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  • 1
    Publication Date: 2011-10-25
    Description: The tip of a projectile point made of mastodon bone is embedded in a rib of a single disarticulated mastodon at the Manis site in the state of Washington. Radiocarbon dating and DNA analysis show that the rib is associated with the other remains and dates to 13,800 years ago. Thus, osseous projectile points, common to the Beringian Upper Paleolithic and Clovis, were made and used during pre-Clovis times in North America. The Manis site, combined with evidence of mammoth hunting at sites in Wisconsin, provides evidence that people were hunting proboscideans at least two millennia before Clovis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Waters, Michael R -- Stafford, Thomas W Jr -- McDonald, H Gregory -- Gustafson, Carl -- Rasmussen, Morten -- Cappellini, Enrico -- Olsen, Jesper V -- Szklarczyk, Damian -- Jensen, Lars Juhl -- Gilbert, M Thomas P -- Willerslev, Eske -- New York, N.Y. -- Science. 2011 Oct 21;334(6054):351-3. doi: 10.1126/science.1207663.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for the Study of the First Americans, Department of Anthropology, Texas A&M University, 4352 TAMU, College Station, TX 77843-4352, USA. mwaters@tamu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22021854" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Archaeology ; Bone and Bones ; Geologic Sediments ; History, Ancient ; Humans ; Male ; *Mastodons ; Radiometric Dating ; Time ; Washington ; Weapons/*history
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2011-11-04
    Description: Despite decades of research, the roles of climate and humans in driving the dramatic extinctions of large-bodied mammals during the Late Quaternary period remain contentious. Here we use ancient DNA, species distribution models and the human fossil record to elucidate how climate and humans shaped the demographic history of woolly rhinoceros, woolly mammoth, wild horse, reindeer, bison and musk ox. We show that climate has been a major driver of population change over the past 50,000 years. However, each species responds differently to the effects of climatic shifts, habitat redistribution and human encroachment. Although climate change alone can explain the extinction of some species, such as Eurasian musk ox and woolly rhinoceros, a combination of climatic and anthropogenic effects appears to be responsible for the extinction of others, including Eurasian steppe bison and wild horse. We find no genetic signature or any distinctive range dynamics distinguishing extinct from surviving species, emphasizing the challenges associated with predicting future responses of extant mammals to climate and human-mediated habitat change.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070744/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070744/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lorenzen, Eline D -- Nogues-Bravo, David -- Orlando, Ludovic -- Weinstock, Jaco -- Binladen, Jonas -- Marske, Katharine A -- Ugan, Andrew -- Borregaard, Michael K -- Gilbert, M Thomas P -- Nielsen, Rasmus -- Ho, Simon Y W -- Goebel, Ted -- Graf, Kelly E -- Byers, David -- Stenderup, Jesper T -- Rasmussen, Morten -- Campos, Paula F -- Leonard, Jennifer A -- Koepfli, Klaus-Peter -- Froese, Duane -- Zazula, Grant -- Stafford, Thomas W Jr -- Aaris-Sorensen, Kim -- Batra, Persaram -- Haywood, Alan M -- Singarayer, Joy S -- Valdes, Paul J -- Boeskorov, Gennady -- Burns, James A -- Davydov, Sergey P -- Haile, James -- Jenkins, Dennis L -- Kosintsev, Pavel -- Kuznetsova, Tatyana -- Lai, Xulong -- Martin, Larry D -- McDonald, H Gregory -- Mol, Dick -- Meldgaard, Morten -- Munch, Kasper -- Stephan, Elisabeth -- Sablin, Mikhail -- Sommer, Robert S -- Sipko, Taras -- Scott, Eric -- Suchard, Marc A -- Tikhonov, Alexei -- Willerslev, Rane -- Wayne, Robert K -- Cooper, Alan -- Hofreiter, Michael -- Sher, Andrei -- Shapiro, Beth -- Rahbek, Carsten -- Willerslev, Eske -- R01 HG003229/HG/NHGRI NIH HHS/ -- England -- Nature. 2011 Nov 2;479(7373):359-64. doi: 10.1038/nature10574.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for GeoGenetics, University of Copenhagen, Oster Voldgade 5-7, DK-1350 Copenhagen K, Denmark.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22048313" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bayes Theorem ; *Biota ; Bison ; Climate Change/*history ; DNA, Mitochondrial/analysis/genetics ; Europe ; *Extinction, Biological ; Fossils ; Genetic Variation ; Geography ; History, Ancient ; Horses ; Human Activities/*history ; Humans ; Mammals/genetics/*physiology ; Mammoths ; Molecular Sequence Data ; Population Dynamics ; Reindeer ; Siberia ; Species Specificity ; Time Factors
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 1996-06-14
    Description: Analyses of fossil mammal faunas from 2945 localities in the United States demonstrate that the geographic ranges of individual species shifted at different times, in different directions, and at different rates in response to late Quaternary environmental fluctuations. The geographic pattern of faunal provinces was similar for the late Pleistocene and late Holocene, but differing environmental gradients resulted in dissimilar species composition for these biogeographic regions. Modern community patterns emerged only in the last few thousand years, and many late Pleistocene communities do not have modern analogs. Faunal heterogeneity was greater in the late Pleistocene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graham -- Lundelius Jr -- Schroeder -- Toomey III -- Anderson -- Barnosky -- Burns -- Churcher -- Grayson -- Guthrie -- Harington -- Jefferson -- Martin -- McDonald -- Morlan -- Semken Jr -- Webb -- Werdelin -- Wilson -- New York, N.Y. -- Science. 1996 Jun 14;272(5268):1601-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉R. W. Graham, M. A. Graham, E. K. Schroeder, and R. S. Toomey III are at Research and Collections Center, Illinois State Museum, 1011 East Ash, Springfield, IL 62703, USA. E. L. Lundelius Jr., Department of Geological Sciences, University of Texas, Austin, TX 78712, USA. E. Anderson, Denver Museum of Natural History, Denver, CO 80205, USA. A. D. Barnosky, Mountain Research Center, Montana State University, Bozeman, MT 59715, USA. J. A. Burns, Provincial Museum of Alberta, Edmonton, Alberta, Canada T5N 0M6. C. S. Churcher, Department of Zoology, University of Toronto, Toronto, Ontario, Canada M5S 1A1. D. K. Grayson, Department of Anthropology, University of Washington, Seattle, WA 98195, USA. R. D. Guthrie, Department of Biology, University of Alaska, Fairbanks, AK 99701, USA. C. R. Harington, Earth Sciences Section (Paleobiology), Canadian Museum of Nature, Ottawa, Ontario, Canada K1P 6P4. G. T. Jefferson, Anza-Borrego Desert State Park, 200 Palm Canyon Drive, Borrego Springs, CA 92004, USA. L. D. Martin, Museum of Natural History, University of Kansas, Lawrence, KS 66045, USA. H. G. McDonald, Hagerman Fossil Beds National Monument, Post Office Box 570, Hagerman, ID 83332, USA. R. E. Morlan, Canadian Museum of Civilization, Post Office Box 3100 Station B, Hull, Quebec, Canada J8X 4H2. H. A. Semken Jr., Department of Geology, University of Iowa, Iowa City, IA 52242, USA. S. D. Webb, Florida Museum of Natural History, University of Florida, Gainesville, FL 32611, USA. L. Werdelin, Department of Paleozoology, Swedish Museum, Box 50007, S-104 05 Stockholm, Sweden. M. C. Wilson, Department of Archaeology, Simon Fraser University, Burnaby, BC, Canada V5A 1S6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8662471" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2015-08-08
    Description: The mechanisms of Late Pleistocene megafauna extinctions remain fiercely contested, with human impact or climate change cited as principal drivers. We compared ancient DNA and radiocarbon data from 31 detailed time series of regional megafaunal extinctions and replacements over the past 56,000 years with standard and new combined records of Northern Hemisphere climate in the Late Pleistocene. Unexpectedly, rapid climate changes associated with interstadial warming events are strongly associated with the regional replacement or extinction of major genetic clades or species of megafauna. The presence of many cryptic biotic transitions before the Pleistocene/Holocene boundary revealed by ancient DNA confirms the importance of climate change in megafaunal population extinctions and suggests that metapopulation structures necessary to survive such repeated and rapid climatic shifts were susceptible to human impacts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cooper, Alan -- Turney, Chris -- Hughen, Konrad A -- Brook, Barry W -- McDonald, H Gregory -- Bradshaw, Corey J A -- New York, N.Y. -- Science. 2015 Aug 7;349(6248):602-6. doi: 10.1126/science.aac4315. Epub 2015 Jul 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, and Environment Institute, University of Adelaide, Adelaide, Australia. alan.cooper@adelaide.edu.au c.turney@unsw.edu.au. ; Climate Change Research Centre and School of Biological, Earth, and Environmental Sciences, University of New South Wales, Sydney, Australia. alan.cooper@adelaide.edu.au c.turney@unsw.edu.au. ; Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA. ; Environment Institute and School of Biological Sciences, University of Adelaide, Adelaide, Australia. School of Biological Sciences, University of Tasmania, Hobart, Australia. ; Museum Management Program, National Parks Service, Fort Collins, CO 80525, USA. ; Environment Institute and School of Biological Sciences, University of Adelaide, Adelaide, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26250679" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA/genetics/history/isolation & purification ; *Extinction, Biological ; Fossils/history ; Global Warming/*history ; History, Ancient ; Humans ; Paleontology ; Population
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 1987-04-10
    Description: A right metacarpal III represents the first North American record of the giant anteater (Myrmecophaga tridactyla). Recovered in northwestern Sonora, Mexico, with a rich vertebrate fauna of early Pleistocene (Irvingtonian) age, it belongs to a cohort of large mammals that dispersed from South America to North America along a savanna corridor. Presumably habitat and climatic changes have subsequently driven this mammalian family more than 3000 kilometers back into Central America from its former expansion into temperate North America.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shaw, C A -- McDonald, H G -- New York, N.Y. -- Science. 1987 Apr 10;236(4798):186-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17789783" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 375 (1995), S. 224-227 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Order Xenarthra Family Megalonychidae Subfamily Nothrotheriinae Thalassocnus natans, gen. et sp. nov. Holotype. MNHN SAS 734 (Museum national d'Histoire naturelle, Paris). A partial skeleton including skull, mandible, cervical, thoracic, lumbar and some caudal ...
    Type of Medium: Electronic Resource
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  • 7
  • 8
    Publication Date: 2015-08-29
    Description: On average, mutations are deleterious to proteins. Mutations conferring new function to a protein often come at the expense of protein folding or stability, reducing overall activity. Over the years, a panel of T7 RNA polymerases have been designed or evolved to accept nucleotides with modified ribose moieties. These modified RNAs have proven useful, especially in vivo , but the transcriptional yields tend to be quite low. Here we show that mutations previously shown to increase the thermal tolerance of T7 RNA polymerase can increase the activity of mutants with expanded substrate range. The resulting polymerase mutants can be used to generate 2' -O- methyl modified RNA with yields much higher than enzymes currently employed.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 9
    Publication Date: 2015-05-27
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
    Published by Royal Society
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  • 10
    Publication Date: 2014-12-31
    Description: Existing radiocarbon (14C) dates on American mastodon (Mammut americanum) fossils from eastern Beringia (Alaska and Yukon) have been interpreted as evidence they inhabited the Arctic and Subarctic during Pleistocene full-glacial times (∼18,000 14C years B.P.). However, this chronology is inconsistent with inferred habitat preferences of mastodons and correlative paleoecological evidence....
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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