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  • 1
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    omiRas: a Web server for differential expression analysis of miRNAs derived from small RNA-Seq data (2013)
    Oxford University Press
    Details
    Publication Date: 2013-10-04
    Description: : Small RNA deep sequencing is widely used to characterize non-coding RNAs (ncRNAs) differentially expressed between two conditions, e.g. healthy and diseased individuals and to reveal insights into molecular mechanisms underlying condition-specific phenotypic traits. The ncRNAome is composed of a multitude of RNAs, such as transfer RNA, small nucleolar RNA and microRNA (miRNA), to name few. Here we present omiRas, a Web server for the annotation, comparison and visualization of interaction networks of ncRNAs derived from next-generation sequencing experiments of two different conditions. The Web tool allows the user to submit raw sequencing data and results are presented as: (i) static annotation results including length distribution, mapping statistics, alignments and quantification tables for each library as well as lists of differentially expressed ncRNAs between conditions and (ii) an interactive network visualization of user-selected miRNAs and their target genes based on the combination of several miRNA–mRNA interaction databases. Availability and Implementation: The omiRas Web server is implemented in Python, PostgreSQL, R and can be accessed at: http://tools.genxpro.net/omiras/ . Contact: rotter@genxpro.de Supplementary Information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 2
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    Infrared absorption on a complex comprising three equivalent hydrogen atoms in ZnO (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-10-13
    Description: Author(s): F. Herklotz, A. Hupfer, K. M. Johansen, B. G. Svensson, S. G. Koch, and E. V. Lavrov A hydrogen-related defect in ZnO which causes two broad IR absorption bands at 3303 and 3321   cm − 1 is studied by means of infrared absorption spectroscopy and first-principles theory. In deuterated samples, the defect reveals two sharp absorption lines at 2466 and 2488   cm − 1 accompanied by weaker side… [Phys. Rev. B 92, 155203] Published Fri Oct 09, 2015
    Keywords: Semiconductors I: bulk
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    Physical activity in adulthood: genes and mortality (2015)
    Springer Nature
    Details
    Publication Date: 2015-12-16
    Description: Physical activity in adulthood: genes and mortality Scientific Reports, Published online: 15 December 2015; doi:10.1038/srep18259
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 4
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    Correlation of in Situ Oxazolidine Formation with Highly Synergistic Cytotoxicity and DNA Cross-Linking in Cancer Cells from Combinations of Doxorubicin and Formaldehyde (2016)
    American Chemical Society (ACS)
    Details
    Publication Date: 2016-02-27
    Description: Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b01956
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 5
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    An inefficient dwarf: chemical abundances and the evolution of the Ursa Minor dwarf spheroidal galaxy (2015)
    Oxford University Press
    Details
    Publication Date: 2015-03-21
    Description: We present detailed chemical element abundance ratios of 17 elements with eight ≤  Z  ≤ 60 in three metal-poor stars in the Ursa Minor dwarf spheroidal galaxy, which we combine with extant data from the literature to assess the predictions of a novel suite of galaxy chemical evolution models. The spectroscopic data were obtained with the Keck/High-Resolution Echelle Spectrograph instrument and revealed low metallicities of [Fe/H] = –2.12, –2.13 and –2.67 dex. While the most metal-poor star in our sample shows an overabundance of [Mn/Fe] and other Fe-peak elements, our overall findings are in agreement with previous studies of this galaxy: elevated values of the [α/Fe] ratios that are similar to, or only slightly lower than, the halo values but with SN Ia enrichment at very low metallicity, as well as an enhancement of the ratio of first to second peak neutron capture elements [Y/Ba] with decreasing metallicity. The chemical evolution models which were tailored to reproduce the metallicity distribution function of the dwarf spheroidal, indicate that Ursa Minor had an extended star formation which lasted nearly 5 Gyr with low efficiency and are able to explain the [Y/Ba] enhancement at low metallicity for the first time. In particular, we show that the present-day lack of gas is probably due to continuous loss of gas from the system, which we model as winds.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 6
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    Hydrogen centers and the conductivity of In_{2}O_{3} single crystals (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-02-25
    Description: Author(s): Weikai Yin, Kirby Smithe, Philip Weiser, Michael Stavola, W. Beall Fowler, Lynn Boatner, Stephen J. Pearton, David C. Hays, and Sandro G. Koch Transparent conducting oxides, such as In 2 O 3 , are optically transparent wide band gap semiconductors with high electrical conductivity and are used in applications such as transparent electrical circuits and flat panel displays. Some previous research has argued that conductivity in In 2 O 3 is caused mainly by oxygen vacancies, as in other transparent conducting oxides. Using infrared absorbtion spectroscopy on single-crystal In 2 O 3 , the authors show that, consistent with theory, interstital hydrogen forms shallow donors, which make an important contribution to the n -type conductivity. [Phys. Rev. B 91, 075208] Published Tue Feb 24, 2015
    Keywords: Semiconductors I: bulk
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 7
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    Interplay between interstitial and substitutional hydrogen donors in ZnO (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-06-19
    Description: Author(s): S. G. Koch, E. V. Lavrov, and J. Weber A Raman study on hydrogen donors in ZnO reveals the properties of bond-centered hydrogen (HBC) and hydrogen trapped in the oxygen vacancy (HO). The donors are identified by their electronic 1s→2s(2p) transitions and their characteristic local vibrational modes. The HO donor was detected preferential... [Phys. Rev. B 89, 235203] Published Wed Jun 18, 2014
    Keywords: Semiconductors I: bulk
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 8
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    Towards understanding the hydrogen molecule in ZnO (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-11-18
    Description: Author(s): S. G. Koch, E. V. Lavrov, and J. Weber Using Raman scattering, molecular hydrogen defects are shown to exist in ZnO, the first II-VI semiconductor in which this has been observed. The rotational-vibrational properties of the defects are shown to depend on the history of the sample and an ortho-para conversion between the nuclear spin states is observed. [Phys. Rev. B 90, 205212] Published Mon Nov 17, 2014
    Keywords: Semiconductors I: bulk
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 9
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    Kepler-47: a transiting circumbinary multiplanet system (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-08-31
    Description: We report the detection of Kepler-47, a system consisting of two planets orbiting around an eclipsing pair of stars. The inner and outer planets have radii 3.0 and 4.6 times that of Earth, respectively. The binary star consists of a Sun-like star and a companion roughly one-third its size, orbiting each other every 7.45 days. With an orbital period of 49.5 days, 18 transits of the inner planet have been observed, allowing a detailed characterization of its orbit and those of the stars. The outer planet's orbital period is 303.2 days, and although the planet is not Earth-like, it resides within the classical "habitable zone," where liquid water could exist on an Earth-like planet. With its two known planets, Kepler-47 establishes that close binary stars can host complete planetary systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Orosz, Jerome A -- Welsh, William F -- Carter, Joshua A -- Fabrycky, Daniel C -- Cochran, William D -- Endl, Michael -- Ford, Eric B -- Haghighipour, Nader -- MacQueen, Phillip J -- Mazeh, Tsevi -- Sanchis-Ojeda, Roberto -- Short, Donald R -- Torres, Guillermo -- Agol, Eric -- Buchhave, Lars A -- Doyle, Laurance R -- Isaacson, Howard -- Lissauer, Jack J -- Marcy, Geoffrey W -- Shporer, Avi -- Windmiller, Gur -- Barclay, Thomas -- Boss, Alan P -- Clarke, Bruce D -- Fortney, Jonathan -- Geary, John C -- Holman, Matthew J -- Huber, Daniel -- Jenkins, Jon M -- Kinemuchi, Karen -- Kruse, Ethan -- Ragozzine, Darin -- Sasselov, Dimitar -- Still, Martin -- Tenenbaum, Peter -- Uddin, Kamal -- Winn, Joshua N -- Koch, David G -- Borucki, William J -- New York, N.Y. -- Science. 2012 Sep 21;337(6101):1511-4. Epub 2012 Aug 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Astronomy Department, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USA. orosz@sciences.sdsu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22933522" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Cardiovascular risk factors emerge after artificial selection for low aerobic capacity (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-01-22
    Description: In humans, the strong statistical association between fitness and survival suggests a link between impaired oxygen metabolism and disease. We hypothesized that artificial selection of rats based on low and high intrinsic exercise capacity would yield models that also contrast for disease risk. After 11 generations, rats with low aerobic capacity scored high on cardiovascular risk factors that constitute the metabolic syndrome. The decrease in aerobic capacity was associated with decreases in the amounts of transcription factors required for mitochondrial biogenesis and in the amounts of oxidative enzymes in skeletal muscle. Impairment of mitochondrial function may link reduced fitness to cardiovascular and metabolic disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wisloff, Ulrik -- Najjar, Sonia M -- Ellingsen, Oyvind -- Haram, Per Magnus -- Swoap, Steven -- Al-Share, Qusai -- Fernstrom, Mats -- Rezaei, Khadijeh -- Lee, Sang Jun -- Koch, Lauren Gerard -- Britton, Steven L -- DK 54254/DK/NIDDK NIH HHS/ -- DK 57497/DK/NIDDK NIH HHS/ -- HL 64270/HL/NHLBI NIH HHS/ -- RR 17718/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2005 Jan 21;307(5708):418-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Olav Kyrres gt. 3, 7489 Trondheim, Norway. ulrik.wisloff@medisin.ntnu.no〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15662013" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue ; Aerobiosis ; Aging ; Animals ; Blood Pressure ; Body Weight ; Breeding ; Cardiovascular Diseases/*etiology/physiopathology ; Disease Models, Animal ; Endothelium, Vascular/physiology ; Exercise ; *Exercise Tolerance ; Female ; Glucose Tolerance Test ; Humans ; Hypertension/etiology/physiopathology ; Insulin/blood ; Insulin Resistance ; Lipids/blood ; Male ; Metabolic Syndrome X/etiology/physiopathology ; Mitochondria, Muscle/metabolism/*physiology ; Muscle, Skeletal/enzymology/metabolism ; Oxidation-Reduction ; Oxygen Consumption ; PPAR gamma/metabolism ; Physical Conditioning, Animal ; *Physical Exertion ; Rats ; Risk Factors ; Running ; Selection, Genetic ; Trans-Activators/metabolism ; Ventricular Function, Left
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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