell number continues to increase by cleavage divisions without ...
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 271 (1978), S. 760-761 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The model comprises two basic rules which determine whether a particular part of an organ will regenerate and which structures will be formed if it does so. The first rule is that of 'shortest intercalation' and states that when tissues of different positional values are brought together then the ...
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 261 (1976), S. 44-46 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Diagram of the reduplication-inducing graft described in the text. Operations were performed with electrolytically sharpened tungsten needles. The embryos were in half-strength Holtfreter solution containing 1/3,000 MS222 (Sandoz). The grafts were kept in place for 1?2 h with glass bridges. ...
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 327 (1987), S. 553-554 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE first moiphogen has been identified and it is reiinoic acid. Of course nothing in science is really certain, so perhaps I should say that the article by Thaller and Eichele on page 625 of this issue1 com-pletes a strong prima fade case for the identity of the first moiphogen. So what is a ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 354 (1991), S. 26-26 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SLACK REPLIES - How can we know whether a molecule is really acting as a morphogen? Like many others I have spent some time thinking about this and have published a set of possible criteria . To simplify these somewhat: the substance should have the expected biological activity; ...
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 347 (1990), S. 420-420 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR-Many of us must wonder what pro-portion of the references that adorn scien-tific papers have actually been look up, let alone read and inwardly digested. An example has recently come to my atten-tion of the creation of an entirely new scientific personality as a result of casual citation. A ...
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 371 (1994), S. 477-478 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ON page 487 of this issue1, John Gurdon and colleagues describe how they have taken a fresh look at how morphogenetic gradients work in the early stages of animal development. The gradient is an idea of long standing. It goes back to the experiments of Child in the early years of the present ...
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