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  • 1
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    Impact of genome reduction on bacterial metabolism and its regulation (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-12-08
    Description: To understand basic principles of bacterial metabolism organization and regulation, but also the impact of genome size, we systematically studied one of the smallest bacteria, Mycoplasma pneumoniae. A manually curated metabolic network of 189 reactions catalyzed by 129 enzymes allowed the design of a defined, minimal medium with 19 essential nutrients. More than 1300 growth curves were recorded in the presence of various nutrient concentrations. Measurements of biomass indicators, metabolites, and 13C-glucose experiments provided information on directionality, fluxes, and energetics; integration with transcription profiling enabled the global analysis of metabolic regulation. Compared with more complex bacteria, the M. pneumoniae metabolic network has a more linear topology and contains a higher fraction of multifunctional enzymes; general features such as metabolite concentrations, cellular energetics, adaptability, and global gene expression responses are similar, however.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yus, Eva -- Maier, Tobias -- Michalodimitrakis, Konstantinos -- van Noort, Vera -- Yamada, Takuji -- Chen, Wei-Hua -- Wodke, Judith A H -- Guell, Marc -- Martinez, Sira -- Bourgeois, Ronan -- Kuhner, Sebastian -- Raineri, Emanuele -- Letunic, Ivica -- Kalinina, Olga V -- Rode, Michaela -- Herrmann, Richard -- Gutierrez-Gallego, Ricardo -- Russell, Robert B -- Gavin, Anne-Claude -- Bork, Peer -- Serrano, Luis -- New York, N.Y. -- Science. 2009 Nov 27;326(5957):1263-8. doi: 10.1126/science.1177263.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Genomic Regulation (CRG) and Universitat Pompeu Fabra, Avenida Dr. Aiguader 88, 08003 Barcelona, Spain.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19965476" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Bacterial Proteins/*metabolism ; Culture Media ; Energy Metabolism ; Enzymes/genetics/metabolism ; Gene Expression Profiling ; *Gene Expression Regulation, Bacterial ; *Genome, Bacterial ; Glycolysis ; *Metabolic Networks and Pathways ; Mycoplasma pneumoniae/*genetics/growth & development/*metabolism ; RNA, Bacterial/genetics/metabolism ; Signal Transduction ; Systems Biology ; Transcription, Genetic ; rRNA Operon
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Immunity-related genes and gene families in Anopheles gambiae (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-05
    Description: We have identified 242 Anopheles gambiae genes from 18 gene families implicated in innate immunity and have detected marked diversification relative to Drosophila melanogaster. Immune-related gene families involved in recognition, signal modulation, and effector systems show a marked deficit of orthologs and excessive gene expansions, possibly reflecting selection pressures from different pathogens encountered in these insects' very different life-styles. In contrast, the multifunctional Toll signal transduction pathway is substantially conserved, presumably because of counterselection for developmental stability. Representative expression profiles confirm that sequence diversification is accompanied by specific responses to different immune challenges. Alternative RNA splicing may also contribute to expansion of the immune repertoire.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Christophides, George K -- Zdobnov, Evgeny -- Barillas-Mury, Carolina -- Birney, Ewan -- Blandin, Stephanie -- Blass, Claudia -- Brey, Paul T -- Collins, Frank H -- Danielli, Alberto -- Dimopoulos, George -- Hetru, Charles -- Hoa, Ngo T -- Hoffmann, Jules A -- Kanzok, Stefan M -- Letunic, Ivica -- Levashina, Elena A -- Loukeris, Thanasis G -- Lycett, Gareth -- Meister, Stephan -- Michel, Kristin -- Moita, Luis F -- Muller, Hans-Michael -- Osta, Mike A -- Paskewitz, Susan M -- Reichhart, Jean-Marc -- Rzhetsky, Andrey -- Troxler, Laurent -- Vernick, Kenneth D -- Vlachou, Dina -- Volz, Jennifer -- von Mering, Christian -- Xu, Jiannong -- Zheng, Liangbiao -- Bork, Peer -- Kafatos, Fotis C -- New York, N.Y. -- Science. 2002 Oct 4;298(5591):159-65.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12364793" target="_blank"〉PubMed〈/a〉
    Keywords: Alternative Splicing ; Animals ; Anopheles/*genetics/*immunology/metabolism/microbiology/parasitology ; Apoptosis ; Bacteria/immunology ; Catechol Oxidase/metabolism ; Computational Biology ; Drosophila Proteins/chemistry/genetics/metabolism ; Drosophila melanogaster/genetics/immunology/metabolism ; Enzyme Precursors/metabolism ; Gene Expression Regulation ; *Genes, Insect ; Genome ; Immunity, Innate ; Insect Proteins/chemistry/genetics/metabolism ; Multigene Family ; Peptides/metabolism ; Phylogeny ; Plasmodium/immunology/physiology ; Protein Structure, Tertiary ; Selection, Genetic ; Serine Endopeptidases/metabolism ; Serpins/metabolism ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
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