Abstract
WE report here a result which is in contradiction to the ‘clock face model’ for the regeneration of animal organs. This model1,2 is based on the behaviour of insect appendages, imaginal disks and the amphibian limb. It involves treating the organ as a surface on which cells are assigned positional information in terms of a radial and an angular variable. In the case of the amphibian limb, this surface corresponds to the hollow surface of limb dermis and muscle, so that the ‘radial’ positional values run from the body to the tip of the digits, while the ‘angular’ values run around the circumference.
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References
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SLACK, J., SAVAGE, S. Regeneration of reduplicated limbs in contravention of the complete circle rule. Nature 271, 760–761 (1978). https://doi.org/10.1038/271760a0
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DOI: https://doi.org/10.1038/271760a0
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