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  • 1
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    Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-07-29
    Description: Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the two most common non-Hodgkin lymphomas (NHLs). Here we sequenced tumour and matched normal DNA from 13 DLBCL cases and one FL case to identify genes with mutations in B-cell NHL. We analysed RNA-seq data from these and another 113 NHLs to identify genes with candidate mutations, and then re-sequenced tumour and matched normal DNA from these cases to confirm 109 genes with multiple somatic mutations. Genes with roles in histone modification were frequent targets of somatic mutation. For example, 32% of DLBCL and 89% of FL cases had somatic mutations in MLL2, which encodes a histone methyltransferase, and 11.4% and 13.4% of DLBCL and FL cases, respectively, had mutations in MEF2B, a calcium-regulated gene that cooperates with CREBBP and EP300 in acetylating histones. Our analysis suggests a previously unappreciated disruption of chromatin biology in lymphomagenesis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210554/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210554/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morin, Ryan D -- Mendez-Lago, Maria -- Mungall, Andrew J -- Goya, Rodrigo -- Mungall, Karen L -- Corbett, Richard D -- Johnson, Nathalie A -- Severson, Tesa M -- Chiu, Readman -- Field, Matthew -- Jackman, Shaun -- Krzywinski, Martin -- Scott, David W -- Trinh, Diane L -- Tamura-Wells, Jessica -- Li, Sa -- Firme, Marlo R -- Rogic, Sanja -- Griffith, Malachi -- Chan, Susanna -- Yakovenko, Oleksandr -- Meyer, Irmtraud M -- Zhao, Eric Y -- Smailus, Duane -- Moksa, Michelle -- Chittaranjan, Suganthi -- Rimsza, Lisa -- Brooks-Wilson, Angela -- Spinelli, John J -- Ben-Neriah, Susana -- Meissner, Barbara -- Woolcock, Bruce -- Boyle, Merrill -- McDonald, Helen -- Tam, Angela -- Zhao, Yongjun -- Delaney, Allen -- Zeng, Thomas -- Tse, Kane -- Butterfield, Yaron -- Birol, Inanc -- Holt, Rob -- Schein, Jacqueline -- Horsman, Douglas E -- Moore, Richard -- Jones, Steven J M -- Connors, Joseph M -- Hirst, Martin -- Gascoyne, Randy D -- Marra, Marco A -- 1U01CA114778/CA/NCI NIH HHS/ -- HHSN261200800001E/PHS HHS/ -- P50CA130805-01/CA/NCI NIH HHS/ -- TGT-53912/Canadian Institutes of Health Research/Canada -- U24 CA143866/CA/NCI NIH HHS/ -- U24 CA143866-01/CA/NCI NIH HHS/ -- U24 CA143866-02/CA/NCI NIH HHS/ -- U24 CA143866-03/CA/NCI NIH HHS/ -- England -- Nature. 2011 Jul 27;476(7360):298-303. doi: 10.1038/nature10351.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21796119" target="_blank"〉PubMed〈/a〉
    Keywords: Chromatin/genetics/metabolism ; DNA-Binding Proteins/genetics/metabolism ; Genome, Human/genetics ; Histone Acetyltransferases/genetics/metabolism ; Histone-Lysine N-Methyltransferase/genetics/metabolism ; Histones/*metabolism ; Humans ; Loss of Heterozygosity/genetics ; Lymphoma, Follicular/enzymology/genetics ; Lymphoma, Large B-Cell, Diffuse/enzymology/genetics ; Lymphoma, Non-Hodgkin/enzymology/*genetics ; MADS Domain Proteins/genetics/metabolism ; MEF2 Transcription Factors ; Mutation/*genetics ; Myogenic Regulatory Factors/genetics/metabolism ; Neoplasm Proteins/genetics/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Sapphire substrate-induced effects in VO2 thin films grown by oxygen plasma-assisted pulsed laser deposition (2015)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2015-11-19
    Description: We investigate the structural and electronic properties of VO 2 thin films on c-plane sapphire substrates with three different surface morphologies to control the strain at the substrate-film interface. Only non-annealed substrates with no discernible surface features (terraces) provided a suitable template for VO 2 film growth with a semiconductor-metal transition (SMT), which was much lower than the bulk transition temperature. In addition to strain, oxygen vacancy concentration also affects the properties of VO 2 , which can be controlled through deposition conditions. Oxygen plasma-assisted pulsed laser deposition allows favorable conditions for VO 2 film growth with SMTs that can be easily tailored for device applications.
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
    Published by American Institute of Physics (AIP)
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  • 3
    Electronic Resource
    Electronic Resource
    Microstructural control of NdFeB cast ingots for achieving 50 MGOe sintered magnets : The 40th annual conference on magnetism and magnetic materials (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 4830-4832 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The combination of chemical composition and microstructure of cast alloy has been found to be critical to the performance of NdFeB sintered magnets. Maximizing the amount of Nd2Fe14B phase (or minimizing the amount of secondary phase) by reducing the Nd content more closely to the stoichiometric composition appears to be essential for obtaining high BHmax magnets. However, α-Fe precipitation has been found to increase with decreasing Nd content and severely hinders the development of high BHmax magnets. A two-step method, incorporating ingot casting and isothermal annealing, has been developed to minimize the amount of precipitated α-Fe in low Nd content alloys. This method provides a drastic improvement in the Br and BHmax of sintered magnets obtained. By decreasing the Nd content to 13 at. % in the cast alloy, incorporating better particle control during fine milling, and controlling grain growth during sintering; magnets with a Br of more than 14.5 kG and a BHmax of 50 MGOe have been consistently obtained. Furthermore, because of the reduction in the amount of Nd-rich grain boundary phase, a significant improvement in the corrosion resistance of magnets was also observed. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.361622
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  • 4
    Electronic Resource
    Electronic Resource
    The effects of average grain size on the magnetic properties and corrosion resistance of NdFeB sintered magnets : The 40th annual conference on magnetism and magnetic materials (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 5501-5503 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Magnets with a nominal composition of Nd14.5Fe79.5B6 have been prepared by the conventional powder metallurgy technique. Precursor alloy powders with average particle sizes of 2.5, 3.0, 3.5, and 4.2 μm were included in this study. Average particle size and oxygen content were effectively manipulated to control the average grain size in the sintered magnets. Typically, for NdFeB sintered magnets, the corrosion resistance of these magnets was improved with increasing oxygen content. The corrosion resistance of magnets varied significantly with the average particle size of precursor alloy powders. For a fixed oxygen content, magnets made from powders of larger sizes exhibited a higher weight loss (a poor corrosion resistance) when compared to those made from smaller alloy powders. However, the Hci of magnets made from 2.5, 3.0, and 3.5 μm precursor alloy powders was found to decrease drastically with increasing oxygen content while magnets made from the 4.2 μm powder was found to remain relatively constant with increasing oxygen content. To optimize magnetic performance, one needs to compromise the corrosion resistance and the Hci obtained by balancing the average particle size of the precursor alloy powder for magnet fabrication, as well as the oxygen content and the average grain size in the finished magnet. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.362291
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of Fe and/or Cu contents on the intrinsic coercivity of Sm2Co17-type coercive powders for the bonded magnet application : The 40th annual conference on magnetism and magnetic materials (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 6335-6337 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The microstructure of conventionally cast Sm(CobalFe0.28CuvZr0.022)8.0 alloys, where v=0.043–0.092, were examined by optical microscopy and scanning electron microscope with energy dispersed analytical x ray in the as-cast state. In addition to the regular 2:17 matrix phase, the Sm-rich grain boundary phase and the needle-like Zr-rich phases are present in most commercial Sm(Co,Fe,Cu,Zr)z alloys. A grayish Sm- and Cu-rich grain boundary phase was found in alloys with v≥0.07. Attention was focused on the impact of increasing Cu content to the microstructure and process parameters required to produce coercive powder for bonded magnets. An increase of the Cu content from the v value from 0.043 to 0.092 shifts the liquid+2:17→TbCu7-type transformation temperature from slightly above 1180 to approximately 1140 °C. The Hci of optimally prepared magnet was found to increase significantly while the Br remained relative constant when the Cu content is increased. When the Cu content was increased to beyond v=0.07, a slight decrease in the BHmax was noticed. A magnetizing field of 15 kOe and more than 50 kOe were determined to be necessary to charge magnets with a Hci of 12 and 25 kOe, respectively, to about 90% of their full potential. For a composition of Sm(CobalFeuCu0.07Zr0.022)8.0, a slight increase in Fe concentration from u=0.22 to 0.28 was found to increase the Br of an optimally prepared magnet from 8.07 to 8.28 kG and decrease the Hci from 11.8 to 9.7 kOe. A BHmax of 15 MGOe was obtained on a bonded magnet with a composition of Sm(CobalFe0.28Cu0.07Zr0.022)8.0 when the data are normalized to a specific density of 7.0 g/cm3. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.361990
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  • 6
    Electronic Resource
    Electronic Resource
    Comparison of the improvement of thermal stability of NdFeB sintered magnets: Intrinsic and/or microstructural : 38th Annual Conference on Magnetism and Magnetic Materials (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 75 (1994), S. 6628-6630 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Temperature-dependent magnetic properties of nine NdFeB sintered magnets with various Co-Nb, Co-V, or Co-Mo additions have been measured up to 175 °C using both closed-loop and open-circuit methods. The irreversible loss of induction, reversible temperature coefficient of induction (α), and temperature coefficient of intrinsic coercivity β have been related to the Tc, the Br, and the Hci at 25 and 175 °C. The irreversible loss of induction is strongly affected by the Hci at 25 °C and the α has been found to be strongly dependent upon the Tc. Intrinsic coercivity of more than 25 and 7.5 kOe at 25 and 175 °C, respectively, are essential to bring the β to better than −0.5%/ °C. A magnet with a composition of Nd12Dy3Fe70Co5Nb2B8 has been found to exhibit an outstanding thermal stability: a Br of 8.5 kG (comparable to that of SmCo5 sintered magnet) and a Hci of 12.9 kOe when measured at 175 °C. An α of −0.10%/ °C and a β of −0.4%/ °C have been obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.356876
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  • 7
    Electronic Resource
    Electronic Resource
    Thermodynamic Properties of Thiophene1 (1949)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 71 (1949), S. 797-808 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01171a010
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  • 8
    Electronic Resource
    Electronic Resource
    Hydrazine: Heat Capacity, Heats of Fusion and Vaporization, Vapor Pressure, Entropy and Thermodynamic Functions1 (1949)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 71 (1949), S. 2293-2297 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01175a007
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  • 9
    Electronic Resource
    Electronic Resource
    Isomerization Equilibria. The C2H6S, C3H8S, and C4H10S Alkane Thiols and Sulfides and the Methylthiophenes. (1959)
    s.l. : American Chemical Society
    Journal of chemical & engineering data 4 (1959), S. 246-251 
    Details
    ISSN: 1520-5134
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/je60003a014
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  • 10
    Electronic Resource
    Electronic Resource
    Thermodynamic Properties, Vibrational Assignment and Rotational Conformations of 2-Methyl-1-butene (1959)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 81 (1959), S. 1331-1334 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01515a017
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