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  • Calcineurin Thymus Hassall's corpuscles Epidermis Immunohistochemistry  (1)
  • Nutrient supply  (1)
  • Peat mat  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Immunolocalization of calcineurin and FKBP12, the FK506-binding protein, in Hassall's corpuscles of human thymus and epidermis (2000)
    Springer
    Histochemistry and cell biology 114 (2000), S. 9-14 
    Details
    ISSN: 1432-119X
    Keywords: Calcineurin Thymus Hassall's corpuscles Epidermis Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, plays an important role in various physiological functions including T cell activation. This enzyme is a target molecule for the immunosuppressants, cyclosporin A and FK506. In the present study, we investigated immunohistochemical localization of calcineurin and FKBP12, an FK506-binding protein, in human thymus and epidermis. The catalytic subunit (calcineurin A) of calcineurin was abundantly expressed in Hassall's corpuscles which were localized in the thymic medulla and represented the terminal stages of thymic medullary epithelium. The regulatory subunit (calcineurin B) of calcineurin was also expressed in high amounts in Hassall's corpuscles. In the epidermis, which shows similarities to Hassall's corpuscles, both subunits were also abundantly expressed, and their expression increased with the differentiation of keratinocytes. FKBP12 was observed to be expressed abundantly, both in Hassall's corpuscles and the entire epidermis. These findings suggest that the differentiated forms of the two cell types, which are the thymic medullary epithelial cell and the keratinocyte, are the target for pharmacological actions of FK506.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004180000168
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  • 2
    Electronic Resource
    Electronic Resource
    Nutrient dynamics in a floating mat and pond system with special reference to its vegetation (1990)
    Springer
    Ecological research 5 (1990), S. 63-79 
    Details
    ISSN: 1440-1703
    Keywords: Floating mat ; Mizorogaike Pond ; Nutrient supply ; Peat mat ; Water chemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Chemical properties of waters and their seasonal changes were studied in Mizorogaike Pond, a system of pond and floating mat. The following six sites including contrasting habitats and water conditions were monitored to assess nutrient dynamics in the system: 1) a pool on the mat, 2) margin of aSphagnum cuspidatum community, 3) an artificial ‘well’ (water layer beneath the floating mat), 4) aMenyanthes trifoliata community in a hollow, and 5) & 6) two sites in the open water. On the floating mat, the water around theSphagnum community had lower pH values, while that in theM. trifoliata community had higher pH values. This difference was related to the influence of flood water, the extent of which was determined by the microtopography. Seasonal changes in water chemistry on the mat suggested that pond water flooding the mat in late autumn and winter is important for the nutrient supply to the mat surface vegetation in this system. Water chemistry of the ‘well’ suggested that the diffusion of inorganic nitrogen occurs from beneath the peat layer. Two types of cluster analysis based on the mean values for chemical variables and the patterns of fluctuation in these variables were performed. The six sites were classified into similar groups which were identified by water type (pool, hollow, well and open water) by both types of analysis. The results showed that a common kind of perturbation should operate in determining the status of nutrient dynamics in the various water types.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02348464
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    Paper (German National Licenses)
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