Publication Date:
2008-08-01
Description:
The gut-derived hormone ghrelin exerts its effect on the brain by regulating neuronal activity. Ghrelin-induced feeding behaviour is controlled by arcuate nucleus neurons that co-express neuropeptide Y and agouti-related protein (NPY/AgRP neurons). However, the intracellular mechanisms triggered by ghrelin to alter NPY/AgRP neuronal activity are poorly understood. Here we show that ghrelin initiates robust changes in hypothalamic mitochondrial respiration in mice that are dependent on uncoupling protein 2 (UCP2). Activation of this mitochondrial mechanism is critical for ghrelin-induced mitochondrial proliferation and electric activation of NPY/AgRP neurons, for ghrelin-triggered synaptic plasticity of pro-opiomelanocortin-expressing neurons, and for ghrelin-induced food intake. The UCP2-dependent action of ghrelin on NPY/AgRP neurons is driven by a hypothalamic fatty acid oxidation pathway involving AMPK, CPT1 and free radicals that are scavenged by UCP2. These results reveal a signalling modality connecting mitochondria-mediated effects of G-protein-coupled receptors on neuronal function and associated behaviour.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101536/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101536/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Andrews, Zane B -- Liu, Zhong-Wu -- Walllingford, Nicholas -- Erion, Derek M -- Borok, Erzsebet -- Friedman, Jeffery M -- Tschop, Matthias H -- Shanabrough, Marya -- Cline, Gary -- Shulman, Gerald I -- Coppola, Anna -- Gao, Xiao-Bing -- Horvath, Tamas L -- Diano, Sabrina -- R01 AG022880/AG/NIA NIH HHS/ -- R01 DK040936/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2008 Aug 14;454(7206):846-51. doi: 10.1038/nature07181. Epub 2008 Jul 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Comparative Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, Howard Hughes Medical Institute, New York, New York 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18668043" target="_blank"〉PubMed〈/a〉
Keywords:
Agouti-Related Protein/genetics/*metabolism
;
Animals
;
Carnitine O-Palmitoyltransferase/metabolism
;
Fatty Acids/metabolism
;
Feeding Behavior/drug effects
;
Gene Expression Regulation/drug effects
;
Ghrelin/*metabolism/pharmacology
;
Hypothalamus/drug effects/metabolism
;
Ion Channels/genetics/*metabolism
;
Membrane Potential, Mitochondrial/drug effects/physiology
;
Mice
;
Mitochondria/drug effects/physiology
;
Mitochondrial Proteins/genetics/*metabolism
;
Neurons/drug effects/*metabolism
;
Neuropeptide Y/genetics/*metabolism
;
Phosphorylation/drug effects
;
Reactive Oxygen Species/*metabolism
;
Synapses/drug effects/metabolism
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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