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  • 1
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    Wentilactone B induces G2/M phase arrest and apoptosis via the Ras/Raf/MAPK signaling pathway in human hepatoma SMMC-7721 cells (2013)
    Springer Nature
    Details
    Publication Date: 2013-06-07
    Description: Wentilactone B induces G2/M phase arrest and apoptosis via the Ras/Raf/MAPK signaling pathway in human hepatoma SMMC-7721 cells Cell Death and Disease 4, e657 (June 2013). doi:10.1038/cddis.2013.182 Authors: Z Zhang, L Miao, C Lv, H Sun, S Wei, B Wang, C Huang & B Jiao
    Keywords: Wentilactone BSMMC-7721 cellscell cycle arrestapoptosisMAPK pathway
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 2
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    Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway (2013)
    Springer Nature
    Details
    Publication Date: 2013-12-06
    Description: Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway Cell Death and Disease 4, e952 (December 2013). doi:10.1038/cddis.2013.484 Authors: C Lv, Y Hong, L Miao, C Li, G Xu, S Wei, B Wang, C Huang & B Jiao
    Keywords: Wentilactone Anovel antitumor agentlung cancerRas/Raf/ERK/p53-p21 pathway
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 3
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    Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-10-22
    Description: Two forms of X-chromosome inactivation (XCI) ensure the selective silencing of female sex chromosomes during mouse embryogenesis. Imprinted XCI begins with the detection of Xist RNA expression on the paternal X chromosome (Xp) at about the four-cell stage of embryonic development. In the embryonic tissues of the inner cell mass, a random form of XCI occurs in blastocysts that inactivates either Xp or the maternal X chromosome (Xm). Both forms of XCI require the non-coding Xist RNA that coats the inactive X chromosome from which it is expressed. Xist has crucial functions in the silencing of X-linked genes, including Rnf12 (refs 3, 4) encoding the ubiquitin ligase RLIM (RING finger LIM-domain-interacting protein). Here we show, by targeting a conditional knockout of Rnf12 to oocytes where RLIM accumulates to high levels, that the maternal transmission of the mutant X chromosome (Deltam) leads to lethality in female embryos as a result of defective imprinted XCI. We provide evidence that in Deltam female embryos the initial formation of Xist clouds and Xp silencing are inhibited. In contrast, embryonic stem cells lacking RLIM are able to form Xist clouds and silence at least some X-linked genes during random XCI. These results assign crucial functions to the maternal deposit of Rnf12/RLIM for the initiation of imprinted XCI.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967734/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967734/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shin, Jongdae -- Bossenz, Michael -- Chung, Young -- Ma, Hong -- Byron, Meg -- Taniguchi-Ishigaki, Naoko -- Zhu, Xiaochun -- Jiao, Baowei -- Hall, Lisa L -- Green, Michael R -- Jones, Stephen N -- Hermans-Borgmeyer, Irm -- Lawrence, Jeanne B -- Bach, Ingolf -- 5 P30 DK32520/DK/NIDDK NIH HHS/ -- DK32520/DK/NIDDK NIH HHS/ -- GM053234/GM/NIGMS NIH HHS/ -- R01 CA131158/CA/NCI NIH HHS/ -- R01 CA131158-04/CA/NCI NIH HHS/ -- R01 GM033977/GM/NIGMS NIH HHS/ -- R01 GM053234/GM/NIGMS NIH HHS/ -- R01CA131158/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Oct 21;467(7318):977-81. doi: 10.1038/nature09457.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS), Worcester, Massachusetts 01605, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20962847" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Congenic ; Blastocyst/metabolism ; Cell Line ; Chromosomes, Mammalian/*genetics ; Embryo Loss/genetics ; Fathers ; Female ; Gene Silencing ; *Genomic Imprinting ; Male ; Mice ; Mice, Transgenic ; *Mothers ; RNA, Long Noncoding ; RNA, Untranslated/genetics ; Repressor Proteins/deficiency/genetics/*metabolism ; Ubiquitin-Protein Ligases ; X Chromosome/*genetics ; X Chromosome Inactivation/*genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-05-30
    Description: In female mice, two forms of X-chromosome inactivation (XCI) ensure the selective silencing of female sex chromosomes during mouse embryogenesis. Beginning at the four-cell stage, imprinted XCI (iXCI) exclusively silences the paternal X chromosome. Later, around implantation, epiblast cells of the inner cell mass that give rise to the embryo reactivate the paternal X chromosome and undergo a random form of XCI (rXCI). Xist, a long non-coding RNA crucial for both forms of XCI, is activated by the ubiquitin ligase RLIM (also known as Rnf12). Although RLIM is required for triggering iXCI in mice, its importance for rXCI has been controversial. Here we show that RLIM levels are downregulated in embryonic cells undergoing rXCI. Using mouse genetics we demonstrate that female cells lacking RLIM from pre-implantation stages onwards show hallmarks of XCI, including Xist clouds and H3K27me3 foci, and have full embryogenic potential. These results provide evidence that RLIM is dispensable for rXCI, indicating that in mice an RLIM-independent mechanism activates Xist in the embryo proper.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105192/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105192/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shin, JongDae -- Wallingford, Mary C -- Gallant, Judith -- Marcho, Chelsea -- Jiao, Baowei -- Byron, Meg -- Bossenz, Michael -- Lawrence, Jeanne B -- Jones, Stephen N -- Mager, Jesse -- Bach, Ingolf -- CA077735/CA/NCI NIH HHS/ -- CA131158/CA/NCI NIH HHS/ -- DK32520/DK/NIDDK NIH HHS/ -- GM053234/GM/NIGMS NIH HHS/ -- R01 CA131158/CA/NCI NIH HHS/ -- R01 GM053234/GM/NIGMS NIH HHS/ -- England -- Nature. 2014 Jul 3;511(7507):86-9. doi: 10.1038/nature13286. Epub 2014 May 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS), Worcester, Massachusetts 01605, USA. ; Veterinary & Animal Sciences, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA. ; Department of Cell and Developmental Biology, UMMS, Worcester, Massachusetts 01605, USA. ; 1] Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS), Worcester, Massachusetts 01605, USA [2] Kunming Institute of Zoology, Chinese Academy of Science, Kunming 650223, China. ; Ortenau Klinikum Lahr-Ettenheim, Institut fur Pathologie, 77933 Lahr, Germany. ; 1] Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS), Worcester, Massachusetts 01605, USA [2] Program in Molecular Medicine, UMMS, Worcester, Massachusetts 01605, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24870238" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Down-Regulation ; Embryo Implantation ; Embryo, Mammalian/embryology/metabolism ; Female ; Germ Layers/*embryology/*metabolism ; Histones/chemistry/metabolism ; In Situ Hybridization, Fluorescence ; Lysine/metabolism ; Methylation ; Mice ; Mice, Knockout ; RNA, Long Noncoding/genetics ; Ubiquitin-Protein Ligases/genetics/*metabolism ; X Chromosome Inactivation/*genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Rice perception of symbiotic arbuscular mycorrhizal fungi requires the karrikin receptor complex (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-12-19
    Description: In terrestrial ecosystems, plants take up phosphate predominantly via association with arbuscular mycorrhizal fungi (AMF). We identified loss of responsiveness to AMF in the rice (Oryza sativa) mutant hebiba, reflected by the absence of physical contact and of characteristic transcriptional responses to fungal signals. Among the 26 genes deleted in hebiba, DWARF 14 LIKE is, the one responsible for loss of symbiosis . It encodes an alpha/beta-fold hydrolase, that is a component of an intracellular receptor complex involved in the detection of the smoke compound karrikin. Our finding reveals an unexpected plant recognition strategy for AMF and a previously unknown signaling link between symbiosis and plant development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gutjahr, Caroline -- Gobbato, Enrico -- Choi, Jeongmin -- Riemann, Michael -- Johnston, Matthew G -- Summers, William -- Carbonnel, Samy -- Mansfield, Catherine -- Yang, Shu-Yi -- Nadal, Marina -- Acosta, Ivan -- Takano, Makoto -- Jiao, Wen-Biao -- Schneeberger, Korbinian -- Kelly, Krystyna A -- Paszkowski, Uta -- PDAG/223 T39/Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2015 Dec 18;350(6267):1521-4. doi: 10.1126/science.aac9715.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Molecular Biology, University of Lausanne, Biophore Building, 1015 Lausanne, Switzerland. Faculty of Biology, Genetics, University of Munich, Biocenter Martinsried, Grosshaderner Strasse 2-4, 82152 Martinsried, Germany. ; Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK. ; Division of Plant Sciences, National Institute of Agrobiological Sciences, 2-1-2 Kannondai, Tsukuba, Ibaraki 305-8602, Japan. Botanical Institute, Molecular Cell Biology, Karlsruhe Institute of Technology, Kaiserstrasse 2, 76131 Karlsruhe, Germany. ; Faculty of Biology, Genetics, University of Munich, Biocenter Martinsried, Grosshaderner Strasse 2-4, 82152 Martinsried, Germany. ; Department of Plant Molecular Biology, University of Lausanne, Biophore Building, 1015 Lausanne, Switzerland. ; Max Planck Institute for Plant Breeding Research, Carl-von-Linne-Weg 10, D-50829 Cologne, Germany. ; Division of Plant Sciences, National Institute of Agrobiological Sciences, 2-1-2 Kannondai, Tsukuba, Ibaraki 305-8602, Japan. ; Department of Plant Molecular Biology, University of Lausanne, Biophore Building, 1015 Lausanne, Switzerland. Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK. up220@cam.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26680197" target="_blank"〉PubMed〈/a〉
    Keywords: Furans/*metabolism ; Hydrolases/genetics/*metabolism ; Mycorrhizae/*physiology ; Oryza/*enzymology/genetics/*microbiology ; Phosphates/metabolism ; Plant Proteins/genetics/*metabolism ; Pyrans/*metabolism ; Symbiosis/genetics/*physiology ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Enhancing glass-forming ability via frustration of nano-clustering in alloys with a high solvent content (2013)
    Springer Nature
    Details
    Publication Date: 2013-06-14
    Description: The glass-forming ability (GFA) of alloys with a high-solvent content such as soft magnetic Fe-based and Al-based alloys is usually limited due to strong formation of the solvent-based solid solution phase. Herein, we report that the GFA of soft magnetic Fe-based alloys (with 〉70 at.% Fe to ensure large saturation magnetization) could be dramatically improved by doping with only 0.3 at.% Cu which has a positive enthalpy of mixing with Fe. It was found that an appropriate Cu addition could enhance the liquid phase stability and crystallization resistance by destabilizing the α-Fe nano-clusters due to the necessity to redistribute the Cu atoms. However, excessive Cu doping would stimulate nucleation of the α-Fe nano-clusters due to the repulsive nature between the Fe and Cu atoms, thus deteriorating the GFA. Our findings provide new insights into understanding of glass formation in general. Scientific Reports 3 doi: 10.1038/srep01983
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 7
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    Numerical investigation on pulsating heat pipes with nitrogen or hydrogen (2017)
    Institute of Physics (IOP)
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    Publication Date: 2017-12-30
    Description: With flexible structure and excellent performance, pulsating heat pipes (PHP) are regarded as a great solution to distribute cooling power for cryocoolers. The experiments on PHPs with cryogenic fluids have been carried out, indicating their efficient performances in cryogenics. There are large differences in physical properties between the fluids at room and cryogenic temperature, resulting in their different heat transfer and oscillation characteristics. Up to now, the numerical investigations on cryogenic fluids have rarely been carried out. In this paper, the model of the closed-loop PHP with multiple liquid slugs and vapor plugs is performed with nitrogen and hydrogen as working fluids, respectively. The effects of heating wall temperature on the performance of close-looped PHPs are investigated and compared with that of water PHP.
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 8
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    Distributions and relationships of virio- and picoplankton in the epi-, meso- and bathypelagic zones of the Western Pacific Ocean (2016)
    Oxford University Press
    Details
    Publication Date: 2016-12-17
    Description: Virio- and picoplankton mediate important biogeochemical processes and the environmental factors that regulate their dynamics, and the virus–host interactions are incompletely known, especially in the deep sea. Here we report on their distributions and relationships with environmental factors at 21 stations covering a latitudinal range (2–23° N) in the Western Pacific Ocean. This region is characterized by a complex western boundary current system. Synechococcus , autotrophic picoeukaryotes, heterotrophic prokaryotes and virus-like particles (VLPs) were high (〈2.4 x 10 2 –6.3 x 10 4 , 〈34–2.8 x 10 3 , 3.9 x 10 4 –1.3 x 10 6 cells mL –1 and 5.1 x 10 5 –2.7 x 10 7 mL –1 , respectively), and Prochlorococcus were low (〈2.3 x 10 2 –1.0 x 10 5 cells mL –1 ) in the Luzon Strait and the four most southerly stations, where upwelling occurs. Covariations in the abundances of VLPs with heterotrophic and autotrophic picoplankton, and their correlation (i.e. r 2 = 0.63 and 0.52, respectively) suggested a strong host dependence in the epi- and mesopelagic zones. In the bathypelagic zone, only abiotic factors significantly influenced VLPs abundance variation ( r 2 = 0.12). This study shows that the dynamics of virio- and picoplankton in this Western Pacific are controlled by suite of complex and depth-dependent relationship among physical and biological factors that in turn link the physical hydrography of the western boundary current system with microbial-mediated biogeochemical processes.
    Print ISSN: 0168-6496
    Electronic ISSN: 1574-6941
    Topics: Biology
    Published by Oxford University Press
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  • 9
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    LKB1 regulates polarized dendrite formation [Neuroscience] (2014)
    National Academy of Sciences
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    Publication Date: 2014-01-08
    Description: Adult-born granule cells in the dentate gyrus of the rodent hippocampus are important for memory formation and mood regulation, but the cellular mechanism underlying their polarized development, a process critical for their incorporation into functional circuits, remains unknown. We found that deletion of the serine-threonine protein kinase LKB1 or overexpression...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 10
    Electronic Resource
    Electronic Resource
    Large-scale fractionation of S-form lipopolysaccharide from salmonella abortus equi - Chemical and serological characterization of the fractions
    Amsterdam : Elsevier
    Journal of Chromatography A 440 (1988), S. 397-404 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0021-9673(00)94543-6
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    Paper (German National Licenses)
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