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  • 1
    Electronic Resource
    Electronic Resource
    HL-A8 AND THE IMMUNE RESPONSE TO VARIOUS ANTIGENS (1976)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 3 (1976), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The possession of the histocompatibility antigen HL-A8 has been correlated with serum levels of antibodies to gluten and a variety of other dietary, viral, and bacterial antigens and autoantigens. The only significant correlation with HL-A8 was of raised levels of gluten antibody. Thus it seems that HL-A8 may be associated with an enhanced immune response specifically to gluten, and not with a generally enhanced immunological responsiveness as has been suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1976.tb00571.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of captopril on skin blood flow following intradermal bradykinin measured by laser Doppler flowmetry (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 471-475 
    Details
    ISSN: 1432-1041
    Keywords: bradykinin ; captopril ; laser Doppler flowmetry ; weal ; flare ; skin blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of captopril on skin response to intradermal injection of bradykinin was investigated by laser Doppler flowmetry (LDF) and weal and flare measurements in this randomised, double-blind, placebo-controlled, cross-over balanced study. Intradermal injections of 1 and 2.5 µg of bradykinin and normal saline were made into the forearm skin of six healthy volunteers between 1 and 2 h (t1) and between 3 and 4 h (t2) after either 25 mg captopril or placebo. Skin blood flow outside the induced weal was monitored continuously by LDF for 15 min and the mean LDF values over the last 15 s were used for analysis. Weal and flare sizes were measured at 15 min. On the placebo days, the mean LDF output, weal volume and flare area increased with incremental bradykinin dose. Pre-treatment with captopril significantly increased LDF output following intradermal bradykinin at t1 but not at t2. At both t1 and t2, captopril significantly increased weal volume. There was no significant difference between treatments in flare areas. Skin response following intradermal normal saline, measured by the above parameters, was not affected by captopril. This study showed that captopril potentiated the effects of intradermal bradykinin both with respect to blood flow changes and weal formation. The non-invasive technique of LDF can be used to detect the skin blood flow changes induced by intradermal bradykinin and the potentiation of this effect by captopril. It appears to be a useful and more objective method of quantifying local cutaneous blood flow changes than measurement of flare area.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558126
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  • 3
    Electronic Resource
    Electronic Resource
    A double blind trial of UK-38,485, an orally active thromboxane synthetase inhibitor, in the treatment of Raynaud's syndrome (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 61-65 
    Details
    ISSN: 1432-1041
    Keywords: thromboxane synthetase inhibitors ; Raynaud's syndrome ; systemic sclerosis ; UK-38,485 ; ischaemic attacks ; red blood cell rheology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Ten patients with moderate to severe Raynaud's syndrome were recruited into a four week randomised double blind crossover study to compare the efficacy of UK-38,485 50 mg, a new thromboxane synthetase inhibitor with that of placebo. With the doses used there was no significant difference between the two treatment periods in the number, severity and duration of ischaemic attacks, the mean hand temperatures, forearm and digital blood flow and red blood cell rheology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553156
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  • 4
    Electronic Resource
    Electronic Resource
    A double blind trial of UK-38,485, an orally active thromboxane synthetase inhibitor, in the treatment of Raynaud’s syndrome (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 61-65 
    Details
    ISSN: 1432-1041
    Keywords: thromboxane synthetase inhibitors ; Raynaud’s syndrome ; systemic sclerosis ; UK-38,485 ; ischaemic attacks ; red blood cell rheology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Ten patients with moderate to severe Raynaud’s syndrome were recruited into a four week randomised double blind crossover study to compare the efficacy of UK-38,485 50 mg, a new thromboxane synthetase inhibitor with that of placebo. With the doses used there was no significant difference between the two treatment periods in the number, severity and duration of ischaemic attacks, the mean hand temperatures, forearm and digital blood flow and red blood cell rheology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02395208
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  • 5
    Electronic Resource
    Electronic Resource
    Cold sensitivity in essential hypertension: the effect of beta- and combined alpha- and beta-blockade (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 33-36 
    Details
    ISSN: 1432-1041
    Keywords: cold sensitivity ; hypertension ; alpha- and beta-blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The presence of cold sensitivity was investigated in three groups of patients; untreated hypertensives and hypertensives treated by a beta-adrenoceptor blocker (propranolol) or by a combined alpha-and beta-adrenoceptor blocker (labetalol) at two ambient temperatures. At a comfortable ambient (24°C) one-third of the untreated and those treated with beta-blockade only showed cold sensitivity as compared with 16% of patients on the combined therapy. Under conditions of mild cold stress (20°C) cold sensitivity increased in frequency in all three groups, more than half of the untreated and beta-blocked patients were affected and greater than one-third of those with alpha- and beta-blockade. These findings indicate that in the general population of hypertensives treatment with beta-adrenoceptor blockade alone may have little effect on the peripheral vasculature and that a useful degree of protection may be provided by therapy which blocks both receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547365
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  • 6
    Electronic Resource
    Electronic Resource
    Cutaneous blood flow changes and weal induced by intradermal bradykinin following pretreatment with indomethacin and captopril (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 41-45 
    Details
    ISSN: 1432-1041
    Keywords: Bradykinin ; Captopril ; Indomethacin ; laser Doppler ; cutaneous blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of indomethacin and captopril on local cutaneous blood flow changes and weal induced by intradermal injections of bradykinin were assessed in two randomised, double-blind, placebo-controlled studies in healthy volunteers. Alterations in cutaneous blood flow were estimated by laser Doppler flowmetry (LDF) and erythema area. LDF output, erythema area and weal volume increased with incremental bradykinin dose. Single doses of indomethacin 25 mg and 75 mg did not affect these cutaneous responses compared with placebo. Captopril 25 mg significantly potentiated the increase in local cutaneous blood flow measured by LDF, but not erythema area, and weal volume induced by bradykinin. The effects of the combined treatment of indomethacin 75 mg and captopril 25 mg were not significantly different from those due to captopril alone. The enhanced cutaneous effects of bradykinin following administration of captopril are in keeping with effective kininase II inhibition in the tissues. Cyclo-oxygenase products release does not appear to contribute to the cutaneous actions of bradykinin nor the potentiation of these responses by captopril.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315278
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  • 7
    Electronic Resource
    Electronic Resource
    Numerical model of deep venous thrombosis detection using venous occlusion strain gauge plethysmography (2000)
    Springer
    Medical & biological engineering & computing 38 (2000), S. 348-355 
    Details
    ISSN: 1741-0444
    Keywords: Deep venous thrombosis ; Venous occlusion plethysmography ; Limb blood flow ; Theoretical model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Strain gauge plethysmography (SGP) is a non-invasive method used in the detection of deep venous thrombosis (DVT). The technique is based on the measurement of calf volume changes in response to venous occlusion by a thigh cuff, the volume changes reflecting the rates of arterial inflow and venous outflow. A numerical model of the blood circulation within the limb and the response of this to a SGP test has been derived, based on treating the different parts of the circulatory system in the leg as resistance and capacitance elements. The simulation results were compared with clinical studies and support the ability of SGP to detect non-occlusive clots of more than 50–60% of the lumen, as well detecting calf vein pressure appears to be a particularly important factor within the model. In addition, increases in venous tone due to post-operative venospasm were shown to be a potential source of false positive results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02347057
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  • 8
    Electronic Resource
    Electronic Resource
    The manufacture of high performance composite propellants and novel charges by Batch and Continuous Extrusion Processes (1990)
    Weinheim : Wiley-Blackwell
    Propellants, Explosives, Pyrotechnics 15 (1990), S. 235-242 
    Details
    ISSN: 0721-3115
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Recent developments in extrudable composite propellant technology enable higher energy/density formulations and novel charges to be successfully manufactured, which cannot be produced by castable composite technology processes. These also offer substantial capital, labour and time savings in certain production applications.New heavy duty processing machines have been developed recently, which have been used successfully for the safe and efficient manufacture of new high energy/fast burning rate composite propellants, using batch and continuous processes. These include injection flow forming techniques and die extrusion processes for filling rocket motors. A range of non-energetic binder systems based on non-curing plastic, curing HTPB and TPE binder systems have been successfully manufactured.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prep.19900150602
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  • 9
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    Supernova 2014J at M82 - II. Direct analysis of a middle-class Type Ia supernova (2016)
    Oxford University Press
    Details
    Publication Date: 2016-06-04
    Description: We analyse a time series of optical spectra of SN 2014J from almost two weeks prior to maximum to nearly four months after maximum. We perform our analysis using the synow code, which is well suited to track the distribution of the ions with velocity in the ejecta. We show that almost all of the spectral features during the entire epoch can be identified with permitted transitions of the common ions found in normal supernovae (SNe) Ia in agreement with previous studies. We show that 2014J is a relatively normal SN Ia. At early times the spectral features are dominated by Si  ii , S  ii , Mg  ii , and Ca  ii . These ions persist to maximum light with the appearance of Na  i and Mg  i . At later times iron-group elements also appear, as expected in the stratified abundance model of the formation of normal Type Ia SNe. We do not find significant spectroscopic evidence for oxygen, until 100 d after maximum light. The +100 d identification of oxygen is tentative, and would imply significant mixing of unburned or only slight processed elements down to a velocity of 6000 kms –1 . Our results are in relatively good agreement with other analyses in the infrared. We briefly compare SN 2011fe to SN 2014J and conclude that the differences could be due to different central densities at ignition or differences in the C/O ratio of the progenitors.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 10
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    SN 2014J at M82 - I. A middle-class Type Ia supernova by all spectroscopic metrics (2016)
    Oxford University Press
    Details
    Publication Date: 2016-01-22
    Description: We present the intensive spectroscopic follow up of the Type Ia supernova (SN Ia) 2014J in the starburst galaxy M82. Twenty-seven optical spectra have been acquired from 2014 January 22 to September 1 with the Isaac Newton and William Herschel Telescopes. After correcting the observations for the recession velocity of M82 and for Milky Way and host galaxy extinction, we measured expansion velocities from spectral line blueshifts and pseudo-equivalent width of the strongest features in the spectra, which gives an idea on how elements are distributed within the ejecta. We position SN 2014J in the Benetti, Branch et al. and Wang et al. diagrams. These diagrams are based on properties of the Si ii features and provide dynamical and chemical information about the SN ejecta. The nearby SN 2011fe, which showed little evidence for reddening in its host galaxy, is shown as a reference for comparisons. SN 2014J is a border-line object between the Core-normal and Broad-line groups, which corresponds to an intermediate position between low-velocity gradient and high-velocity gradient objects. SN 2014J follows the $R({\rm Si\,{\small {II}}})$ – m 15 correlation, which confirms its classification as a relatively normal SN Ia. Our description of the SN Ia in terms of the evolution of the pseudo-equivalent width of various ions as well as the position in the various diagrams put this specific SN Ia into the overall sample of SN Ia.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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