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  • 1
    Publication Date: 2015-10-20
    Description: Analysis of airborne and terrestrial lidar data demonstrates that 〉0.4 km 3 of magma cooled in sills at shallow (〈 1 km) depth in the now-eroded Pliocene San Rafael Swell distributed volcanic field, Utah (USA). The volumes of each of seven sills are estimated from three-dimensional (3-D) models of the lidar data and range from 10 –4 to 10 –1 km 3 . Directions of magma flow during emplacement are interpreted from precise sill thickness measurements and measurements of linear vertical offsets within the sills, helping to identify feeder conduits and dikes; 3-D map relationships derived from lidar data demonstrate that magma flowed into and out of sills from these active dikes and eruptive conduits. Mapped sill volumes account for 〉92% of intrusive material within the 50 km 2 study area. We conclude that sills played a significant role in modifying eruption dynamics during activity in San Rafael, and suggest that monitoring of sill inflation and deflation in active distributed volcanic fields may provide key information about unrest and potential eruption dynamics.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1991-12-13
    Description: Long-term depression (LTD) in the intact cerebellum is a decrease in the efficacy of the parallel fiber-Purkinje neuron synapse induced by coactivation of climbing fiber and parallel fiber inputs. In cultured Purkinje neurons, a similar depression can be induced by iontophoretic glutamate pulses and Purkinje neuron depolarization. This form of LTD is expressed as a depression of alpha-amino-3-hydroxy-5-methyl-4- isoxazole-propionic acid (AMPA)-mediated current, and its induction is dependent on activation of metabotropic quisqualate receptors. The effect of inhibitors of protein kinase C (PKC) on LTD induction was studied. Inhibitors of PKC blocked LTD induction, while phorbol-12,13-diacetate (PDA), a PKC activator, mimicked LTD. These results suggest that PKC activation is necessary for the induction of cerebellar LTD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Linden, D J -- Connor, J A -- New York, N.Y. -- Science. 1991 Dec 13;254(5038):1656-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurosciences, Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1721243" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/physiology ; Cells, Cultured ; Cerebellum/*physiology ; Enzyme Activation/drug effects ; Ibotenic Acid/analogs & derivatives/pharmacology ; In Vitro Techniques ; *Indoles ; Mice ; *Naphthalenes ; Phorbol Esters/pharmacology ; Polycyclic Compounds/pharmacology ; Protein Kinase C/antagonists & inhibitors/pharmacology/*physiology ; Purkinje Cells/*physiology ; Quisqualic Acid/pharmacology ; Receptors, AMPA ; Receptors, Neurotransmitter/physiology ; Synaptic Membranes/*physiology ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 1996-08-23
    Description: Glutamate and aspartate are endogenous excitatory amino acid neurotransmitters widely distributed in the mammalian central nervous system. Aspartate was shown to induce a large membrane current sensitive to N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists in Purkinje cells from mice lacking functional NMDA receptors (NR1(-/-)). This response was accompanied by high permeability to calcium. In contrast, no current was induced by aspartate in hippocampal neurons and cerebellar granule cells from NR1(-/-) mice. Several other glutamate receptor agonists failed to evoke this response. Thus, in Purkinje cells, aspartate activates a distinct response capable of contributing to synaptic plasticity through calcium permeability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yuzaki, M -- Forrest, D -- Curran, T -- Connor, J A -- P30CA21765/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1996 Aug 23;273(5278):1112-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105-2794, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8688099" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aspartic Acid/*pharmacology ; Calcium/*metabolism ; Cerebellum/cytology/metabolism ; Excitatory Amino Acid Agonists/pharmacology ; Excitatory Amino Acid Antagonists/pharmacology ; Glutamic Acid/pharmacology ; Hippocampus/cytology/metabolism ; Homocysteine/analogs & derivatives/pharmacology ; Magnesium/pharmacology ; Mice ; Mice, Knockout ; N-Methylaspartate/pharmacology ; Neuronal Plasticity ; Neurons/drug effects/metabolism ; Patch-Clamp Techniques ; Permeability ; Purkinje Cells/drug effects/*metabolism ; Receptors, Amino Acid/drug effects/*metabolism ; Receptors, N-Methyl-D-Aspartate/agonists/antagonists & inhibitors/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 1988-11-04
    Description: Microfluorometric imaging was used to study the correlation of intracellular calcium concentration with voltage-dependent electrical activity in guinea pig cerebellar Purkinje cells. The spatiotemporal dynamics of intracellular calcium concentration are demonstrated during spontaneous and evoked activity. The results are in agreement with hypotheses of dendritic segregation of calcium conductances suggested by electrophysiological experiments. These in vitro slice fluorescence imaging methods are applicable to a wide range of problems in central nervous system biochemical and electrophysiological functions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tank, D W -- Sugimori, M -- Connor, J A -- Llinas, R R -- NS-13742/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1988 Nov 4;242(4879):773-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Biophysics Research Department, AT&T Bell Laboratories, Murray Hill, NJ 07974.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2847315" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzofurans ; Calcium/*physiology ; Calcium Channels/*physiology ; Dendrites/*physiology ; Fura-2 ; Guinea Pigs ; Image Processing, Computer-Assisted ; In Vitro Techniques ; Membrane Potentials ; Neurotoxins/pharmacology ; Periodicity ; Purkinje Cells/*physiology ; Spider Venoms/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 1983-02-18
    Description: Injections of cyclic adenosine monophosphate into molluscan neurons often produce a transient membrane depolarization. By using the calcium indicator dye arsenazo III, it was found that cyclic nucleotide injections into neurons of Archidoris montereyensis resulted in elevation of internal calcium concentrations. However, this was demonstrated to be a secondary consequence of an induced increase in membrane sodium permeability, and not due to any direct effect of cyclic adenosine monophosphate on cellular calcium influx or internal calcium regulating processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hockberger, P -- Connor, J A -- GMO-7143/GM/NIGMS NIH HHS/ -- NS-15186/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Feb 18;219(4586):869-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6297009" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arsenazo III ; Calcium/*metabolism ; Cyclic AMP/*metabolism ; Cytoplasm/metabolism ; Membrane Potentials ; Mollusca ; Neurons/metabolism ; Sodium/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 1988-04-29
    Description: Spatially resolved measurements of intracellular free calcium and of the changes produced by excitatory amino acids were made in neurons isolated from adult mammalian brain. Extremely long-lasting (minutes) Ca2+ gradients were induced in the apical dendrites of hippocampal CA1 neurons after brief (1 to 3 seconds), local application of either glutamate or N-methyl-D-aspartate (NMDA). These gradients reflect the continuous flux of Ca2+ into the dendrite. The sustained gradients, but not the immediate transient response to the agonists, were prevented by prior treatment with the protein kinase C inhibitor sphingosine. Expression of the long-lasting Ca2+ gradients generally required a priming or conditioning stimulus with the excitatory agonist. The findings demonstrate a coupling between NMDA receptor activation and long-lasting intracellular Ca2+ elevation that could contribute to certain use-dependent modifications of synaptic responses in hippocampal CA1 neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Connor, J A -- Wadman, W J -- Hockberger, P E -- Wong, R K -- NS24519/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1988 Apr 29;240(4852):649-53.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉AT&T Bell Laboratories, Murray Hill, NJ 07974.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2452481" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/*pharmacology ; Animals ; Aspartic Acid/analogs & derivatives/pharmacology ; Benzofurans ; Calcium/*metabolism ; Dendrites/*metabolism ; Fluorescent Dyes ; Fura-2 ; Glutamates/pharmacology ; Glutamic Acid ; Guinea Pigs ; Hippocampus/drug effects/*metabolism ; Ion Channels/drug effects/metabolism ; Magnesium/pharmacology ; Membrane Potentials/drug effects ; N-Methylaspartate ; Neurons/drug effects/*metabolism ; Potassium/metabolism ; Protein Kinase C/antagonists & inhibitors ; Sphingosine/pharmacology ; Tetrodotoxin/pharmacology ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Inorganic chemistry 16 (1977), S. 1392-1396 
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 100 (1978), S. 7738-7739 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 635 (1991), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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