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  • 1
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    Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-05-30
    Description: As alterations in tissue pH underlie many pathological processes, the capability to image tissue pH in the clinic could offer new ways of detecting disease and response to treatment. Dynamic nuclear polarization is an emerging technique for substantially increasing the sensitivity of magnetic resonance imaging experiments. Here we show that tissue pH can be imaged in vivo from the ratio of the signal intensities of hyperpolarized bicarbonate (H(13)CO(3)(-)) and (13)CO(2) following intravenous injection of hyperpolarized H(13)CO(3)(-). The technique was demonstrated in a mouse tumour model, which showed that the average tumour interstitial pH was significantly lower than the surrounding tissue. Given that bicarbonate is an endogenous molecule that can be infused in relatively high concentrations into patients, we propose that this technique could be used clinically to image pathological processes that are associated with alterations in tissue pH, such as cancer, ischaemia and inflammation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallagher, Ferdia A -- Kettunen, Mikko I -- Day, Sam E -- Hu, De-En -- Ardenkjaer-Larsen, Jan Henrik -- Zandt, Rene in 't -- Jensen, Pernille R -- Karlsson, Magnus -- Golman, Klaes -- Lerche, Mathilde H -- Brindle, Kevin M -- C197/A3514/Cancer Research UK/United Kingdom -- England -- Nature. 2008 Jun 12;453(7197):940-3. doi: 10.1038/nature07017. Epub 2008 May 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18509335" target="_blank"〉PubMed〈/a〉
    Keywords: Acid-Base Equilibrium ; Animals ; Bicarbonates/*metabolism ; Carbon Dioxide/metabolism ; Carbon Isotopes ; Carbonic Anhydrases/metabolism ; Catalysis ; Hydrogen-Ion Concentration ; Lymphoma/*diagnosis/*metabolism/pathology ; Magnetic Resonance Imaging/*methods ; Mice ; Neoplasm Transplantation ; Phantoms, Imaging
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-12-20
    Description: Adipocyte differentiation is an important component of obesity and other metabolic diseases. This process is strongly inhibited by many mitogens and oncogenes. Several growth factors that inhibit fat cell differentiation caused mitogen-activated protein (MAP) kinase-mediated phosphorylation of the dominant adipogenic transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) and reduction of its transcriptional activity. Expression of PPARgamma with a nonphosphorylatable mutation at this site (serine-112) yielded cells with increased sensitivity to ligand-induced adipogenesis and resistance to inhibition of differentiation by mitogens. These results indicate that covalent modification of PPARgamma by serum and growth factors is a major regulator of the balance between cell growth and differentiation in the adipose cell lineage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hu, E -- Kim, J B -- Sarraf, P -- Spiegelman, B M -- R37DK31405/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1996 Dec 20;274(5295):2100-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8953045" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Adipocytes/*cytology/metabolism ; Animals ; Blood ; Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors/*metabolism ; Cell Differentiation ; Cell Line ; Enzyme Inhibitors/pharmacology ; Epidermal Growth Factor/pharmacology ; Flavonoids/pharmacology ; Insulin/pharmacology ; Ligands ; Mice ; Mitogens/pharmacology ; Mutation ; Phosphorylation ; Rats ; Receptors, Cytoplasmic and Nuclear/chemistry/genetics/*metabolism ; Tetradecanoylphorbol Acetate/pharmacology ; Transcription Factors/chemistry/genetics/*metabolism ; Transcription, Genetic/drug effects ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    The Hawaii K-band galaxy survey. 1: Deep K-band imaging (1994)
    In:  Other Sources
    Details
    Publication Date: 2019-08-27
    Description: We present the results of a very deep K-band survey with a 5 sigma total galaxy magnitude limit of K = 21.9 in the deepest field. A 5 sigma K-band-selected sample of 123 galaxies is presented, together with their optical colors. Only three galaxies in this sample are not detected at the 1 sigma level in Kron-Cousins I band. At K less than or = 20 the reddest (I-K) color is 5.1 +/- 0.4, and 15 of the 123 objects in the deep field sample have (I-K) greater than 4. In the blue, the galaxies show a rapid blueward trend at magnitudes beyond K = 19, dropping from a median (B-K) = 6 at K = 18 to a median (B-K) of only 4.2 at K = 21.5. The surface density of (I-K) greater than 4 objects is interpreted to imply either that there is a significant evolution toward later types in the colors of the normal galaxy population beyond z = 11 or that galaxies have faded by that redshift.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 434; 1; p. 114-127
    Format: text
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  • 4
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    Hawaii 167: A compact absorption-line object at z = 2.35 (1994)
    In:  Other Sources
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    Publication Date: 2019-08-27
    Description: During the course of the Hawaii K-band (2.1 micrometer) survey we have detected a compact object, Hawaii 167, lying at a redshift of 2.33, in which are seen both low- and high-ionization absorption lines. In the near-infrared we see broad H alpha emission at a redshift of 2.35 but do not detect the other Balmer lines, (O II) lambda 3727, or (O III) lambda 5007. The absence of strong Mg II or C IV emission in the rest ultraviolet suggests that, at these wavelengths, we may be seeing a poststarburst galaxy rather than a quasar. Indeed, this class of object may be common enough to represent a major episode of galaxy formation, possibly the formation of the spheroids. However, Q0059-2735, the most extreme member of the class of Mg II absorbing broad absorption line quasars, is very similar to the present object, and there may be an evolutionary sequence or some other close connection between Hawaii 167 and the broad absorption line quasars.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 432; 2; p. L83-L86
    Format: text
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    NASA TECHNICAL REPORTS
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