Publication Date:
2013-08-06
Description:
Predictions about future rewarding events have a powerful influence on behaviour. The phasic spike activity of dopamine-containing neurons, and corresponding dopamine transients in the striatum, are thought to underlie these predictions, encoding positive and negative reward prediction errors. However, many behaviours are directed towards distant goals, for which transient signals may fail to provide sustained drive. Here we report an extended mode of reward-predictive dopamine signalling in the striatum that emerged as rats moved towards distant goals. These dopamine signals, which were detected with fast-scan cyclic voltammetry (FSCV), gradually increased or--in rare instances--decreased as the animals navigated mazes to reach remote rewards, rather than having phasic or steady tonic profiles. These dopamine increases (ramps) scaled flexibly with both the distance and size of the rewards. During learning, these dopamine signals showed spatial preferences for goals in different locations and readily changed in magnitude to reflect changing values of the distant rewards. Such prolonged dopamine signalling could provide sustained motivational drive, a control mechanism that may be important for normal behaviour and that can be impaired in a range of neurologic and neuropsychiatric disorders.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927840/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927840/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Howe, Mark W -- Tierney, Patrick L -- Sandberg, Stefan G -- Phillips, Paul E M -- Graybiel, Ann M -- R01 AG044839/AG/NIA NIH HHS/ -- R01 DA027858/DA/NIDA NIH HHS/ -- R01 MH060379/MH/NIMH NIH HHS/ -- R01 MH079292/MH/NIMH NIH HHS/ -- England -- Nature. 2013 Aug 29;500(7464):575-9. doi: 10.1038/nature12475. Epub 2013 Aug 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23913271" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Animals
;
Dopamine/*metabolism
;
Dopaminergic Neurons/metabolism
;
Goals
;
Male
;
Maze Learning
;
Models, Neurological
;
Models, Psychological
;
Motivation
;
Neostriatum/cytology/*metabolism
;
Rats
;
Rats, Long-Evans
;
*Reward
;
*Signal Transduction
;
Time Factors
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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