Publication Date:
2008-12-06
Description:
The development of individual organs in animal embryos involves the formation of tissue-specific stem cells that sustain cell renewal of their own tissue for the lifetime of the organism. Although details of their origin are not always known, tissue-specific stem cells usually share the expression of key transcription factors with cells of the embryonic rudiment from which they arise, and are probably in a similar developmental state. On the other hand, the isolation of pluripotent stem cells from the postnatal organism has encouraged the formulation of models of embryonic and postnatal development that are at variance with the conventional ones. Possible explanations for the existence of such cells, and the issue of whether they also exist in vivo, are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slack, J M W -- G0300415/Medical Research Council/United Kingdom -- G0500220/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2008 Dec 5;322(5907):1498-501. doi: 10.1126/science.1162782.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stem Cell Institute, University of Minnesota, McGuire Translational Research Facility, 2001 6th Street SE, Minneapolis, MN 55455, USA. slack017@umn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19056975" target="_blank"〉PubMed〈/a〉
Keywords:
Adult Stem Cells/cytology/physiology
;
Animals
;
Cell Differentiation
;
Cell Lineage
;
Cell Separation
;
Cell Transdifferentiation
;
Cells, Cultured
;
Embryonic Stem Cells/cytology/physiology
;
Humans
;
Models, Biological
;
Neural Crest/cytology
;
*Organogenesis
;
Pluripotent Stem Cells/cytology/physiology
;
Stem Cell Niche
;
Stem Cells/cytology/*physiology
;
Transcription Factors/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink