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  • 1
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    Generalized potential of adult neural stem cells (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-06-02
    Description: The differentiation potential of stem cells in tissues of the adult has been thought to be limited to cell lineages present in the organ from which they were derived, but there is evidence that some stem cells may have a broader differentiation repertoire. We show here that neural stem cells from the adult mouse brain can contribute to the formation of chimeric chick and mouse embryos and give rise to cells of all germ layers. This demonstrates that an adult neural stem cell has a very broad developmental capacity and may potentially be used to generate a variety of cell types for transplantation in different diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clarke, D L -- Johansson, C B -- Wilbertz, J -- Veress, B -- Nilsson, E -- Karlstrom, H -- Lendahl, U -- Frisen, J -- New York, N.Y. -- Science. 2000 Jun 2;288(5471):1660-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Molecular Biology, Medical Nobel Institute, Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10834848" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastocyst/cytology/physiology ; Brain/*cytology ; Cell Aggregation ; *Cell Differentiation ; Cell Lineage ; Cells, Cultured ; Chick Embryo ; Coculture Techniques ; Ectoderm/cytology ; Embryonic and Fetal Development ; Endoderm/cytology ; Liver/cytology/embryology ; Mesoderm/cytology ; Mice ; Microinjections ; Morula/cytology/physiology ; Muscles/cytology/embryology ; Stem Cell Transplantation ; Stem Cells/*cytology/physiology ; Transplantation Chimera
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Dynamics of fat cell turnover in humans (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-05-06
    Description: Obesity is increasing in an epidemic manner in most countries and constitutes a public health problem by enhancing the risk for cardiovascular disease and metabolic disorders such as type 2 diabetes. Owing to the increase in obesity, life expectancy may start to decrease in developed countries for the first time in recent history. The factors determining fat mass in adult humans are not fully understood, but increased lipid storage in already developed fat cells (adipocytes) is thought to be most important. Here we show that adipocyte number is a major determinant for the fat mass in adults. However, the number of fat cells stays constant in adulthood in lean and obese individuals, even after marked weight loss, indicating that the number of adipocytes is set during childhood and adolescence. To establish the dynamics within the stable population of adipocytes in adults, we have measured adipocyte turnover by analysing the integration of 14C derived from nuclear bomb tests in genomic DNA. Approximately 10% of fat cells are renewed annually at all adult ages and levels of body mass index. Neither adipocyte death nor generation rate is altered in early onset obesity, suggesting a tight regulation of fat cell number in this condition during adulthood. The high turnover of adipocytes establishes a new therapeutic target for pharmacological intervention in obesity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spalding, Kirsty L -- Arner, Erik -- Westermark, Pal O -- Bernard, Samuel -- Buchholz, Bruce A -- Bergmann, Olaf -- Blomqvist, Lennart -- Hoffstedt, Johan -- Naslund, Erik -- Britton, Tom -- Concha, Hernan -- Hassan, Moustapha -- Ryden, Mikael -- Frisen, Jonas -- Arner, Peter -- RR13461/RR/NCRR NIH HHS/ -- England -- Nature. 2008 Jun 5;453(7196):783-7. doi: 10.1038/nature06902. Epub 2008 May 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden. kirsty.spalding@ki.se〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18454136" target="_blank"〉PubMed〈/a〉
    Keywords: Adipocytes/*cytology ; Adipose Tissue/anatomy & histology/*cytology ; Adult ; Body Mass Index ; Carbon Radioisotopes ; Cell Count ; Cell Death ; Cell Size ; Humans ; Obesity/pathology ; Stem Cells/*cytology ; Weight Loss
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Resident neural stem cells restrict tissue damage and neuronal loss after spinal cord injury in mice (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-02
    Description: Central nervous system injuries are accompanied by scar formation. It has been difficult to delineate the precise role of the scar, as it is made by several different cell types, which may limit the damage but also inhibit axonal regrowth. We show that scarring by neural stem cell-derived astrocytes is required to restrict secondary enlargement of the lesion and further axonal loss after spinal cord injury. Moreover, neural stem cell progeny exerts a neurotrophic effect required for survival of neurons adjacent to the lesion. One distinct component of the glial scar, deriving from resident neural stem cells, is required for maintaining the integrity of the injured spinal cord.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sabelstrom, Hanna -- Stenudd, Moa -- Reu, Pedro -- Dias, David O -- Elfineh, Marta -- Zdunek, Sofia -- Damberg, Peter -- Goritz, Christian -- Frisen, Jonas -- New York, N.Y. -- Science. 2013 Nov 1;342(6158):637-40. doi: 10.1126/science.1242576.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24179227" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Apoptosis ; Astrocytes/physiology ; Axons/*physiology ; Cell Survival ; Cicatrix/*pathology ; Forkhead Transcription Factors/genetics ; Genes, ras ; Mice ; Mice, Mutant Strains ; Neural Stem Cells/*physiology ; Spinal Cord Injuries/*pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Neuroscience. Why adults need new brain cells (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bergmann, Olaf -- Frisen, Jonas -- New York, N.Y. -- Science. 2013 May 10;340(6133):695-6. doi: 10.1126/science.1237976.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23661750" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Behavior, Animal ; Female ; Hippocampus/*embryology ; *Individuality ; Male ; *Neurogenesis ; Neuronal Plasticity/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-02-17
    Description: The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Curtis, Maurice A -- Kam, Monica -- Nannmark, Ulf -- Anderson, Michelle F -- Axell, Mathilda Zetterstrom -- Wikkelso, Carsten -- Holtas, Stig -- van Roon-Mom, Willeke M C -- Bjork-Eriksson, Thomas -- Nordborg, Claes -- Frisen, Jonas -- Dragunow, Michael -- Faull, Richard L M -- Eriksson, Peter S -- New York, N.Y. -- Science. 2007 Mar 2;315(5816):1243-9. Epub 2007 Feb 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17303719" target="_blank"〉PubMed〈/a〉
    Keywords: Apoptosis ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cell Differentiation ; Cell Movement ; Cell Nucleus/chemistry/ultrastructure ; Cell Shape ; Ependyma/cytology ; Eye Proteins/genetics ; Homeodomain Proteins/genetics ; Humans ; Lateral Ventricles/anatomy & histology/*cytology ; Magnetic Resonance Imaging ; Microscopy, Electron ; Microtubule-Associated Proteins/genetics ; Nerve Tissue Proteins/genetics ; Neural Cell Adhesion Molecule L1/analysis ; Neurons/chemistry/cytology/*physiology/ultrastructure ; Neuropeptides/genetics ; Olfactory Bulb/anatomy & histology/*cytology ; Olfactory Pathways/anatomy & histology/*cytology ; Paired Box Transcription Factors/genetics ; Prosencephalon/anatomy & histology/*cytology ; Repressor Proteins/genetics ; Sialic Acids/analysis ; Stem Cells/chemistry/cytology/*physiology/ultrastructure ; Tubulin/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Evidence for cardiomyocyte renewal in humans (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-04-04
    Description: It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991140/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991140/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bergmann, Olaf -- Bhardwaj, Ratan D -- Bernard, Samuel -- Zdunek, Sofia -- Barnabe-Heider, Fanie -- Walsh, Stuart -- Zupicich, Joel -- Alkass, Kanar -- Buchholz, Bruce A -- Druid, Henrik -- Jovinge, Stefan -- Frisen, Jonas -- P41 GM103483/GM/NIGMS NIH HHS/ -- P41 RR013461/RR/NCRR NIH HHS/ -- P41 RR013461-11/RR/NCRR NIH HHS/ -- RR13461/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2009 Apr 3;324(5923):98-102. doi: 10.1126/science.1164680.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19342590" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Aging ; Carbon Radioisotopes/analysis ; Cell Count ; Cell Nucleus/chemistry ; Cell Nucleus Division ; Cell Proliferation ; Cell Separation ; DNA/*biosynthesis ; Echocardiography, Doppler, Color ; Humans ; Middle Aged ; Models, Cardiovascular ; Myocytes, Cardiac/*cytology/metabolism ; Nuclear Weapons ; Polyploidy ; Radiometric Dating ; Stem Cells/cytology ; Troponin I/analysis ; Troponin T/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    A pericyte origin of spinal cord scar tissue (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-09
    Description: There is limited regeneration of lost tissue after central nervous system injury, and the lesion is sealed with a scar. The role of the scar, which often is referred to as the glial scar because of its abundance of astrocytes, is complex and has been discussed for more than a century. Here we show that a specific pericyte subtype gives rise to scar-forming stromal cells, which outnumber astrocytes, in the injured spinal cord. Blocking the generation of progeny by this pericyte subtype results in failure to seal the injured tissue. The formation of connective tissue is common to many injuries and pathologies, and here we demonstrate a cellular origin of fibrosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goritz, Christian -- Dias, David O -- Tomilin, Nikolay -- Barbacid, Mariano -- Shupliakov, Oleg -- Frisen, Jonas -- 250297/European Research Council/International -- New York, N.Y. -- Science. 2011 Jul 8;333(6039):238-42. doi: 10.1126/science.1203165.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21737741" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytes/pathology/physiology ; Blood Vessels/pathology ; Cell Count ; Cell Proliferation ; Cicatrix/*pathology ; Fibrosis ; Mice ; Mice, Transgenic ; Pericytes/*pathology/physiology ; Spinal Cord/blood supply/*pathology ; Spinal Cord Injuries/*pathology ; Stromal Cells/pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-10-11
    Description: Neurogenesis is restricted in the adult mammalian brain; most neurons are neither exchanged during normal life nor replaced in pathological situations. We report that stroke elicits a latent neurogenic program in striatal astrocytes in mice. Notch1 signaling is reduced in astrocytes after stroke, and attenuated Notch1 signaling is necessary for neurogenesis by striatal astrocytes. Blocking Notch signaling triggers astrocytes in the striatum and the medial cortex to enter a neurogenic program, even in the absence of stroke, resulting in 850 +/- 210 (mean +/- SEM) new neurons in a mouse striatum. Thus, under Notch signaling regulation, astrocytes in the adult mouse brain parenchyma carry a latent neurogenic program that may potentially be useful for neuronal replacement strategies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Magnusson, Jens P -- Goritz, Christian -- Tatarishvili, Jemal -- Dias, David O -- Smith, Emma M K -- Lindvall, Olle -- Kokaia, Zaal -- Frisen, Jonas -- New York, N.Y. -- Science. 2014 Oct 10;346(6206):237-41. doi: 10.1126/science.346.6206.237. Epub 2014 Oct 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden. ; Lund Stem Cell Center, University Hospital, SE-221 84 Lund, Sweden. ; Division of Translational Cancer Research, Lund University, SE-223 63 Lund, Sweden. ; Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden. jonas.frisen@ki.se.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25301628" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astrocytes/cytology/*physiology ; Corpus Striatum/pathology/physiopathology ; Gene Deletion ; Immunoglobulin J Recombination Signal Sequence-Binding Protein/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neural Stem Cells/cytology/*physiology ; Neurogenesis/genetics/*physiology ; Neurons/cytology/*physiology ; Receptor, Notch1/genetics/*physiology ; *Signal Transduction ; Stroke/pathology/*physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
    Electronic Resource
    Electronic Resource
    Central nervous system stem cells in the embryo and adult (1998)
    Springer
    Cellular and molecular life sciences 54 (1998), S. 935-945 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Development; differentiation; regeneration; neuron; glia.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The central nervous system is generated from neural stem cells during embryonic development. These cells are multipotent and generate neurons, astrocytes and oligodendrocytes. The last few years it has been found that there are populations of stem cells also in the adult mammalian brain and spinal cord. In this paper, we review the recent development in the field of embryonic and adult neural stem cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000180050224
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    Paper (German National Licenses)
    Fulltext
  • 10
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    Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems. (1993)
    National Academy of Sciences
    Details
    Publication Date: 1993-06-01
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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