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  • 1
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    Dihydroartemisinin attenuates lipopolysaccharide-induced osteoclastogenesis and bone loss via the mitochondria-dependent apoptosis pathway (2016)
    Springer Nature
    Details
    Publication Date: 2016-04-01
    Description: Dihydroartemisinin attenuates lipopolysaccharide-induced osteoclastogenesis and bone loss via the mitochondria-dependent apoptosis pathway Cell Death and Disease 7, e2162 (March 2016). doi:10.1038/cddis.2016.69 Authors: C Dou, N Ding, J Xing, C Zhao, F Kang, T Hou, H Quan, Y Chen, Q Dai, F Luo, J Xu & S Dong
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 2
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    Endoplasmic Reticulum Stress-Related Genes in Yellow Catfish Pelteobagrus fulvidraco: Molecular Characterization, Tissue Expression, and Expression Responses to Dietary Copper Deficiency and Excess (2015)
    Genetics Society of America (GSA)
    Details
    Publication Date: 2015-10-06
    Description: Two endoplasmic reticulum (ER) molecular chaperones [glucose-regulated protein 78 ( grp78 ) and calreticulin ( crt )] and three ER stress sensors [PKR-like ER kinase ( perk ), inositol requiring enzyme ( ire )-1α, and activating transcription factor ( atf )-6α] cDNAs were first characterized from yellow catfish, Pelteobagrus fulvidraco . The predicted amino acid sequences for the yellow catfish grp78 , crt , perk , ire -1α, and atf -6α revealed that the proteins contained all of the structural features that were characteristic of the five genes in other species, including the KDEL motif, signal peptide, sensor domain, and effector domain. mRNAs of the five genes mentioned above were expressed in various tissues, but their mRNA levels varied among tissues. Dietary Cu excess, but not Cu deficiency, activated the chaperones ( grp78 and crt ) and folding sensors in ER, and the UPR signaling pathways ( i.e. , perk – eif 2α and the ire 1– xbp1 ) in a tissue-specific manner. For the first time, our study cloned grp78 , crt , perk , ire -1α, and atf -6α genes in yellow catfish and demonstrated their differential expression among tissues. Moreover, the present study also indicated differential regulation of these ER stress–related genes by dietary Cu deficiency and excess, which will be beneficial for us to evaluate effects of dietary Cu levels in fish at the molecular level, based on the upstream pathway of lipid metabolism (the ER) and thus provide novel insights regarding the nutrition of Cu in fish.
    Electronic ISSN: 2160-1836
    Topics: Biology
    Published by Genetics Society of America (GSA)
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  • 3
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    Substrate polarization effects in two-dimensional magnetic arrays (2012)
    American Physical Society (APS)
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    Publication Date: 2012-08-16
    Description: Author(s): N. Mikuszeit, F. Luo, G. Gómez-Santos, J. Camarero, and R. Miranda The magnetostatic energy of a two-dimensional (2D) periodic array of magnetic particles (or a thin film with periodic magnetization) is evaluated, including additional energy terms due to a polarizable substrate. The polarization of the substrate is solved self-consistently using surface charges. Th... [Phys. Rev. B 86, 054423] Published Wed Aug 15, 2012
    Keywords: Magnetism
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    DeOri: a database of eukaryotic DNA replication origins (2012)
    Oxford University Press
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    Publication Date: 2012-05-22
    Description: : DNA replication, a central event for cell proliferation, is the basis of biological inheritance. The identification of replication origins helps to reveal the mechanism of the regulation of DNA replication. However, only few eukaryotic replication origins were characterized not long ago; nevertheless, recent genome-wide approaches have boosted the number of mapped replication origins. To gain a comprehensive understanding of the nature of eukaryotic replication origins, we have constructed a Database of Eukaryotic ORIs (DeOri), which contains all the eukaryotic ones identified by genome-wide analyses currently available. A total of 16 145 eukaryotic replication origins have been collected from 6 eukaryotic organisms in which genome-wide studies have been performed, the replication-origin numbers being 433, 7489, 1543, 148, 348 and 6184 for humans, mice, Arabidopsis thaliana , Kluyveromyces lactis , Schizosaccharomyces pombe and Drosophila melanogaster , respectively. Availability: Database of Eukaryotic ORIs (DeOri) can be accessed from http://tubic.tju.edu.cn/deori/ Contact: ctzhang@tju.edu.cn
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 5
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    Adaptive Bees Algorithm--Bioinspiration from Honeybee Foraging to Optimize Fuel Economy of a Semi-Track Air-Cushion Vehicle (2011)
    Oxford University Press
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    Publication Date: 2011-11-24
    Description: This interdisciplinary study covers bionics, optimization and vehicle engineering. Semi-track air-cushion vehicle (STACV) provides a solution to transportation on soft terrain, whereas it also brings a new problem of excessive fuel consumption. By mimicking the foraging behaviour of honeybees, the bioinspired adaptive bees algorithm (ABA) is proposed to calculate its running parameters for fuel economy optimization. Inherited from the basic algorithm prototype, it involves parallel-operated global search and local search, which undertake exploration and exploitation, respectively. The innovation of this improved algorithm lies in the adaptive adjustment mechanism of the range of local search (called ‘patch size’) according to the source and the rate of change of the current optimum. Three gradually in-depth experiments are implemented for 143 kinds of soils. First, the two optimal STACV running parameters present the same increasing or decreasing trend with soil parameters. This result is consistent with the terramechanics-based theoretical analysis. Second, the comparisons with four alternative algorithms exhibit the ABA's effectiveness and efficiency, and accordingly highlight the advantage of the novel adaptive patch size adjustment mechanism. Third, the impacts of two selected optimizer parameters to optimization accuracy and efficiency are investigated and their recommended values are thus proposed.
    Print ISSN: 0010-4620
    Electronic ISSN: 1460-2067
    Topics: Computer Science
    Published by Oxford University Press
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  • 6
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    FaSD-somatic: a fast and accurate somatic SNV detection algorithm for cancer genome sequencing data (2014)
    Oxford University Press
    Details
    Publication Date: 2014-08-27
    Description: : Recent advances in high-throughput sequencing technologies have enabled us to sequence large number of cancer samples to reveal novel insights into oncogenetic mechanisms. However, the presence of intratumoral heterogeneity, normal cell contamination and insufficient sequencing depth, together pose a challenge for detecting somatic mutations. Here we propose a fast and an accurate somatic single-nucleotide variations (SNVs) detection program, FaSD-somatic. The performance of FaSD-somatic is extensively assessed on various types of cancer against several state-of-the-art somatic SNV detection programs. Benchmarked by somatic SNVs from either existing databases or de novo higher-depth sequencing data, FaSD-somatic has the best overall performance. Furthermore, FaSD-somatic is efficient, it finishes somatic SNV calling within 14 h on 50X whole genome sequencing data in paired samples. Availability and implementation: The program, datasets and supplementary files are available at http://jjwanglab.org/FaSD-somatic/ . Contact: wangdatou2009@gmail.com . Supplementary information: Supplementary data are available at Bioinformatics online
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 7
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    Prenatal diagnosis of aneuploidies [Medical Sciences] (2014)
    National Academy of Sciences
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    Publication Date: 2014-05-21
    Description: Massively parallel sequencing (MPS) of cell-free fetal DNA from maternal plasma has revolutionized our ability to perform noninvasive prenatal diagnosis. This approach avoids the risk of fetal loss associated with more invasive diagnostic procedures. The present study developed an effective method for noninvasive prenatal diagnosis of common chromosomal aneuploidies using...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 8
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    Genome editing eradicates HIV-1 [Medical Sciences] (2014)
    National Academy of Sciences
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    Publication Date: 2014-08-06
    Description: AIDS remains incurable due to the permanent integration of HIV-1 into the host genome, imparting risk of viral reactivation even after antiretroviral therapy. New strategies are needed to ablate the viral genome from latently infected cells, because current methods are too inefficient and prone to adverse off-target effects. To eliminate...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 9
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    Actin-propelled invasive membrane protrusions promote fusogenic protein engagement during cell-cell fusion (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-09
    Description: Cell-cell fusion is critical for the conception, development, and physiology of multicellular organisms. Although cellular fusogenic proteins and the actin cytoskeleton are implicated in cell-cell fusion, it remains unclear whether and how they coordinate to promote plasma membrane fusion. We reconstituted a high-efficiency, inducible cell fusion culture system in the normally nonfusing Drosophila S2R+ cells. Both fusogenic proteins and actin cytoskeletal rearrangements were necessary for cell fusion, and in combination they were sufficient to impart fusion competence. Localized actin polymerization triggered by specific cell-cell or cell-matrix adhesion molecules propelled invasive cell membrane protrusions, which in turn promoted fusogenic protein engagement and plasma membrane fusion. This de novo cell fusion culture system reveals a general role for actin-propelled invasive membrane protrusions in driving fusogenic protein engagement during cell-cell fusion.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631436/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631436/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shilagardi, Khurts -- Li, Shuo -- Luo, Fengbao -- Marikar, Faiz -- Duan, Rui -- Jin, Peng -- Kim, Ji Hoon -- Murnen, Katherine -- Chen, Elizabeth H -- R01 GM098816/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2013 Apr 19;340(6130):359-63. doi: 10.1126/science.1234781. Epub 2013 Mar 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23470732" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/*metabolism ; Animals ; Caenorhabditis elegans Proteins/genetics/*metabolism ; Cell Adhesion Molecules/genetics/*metabolism ; *Cell Communication ; Cell Culture Techniques ; *Cell Fusion ; Cell Line ; Cell Surface Extensions/metabolism/physiology ; Drosophila Proteins/genetics/metabolism ; Drosophila melanogaster/cytology ; Immunoglobulins/genetics/metabolism ; Membrane Glycoproteins/genetics/*metabolism ; Membrane Proteins/genetics/metabolism ; Muscle Proteins/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Comparing quantitative analysis on revealed comparative advantages of aquatic products trade of china and ASEAN based on 21st century maritime silk road (2017)
    Institute of Physics (IOP)
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    Publication Date: 2017-11-28
    Description: As the world’s leading aquaculture, aquatic production and trading country, China’s development of aquatic products trade with ASEAN is facing a historic opportunity in the favourable circumstances of construction of the 21st century Maritime Silk Road. In order to make guidance of the product selection and transformation for corresponding export enterprises, this article makes a quantitative analysis the Revealed Comparative Advantage of aquatic products trade from China and ASEAN respectively based on the HS classification and thoroughly compares the RCA indices. The comparison results show that the international competitiveness of aquatic products structures of China and ASEAN are quite different with few overlaps of strong competitive products, and there is a great gap between the two areas in many kinds of products.
    Print ISSN: 1755-1307
    Electronic ISSN: 1755-1315
    Topics: Geography , Geosciences , Physics
    Published by Institute of Physics (IOP)
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