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  • Electronic structure and strongly correlated systems  (8)
  • Humans  (6)
  • 1
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    Polarization-analyzed resonant inelastic x-ray scattering of the orbital excitations in KCuF_{3} (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-06-17
    Description: Author(s): K. Ishii, S. Ishihara, Y. Murakami, K. Ikeuchi, K. Kuzushita, T. Inami, K. Ohwada, M. Yoshida, I. Jarrige, N. Tatami, S. Niioka, D. Bizen, Y. Ando, J. Mizuki, S. Maekawa, and Y. Endoh We report a Cu K edge resonant inelastic x-ray scattering (RIXS) study of the orbital excitations in the orbital-ordered Mott insulator KCuF 3 . By performing the polarization analysis of the scattered photons, the excitation between the e g orbitals is successfully distinguished from the excitations fr... [Phys. Rev. B 83, 241101] Published Thu Jun 16, 2011
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    Momentum-resolved electronic excitations in the Mott insulator Sr_{2} IrO_{4} studied by resonant inelastic x-ray scattering (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-03-15
    Description: Author(s): K. Ishii, I. Jarrige, M. Yoshida, K. Ikeuchi, J. Mizuki, K. Ohashi, T. Takayama, J. Matsuno, and H. Takagi We report an Ir L_{3} edge resonant inelastic x-ray scattering measurement of the low-lying electronic excitations in Sr_{2} IrO_{4} over the complete Brillouin zone of the IrO_{2} plane. A remarkably strong inelastic signal which exceeds the elastic scattering in intensity is observed. Peaks observ... [Phys. Rev. B 83, 115121] Published Mon Mar 14, 2011
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-12-16
    Description: Metastatic progression of cancer is a complex and clinically daunting process. We previously identified a set of human microRNAs (miRNAs) that robustly suppress breast cancer metastasis to lung and bone and which display expression levels that predict human metastasis. Although these findings revealed miRNAs as suppressors of cell-autonomous metastatic phenotypes, the roles of non-coding RNAs in non-cell-autonomous cancer progression processes remain unknown. Here we reveal that endogenous miR-126, an miRNA silenced in a variety of common human cancers, non-cell-autonomously regulates endothelial cell recruitment to metastatic breast cancer cells, in vitro and in vivo. It suppresses metastatic endothelial recruitment, metastatic angiogenesis and metastatic colonization through coordinate targeting of IGFBP2, PITPNC1 and MERTK--novel pro-angiogenic genes and biomarkers of human metastasis. Insulin-like growth factor binding protein 2 (IGFBP2) secreted by metastatic cells recruits endothelia by modulating IGF1-mediated activation of the IGF type-I receptor on endothelial cells; whereas c-Mer tyrosine kinase (MERTK) receptor cleaved from metastatic cells promotes endothelial recruitment by competitively antagonizing the binding of its ligand GAS6 to endothelial MERTK receptors. Co-injection of endothelial cells with breast cancer cells non-cell-autonomously rescues their miR-126-induced metastatic defect, revealing a novel and important role for endothelial interactions in metastatic initiation. Through loss-of-function and epistasis experiments, we delineate an miRNA regulatory network's individual components as novel and cell-extrinsic regulators of endothelial recruitment, angiogenesis and metastatic colonization. We also identify the IGFBP2/IGF1/IGF1R and GAS6/MERTK signalling pathways as regulators of cancer-mediated endothelial recruitment. Our work further reveals endothelial recruitment and endothelial interactions in the tumour microenvironment to be critical features of metastatic breast cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Png, Kim J -- Halberg, Nils -- Yoshida, Mitsukuni -- Tavazoie, Sohail F -- England -- Nature. 2011 Dec 14;481(7380):190-4. doi: 10.1038/nature10661.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Systems Cancer Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22170610" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breast Neoplasms/blood supply/*genetics/*pathology ; Cell Adhesion ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Endothelium, Vascular/*pathology ; Epistasis, Genetic ; Female ; Gene Expression Regulation, Neoplastic ; Human Umbilical Vein Endothelial Cells ; Humans ; Insulin-Like Growth Factor I/metabolism ; Intercellular Signaling Peptides and Proteins/metabolism ; Liver Neoplasms/blood supply/pathology/secondary ; Lung Neoplasms/blood supply/pathology/secondary ; Membrane Transport Proteins/genetics/metabolism ; Mice ; Mice, Inbred NOD ; Mice, SCID ; MicroRNAs/*genetics ; *Neoplasm Metastasis/genetics/pathology ; Neoplasm Transplantation ; Neovascularization, Pathologic/*genetics/pathology ; Proto-Oncogene Proteins/genetics/metabolism ; RNA-Binding Proteins/genetics/metabolism ; Receptor Protein-Tyrosine Kinases/genetics/metabolism ; Receptor, IGF Type 1/metabolism ; Regulon/*genetics ; Signal Transduction ; Survival Analysis
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Mutations in the dystrophin-associated protein gamma-sarcoglycan in chromosome 13 muscular dystrophy (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-11-03
    Description: Severe childhood autosomal recessive muscular dystrophy (SCARMD) is a progressive muscle-wasting disorder common in North Africa that segregates with microsatellite markers at chromosome 13q12. Here, it is shown that a mutation in the gene encoding the 35-kilodalton dystrophin-associated glycoprotein, gamma-sarcoglycan, is likely to be the primary genetic defect in this disorder. The human gamma-sarcoglycan gene was mapped to chromosome 13q12, and deletions that alter its reading frame were identified in three families and one of four sporadic cases of SCARMD. These mutations not only affect gamma-sarcoglycan but also disrupt the integrity of the entire sarcoglycan complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Noguchi, S -- McNally, E M -- Ben Othmane, K -- Hagiwara, Y -- Mizuno, Y -- Yoshida, M -- Yamamoto, H -- Bonnemann, C G -- Gussoni, E -- Denton, P H -- Kyriakides, T -- Middleton, L -- Hentati, F -- Ben Hamida, M -- Nonaka, I -- Vance, J M -- Kunkel, L M -- Ozawa, E -- NS23740/NS/NINDS NIH HHS/ -- P01-NS26630/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1995 Nov 3;270(5237):819-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute of Neuroscience, National Center for Neurology and Psychiatry, Tokyo, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481775" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Chromosome Mapping ; *Chromosomes, Human, Pair 13 ; *Cytoskeletal Proteins ; DNA, Complementary/genetics ; Dystrophin/chemistry/genetics/metabolism ; Humans ; Linkage Disequilibrium ; Membrane Glycoproteins/chemistry/*genetics/metabolism ; Molecular Sequence Data ; Molecular Weight ; Muscle, Skeletal/chemistry/metabolism ; Muscular Dystrophies/*genetics ; Mutation ; Phenotype ; Rabbits ; Sarcoglycans ; Sequence Deletion
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-05-05
    Description: Medical applications of nanotechnology typically focus on drug delivery and biosensors. Here, we combine nanotechnology and bioengineering to demonstrate that nanoparticles can be used to remotely regulate protein production in vivo. We decorated a modified temperature-sensitive channel, TRPV1, with antibody-coated iron oxide nanoparticles that are heated in a low-frequency magnetic field. When local temperature rises, TRPV1 gates calcium to stimulate synthesis and release of bioengineered insulin driven by a Ca(2+)-sensitive promoter. Studying tumor xenografts expressing the bioengineered insulin gene, we show that exposure to radio waves stimulates insulin release from the tumors and lowers blood glucose in mice. We further show that cells can be engineered to synthesize genetically encoded ferritin nanoparticles and inducibly release insulin. These approaches provide a platform for using nanotechnology to activate cells.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646550/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646550/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stanley, Sarah A -- Gagner, Jennifer E -- Damanpour, Shadi -- Yoshida, Mitsukuni -- Dordick, Jonathan S -- Friedman, Jeffrey M -- R01 GM095654/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 May 4;336(6081):604-8. doi: 10.1126/science.1216753.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22556257" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bioengineering ; Blood Glucose/*analysis ; Calcium/*metabolism ; Embryonic Stem Cells/metabolism ; Epitopes ; *Ferric Compounds ; Ferritins/administration & dosage/genetics/metabolism ; HEK293 Cells ; Hot Temperature ; Humans ; Insulin/blood/genetics/*metabolism ; Male ; *Metal Nanoparticles ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Neoplasms, Experimental/blood/pathology ; PC12 Cells ; *Radio Waves ; Rats ; Recombinant Fusion Proteins/administration & dosage ; TRPV Cation Channels/genetics/immunology/*metabolism ; Transfection ; Transplantation, Heterologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Resonant inelastic x-ray scattering study of charge excitations in superconducting and nonsuperconducting PrFeAsO_{1−y} (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-09-06
    Description: Author(s): I. Jarrige, T. Nomura, K. Ishii, H. Gretarsson, Y.-J. Kim, J. Kim, M. Upton, D. Casa, T. Gog, M. Ishikado, T. Fukuda, M. Yoshida, J. P. Hill, X. Liu, N. Hiraoka, K. D. Tsuei, and S. Shamoto We report the first observation by momentum-resolved resonant inelastic x-ray scattering of charge excitations in an iron-based superconductor and its parent compound, PrFeAsO 0.7 and PrFeAsO, respectively, with two main results. First, using calculations based on a 16-band d p model, we show that the... [Phys. Rev. B 86, 115104] Published Wed Sep 05, 2012
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 7
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    Three-dimensional band structure of LaSb and CeSb: Absence of band inversion (2017)
    American Physical Society (APS)
    Details
    Publication Date: 2017-07-19
    Description: Author(s): H. Oinuma, S. Souma, D. Takane, T. Nakamura, K. Nakayama, T. Mitsuhashi, K. Horiba, H. Kumigashira, M. Yoshida, A. Ochiai, T. Takahashi, and T. Sato We have performed angle-resolved photoemission spectroscopy (ARPES) of LaSb and CeSb, a candidate of topological insulators. Using soft-x-ray photons, we have accurately determined the three-dimensional bulk band structure and revealed that the band inversion at the Brillouin-zone corner, a prerequi... [Phys. Rev. B 96, 041120(R)] Published Tue Jul 18, 2017
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 8
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    Retrovirus terminology (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Watanabe, T -- Seiki, M -- Yoshida, M -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1178.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316504" target="_blank"〉PubMed〈/a〉
    Keywords: Deltaretrovirus ; Humans ; Leukemia ; Lymphoma ; *Retroviridae ; T-Lymphocytes ; *Terminology as Topic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Location of the c-yes gene on the human chromosome and its expression in various tissues (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-03-01
    Description: Analysis of DNA from human embryo fibroblasts showed that ten Eco RI fragments were hybridizable with the Yamaguchi sarcoma virus oncogene (v-yes). Four of the Eco RI fragments were assigned to chromosome 18 and one to chromosome 6. There was evidence for multiple copies of yes-related genes in the human genome; however, only a single RNA species, 4.8 kilobases in length, was related to yes in various cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Semba, K -- Yamanashi, Y -- Nishizawa, M -- Sukegawa, J -- Yoshida, M -- Sasaki, M -- Yamamoto, T -- Toyoshima, K -- New York, N.Y. -- Science. 1985 Mar 1;227(4690):1038-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2983418" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avian Sarcoma Viruses/genetics ; Base Sequence ; *Chromosome Mapping ; Chromosomes, Human, 16-18 ; Chromosomes, Human, 6-12 and X ; DNA/genetics ; Humans ; Hybrid Cells/metabolism ; Mice ; Nucleic Acid Hybridization ; *Oncogenes ; Transduction, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Expression of the pX gene of HTLV-I: general splicing mechanism in the HTLV family (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-06-28
    Description: Human T-cell leukemia virus type I (HTLV-I) is an etiological agent of adult T-cell leukemia. A viral gene pX encodes for p40X and it has been proposed that this protein trans-activates the viral long terminal repeat and possibly some cellular genes; this activation may be associated with T-cell transformation. The mechanism of pX gene expression and the primary structure of p40X are now reported. Two-step splicing generates the 2.1-kilobase pX mRNA; the initiator methionine for env becomes part of the pX protein. These splicing signals are conserved among all members of the HTLV family except for the acquired immune deficiency syndrome-associated viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seiki, M -- Hikikoshi, A -- Taniguchi, T -- Yoshida, M -- New York, N.Y. -- Science. 1985 Jun 28;228(4707):1532-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2990031" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; DNA/analysis ; DNA Restriction Enzymes/metabolism ; DNA, Viral/analysis ; Deltaretrovirus/*genetics ; *Gene Expression Regulation ; Humans ; Nucleic Acid Conformation ; *RNA Splicing ; RNA, Viral/analysis ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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