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  • Articles  (22)
  • Medicine  (13)
  • Computer Science  (6)
  • Energy, Environment Protection, Nuclear Power Engineering  (5)
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  • Articles  (22)
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  • 1
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    Sustainability, Vol. 11, Pages 3121: Past Themes and Tracking Research Trends in Entrepreneurship: A Co-Word, Cites and Usage Count Analysis (2019)
    MDPI
    Details
    Publication Date: 2019
    Description: This paper examines the evolution of research in Entrepreneurship published in Web of Science, a reference database. A bibliometric content analysis has been carried out as part of this investigation, allowing for a longitudinal study of the main research topics dealt with over time, ranging from classic topics such as its conception to more recent realities that include Social and Sustainable Entrepreneurship. This paper locates research trends by studying the evolution of citations and by incorporating use metrics. The results point to the existence of seven cognitive fronts that have marked the field’s growth and conceptual evolution. Furthermore, evidence is presented that shows how innovation has historically been the thread that links all the core themes. The topics and trends detected contribute specially to advancing the current discussion on entrepreneurship and coordinating future research efforts.
    Electronic ISSN: 2071-1050
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI
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  • 2
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    Environment. Environmental monitoring network for India (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-04-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sundareshwar, P V -- Murtugudde, R -- Srinivasan, G -- Singh, S -- Ramesh, K J -- Ramesh, R -- Verma, S B -- Agarwal, D -- Baldocchi, D -- Baru, C K -- Baruah, K K -- Chowdhury, G R -- Dadhwal, V K -- Dutt, C B S -- Fuentes, J -- Gupta, Prabhat K -- Hargrove, W W -- Howard, M -- Jha, C S -- Lal, S -- Michener, W K -- Mitra, A P -- Morris, J T -- Myneni, R R -- Naja, M -- Nemani, R -- Purvaja, R -- Raha, S -- Vanan, S K Santhana -- Sharma, M -- Subramaniam, A -- Sukumar, R -- Twilley, R R -- Zimmerman, P R -- New York, N.Y. -- Science. 2007 Apr 13;316(5822):204-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Atmospheric Sciences, South Dakota School of Mines and Technology, Rapid City, SD 57701, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17431156" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    Unfolding and trypsin inactivation studies reveal a conformation drift of glucose-6-phosphate dehydrogenase upon binding of NADP
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 1122 (1992), S. 99-106 
    Details
    ISSN: 0167-4838
    Keywords: Glucose-6-phosphate dehydrogenase ; Guanidine hydrochloride ; NADP ; Thermal denaturation ; Trypsin ; Unfolding
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0167-4838(92)90133-X
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  • 4
    Electronic Resource
    Electronic Resource
    Crayfish stretch-receptor organs: Effects of length-steps with and without perturbations (1978)
    Springer
    Biological cybernetics 31 (1978), S. 99-110 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract Isolated slowly and fast adapting stretch receptor organs (SROs) of crayfish were submitted to step-like length changes separated by prolonged stations with constant lengths. At times they were perturbed by a small-amplitude, fast length variation representing natural pertubations and referred to as “jitter”. Stimulus “cycles” depended on the sequence of lengths and on whether jitter was present. First-order afferent discharges were recorded from the dorsal nerve. Firing intensity, measured by the rate over bins of about 1 s, was displayed along ongoing time. Quantification involved estimation of cycle histograms, and trend tests for fully adapted discharges and preparation stability. The behaviour perturbed by jitter differed quantitatively in both organs from that without jitter, apart from more intense and irregular firing. Differences were also qualitative in the rapidly adapting organ (RAO), that jitter kept firing almost unccasingly and changed from a “transient detector” to a “tonic receptor”. Jitter effects varied with background stretch. The slowly adapting organ (SAO) and the perturbed RAO behaved quite similarly and exhibited features of lead-lag linear systems that implied joint sensitivity to length and velocity, like lively accelerations after stretches and lively slowings after relaxations with subsequent adaptation to steady discharges. Shortenings provided as important stimuli as lengthenings. At constant lengths, discharges eventually reached “full adaptation”: full adaptation cannot be proven experimentally, but can be accepted in practice using statistically sound and physiologically pragmatic criteria. When fully adapted, the SAO and the perturbed RAO had length-dependent discharges. Both SROs exhibited also prominent non-linear features besides the expected limiter behavior. Responses to symmetric stimuli were asymmetric: e.g. lengthenings produced greater rate changes and more durable transients than shortenings. The coding from steady lengths to fully-adapted discharges was multivalued (except in the unperturbed RAO): discharges were more or less intense depending on whether the particular length had been reached through lengthening or shortening, respectively (“hysteresis”). The anatomical and physiological reasons for many of these linear or nonlinear features are not yet identified fully. Discharge profiles deviated (in mean squared error) from the corresponding stimuli less with jitter than without. This happened, in spite of increased fluctuations in successive bins, because of reductions in transient effects and in delays to full adaptation. Length identification on the basis of the afferent discharges was improved by jitter, because of the above and because of reduction of the multivaluedness. The consequences of this more faithful representation are contingent on the neuronal analyzer to which the discharges are presented. The issues discussed, like full adaptation, multivaluedness, and the implications of the perturbations are relevant to mechanoreceptors in general, and even to all receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00344241
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of foliage wetness on the dry deposition of ozone onto red maple and poplar leaves (1994)
    Springer
    Water, air & soil pollution 74 (1994), S. 189-210 
    Details
    ISSN: 1573-2932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The deposition of ozone onto hypostomatous red maple and amphistomatous hybrid poplar leaves was studied under controlled environments. Under similar environmental conditions, the ozone deposition was substantially greater onto poplar than onto maple leaves. Two kinds of surface wetness (simulating dew and raindrops) were artificially created on leaves to determine how deposition was affected. The ozone deposition onto wet maple leaves markedly increased almost immediately after water spraying. The increases were measured during both daytime and nighttime conditions. Nighttime measurements revealed that the enhanced ozone deposition onto wet maple leaves was largely controlled by the chemistry of the solution which eventually developed while leaves remained wet. Unlike maple leaves, small ozone deposition reductions were measured after poplar leaves became wet during daytime conditions. In addition, little ozone deposition was detected onto wet poplar leaves during the night, indicating that leaf water chemistry was less important for poplar than for maple leaves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01257155
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  • 6
    Electronic Resource
    Electronic Resource
    Ketoconazole in Paracoccidioidomycosis: Efficacy of prolonged oral therapy (1980)
    Springer
    Mycopathologia 72 (1980), S. 35-45 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Sumario Un nuevo derivado del imidazole para uso oral, ketoconazole, fué empleado en el tratamiento de 5 pacientes con paracoccidioidomicosis. Se condujo la terapia por un año, con base a la administración de una pastilla (200 mg) por día en 2 pacientes; en los 3 restantes, esta dosis fué reducida a la mitad y mantenida en tal nivel por otros 6 meses. La respuesta fué excelente con mejoría clínica objetiva y cicatrización de las lesiones tegumentarias y pulmonares. Los estudios micológicos y serológicos, a la par que la sensibilidad cutanea, llevados a cabo durante el curso del tratamiento indicaron también mejoría. No se anotó ninguna toxicidad para la droga ni los pacientes experimentaron efectos secundarios. Las ventajas de esta nueva clase de terapia son discutidas en el texto.
    Notes: Summary Ketoconazole, a new oral imidazole derivative, was employed for the treatment of five patients with paracoccidioidomycosis. The response was excellent, with objective clinical improvement and healing of both mucocutaneous and pulmonary lesions. Mycological and serological tests, as well as delayed hypersensitivity, were assessed and found to correlate with clinical improvement. Therapy was conducted for 12 months with a dose of 200 mg day in 2 patients; in the remainder the dose was reduced (100 mg day) after the first 6 months and maintained as such for an equal period. No side-effects or toxicity were noted despite prolonged treatment. The advantages of the new therapeutic approach are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443049
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  • 7
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    A Method to Find Functional Dependencies Through Refutations and Duality of Hypergraphs (2015)
    Oxford University Press
    Details
    Publication Date: 2015-05-03
    Description: One of the most important steps in obtaining a relational model from legacy systems is the extraction of functional dependencies (FDs) through data mining techniques. Several methods have been proposed for this purpose and most use direct search methods that traverse the search space in exponential time in the number of attributes of the relation. As it is not uncommon to find in practice relations with tens of attributes, a need exists to further develop more efficient techniques to find FDs. The method studied here finds the minimal set of minimal FDs using algorithms that solve the hypergraph duality problem applied on the complement of the refutation hypergraph of the relation without going through the exponential search space. After showing that the extraction of FDs can be reduced to the hypergraph duality problem, experimental results are given as verification and characterization of the correctness and time complexity of the proposed tool.
    Print ISSN: 0010-4620
    Electronic ISSN: 1460-2067
    Topics: Computer Science
    Published by Oxford University Press
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  • 8
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    Distribution of peptidergic populations in the human dentate gyrus (Somatostatin [SOM-28, SOM-12] and Neuropeptide Y [NPY]) during postnatal development (2014)
    Springer
    Details
    Publication Date: 2014-06-26
    Print ISSN: 0302-766X
    Electronic ISSN: 1432-0878
    Topics: Biology , Medicine
    Published by Springer
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  • 9
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    From the beginning: the basal transcription machinery and onset of transcription in the early animal embryo (2007)
    Springer
    Details
    Publication Date: 2007-10-15
    Print ISSN: 1420-682X
    Electronic ISSN: 1420-9071
    Topics: Biology , Medicine
    Published by Springer
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  • 10
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    3, 3',5-Triiodo-L-Thyronine Increases In Vitro Chondrogenesis of Mesenchymal Stem Cells from Human Umbilical Cord Stroma Through SRC2 (2016)
    Wiley
    Details
    Publication Date: 2016-02-13
    Description: ABSTRACT Objective Our group focuses on the study of mesenchymal stem cells (MSCs) from human umbilical cord stroma or Warthon's jelly and their directed differentiation toward chondrocyte-like cells capable of regenerating damaged cartilage when transplanted into an injured joint. This study aimed to determine whether lactogenic hormone prolactin (PRL) or 3, 3', 5-triiodo-L-thyronine (T3), the active thyroid hormone, modulates chondrogenesis in our in vitro model of directed chondrogenic differentiation, and whether Wnt signalling is involved in this modulation. Results MSCs from human umbilical cord stroma underwent directed differentiation toward chondrocyte-like cells by spheroid formation. The addition of T3 to the chondrogenic medium increased the expression of genes linked to chondrogenesis like collagen type 2 , integrin alpha 10 beta 1 and Sox9 measured by quantitative real time polymerase chain reaction (qRT-PCR) analysis. Levels of collagen type 2 and aggrecane analyzed by immunohistochemistry, and staining by Safranin O were increased after 14 days in spheroid culture with T3 compared to those without T3 or only with PRL. B-catenin, Frizzled and GSK-3β gene expressions were significantly higher in spheroids cultured with chondrogenic medium (CM) plus T3 compared to CM alone after 14 days in culture. The increase of chondrogenic differentiation was inhibited when the cells were treated with T3 plus ML151, an inhibitor of the T3 steroid receptor. Conclusion This work demonstrates, for first time, that T3 promotes differentiation towards chondrocytes-like cells in our in vitro model, that this differentiation is mediated by steroid receptor co-activator 2 (SRC2) and does not induce hypertrophy. This article is protected by copyright. All rights reserved
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley
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