Publication Date:
2003-08-30
Description:
Complex biological systems such as human language and the genetic code are characterized by explicit markers at the beginning and end of functional sequences. We report here that macaque prefrontal cortical neurons exhibit phasic peaks of spike activity that occur at the beginning and endpoint of sequential oculomotor saccade performance and have the properties of dynamic start- and end-state encoders accompanying responses to sequential actions. Sequence bounding may thus reflect a general mechanism for encoding biological information.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fujii, Naotaka -- Graybiel, Ann M -- EY12848/EY/NEI NIH HHS/ -- R01 EY012848/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2003 Aug 29;301(5637):1246-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Brain and Cognitive Sciences and McGovern Institute for Brain Research, Massachusetts Institute of Technology, 45 Carleton Street, E25-618, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12947203" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain Mapping
;
Cues
;
Electrodes, Implanted
;
Electrophysiology
;
Female
;
Fixation, Ocular
;
Frontal Lobe/physiology
;
Learning
;
Macaca
;
Neurons/*physiology
;
Prefrontal Cortex/*physiology
;
Psychomotor Performance
;
Reward
;
Saccades/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
