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  • 1
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    Wavelength-tunable and shape-reconfigurable photonic capsule resonators containing cholesteric liquid crystals (2018)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2018-06-23
    Description: Cholesteric liquid crystals (CLCs) have a photonic bandgap due to the periodic change of refractive index along their helical axes. The CLCs containing optical gain have served as band-edge lasing resonators. In particular, CLCs in a granular format provide omnidirectional lasing, which are promising as a point light source. However, there is no platform that simultaneously achieves high stability in air and wavelength tunability. We encapsulate CLCs with double shells to design a capsule-type laser resonator. The fluidic CLCs are fully enclosed by an aqueous inner shell that promotes the planar alignment of LC molecules along the interface. The outer shell made of silicone elastomer protects the CLC core and the inner shell from the surroundings. Therefore, the helical axes of the CLCs are radially oriented within the capsules, which provide a stable omnidirectional lasing in the air. At the same time, the fluidic CLCs enable the fine-tuning of lasing wavelength with temperature. The capsules retain their double-shell structure during the dynamic deformation. Therefore, the CLCs in the core maintain the planar alignment along the deformed interface, and a lasing direction can be varied from omnidirectional to bi- or multidirectional, depending on the shape of deformed capsules.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Miniaturized, light-adaptive, wireless dosimeters autonomously monitor exposure to electromagnetic radiation (2019)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2019
    Description: 〈p〉Exposure to electromagnetic radiation (EMR) from the sun and from artificial lighting systems represents a modifiable risk factor for a broad range of health conditions including skin cancer, skin aging, sleep and mood disorders, and retinal damage. Technologies for personalized EMR dosimetry could guide lifestyles toward behaviors that ensure healthy levels of exposure. Here, we report a millimeter-scale, ultralow-power digital dosimeter platform that provides continuous EMR dosimetry in an autonomous mode at one or multiple wavelengths simultaneously, with time-managed wireless, long-range communication to standard consumer devices. A single, small button cell battery supports a multiyear life span, enabled by the combined use of a light-powered, accumulation mode of detection and a light-adaptive, ultralow-power circuit design. Field studies demonstrate single- and multimodal dosimetry platforms of this type, with a focus on monitoring short-wavelength blue light from indoor lighting and display systems and ultraviolet/visible/infrared radiation from the sun.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    ATG7 maintains acinar cell function [Cell Biology] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-11-11
    Description: Pancreatic acinar cells possess very high protein synthetic rates as they need to produce and secrete large amounts of digestive enzymes. Acinar cell damage and dysfunction cause malnutrition and pancreatitis, and inflammation of the exocrine pancreas that promotes development of pancreatic ductal adenocarcinoma (PDAC), a deadly pancreatic neoplasm. The cellular...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
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    High-intensity laser-accelerated ion beam produced from cryogenic micro-jet target (2016)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2016-08-25
    Description: We report on the successful operation of a newly developed cryogenic jet target at high intensity laser-irradiation. Using the frequency-doubled Titan short pulse laser system at Jupiter Laser Facility, Lawrence Livermore National Laboratory, we demonstrate the generation of a pure proton beam a with maximum energy of 2 MeV. Furthermore, we record a quasi-monoenergetic peak at 1.1 MeV in the proton spectrum emitted in the laser forward direction suggesting an alternative acceleration mechanism. Using a solid-density mixed hydrogen-deuterium target, we are also able to produce pure proton-deuteron ion beams. With its high purity, limited size, near-critical density, and high-repetition rate capability, this target is promising for future applications.
    Print ISSN: 0034-6748
    Electronic ISSN: 1089-7623
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Published by American Institute of Physics (AIP)
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  • 5
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    Development of a cryogenic hydrogen microjet for high-intensity, high-repetition rate experiments (2016)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2016-08-20
    Description: The advent of high-intensity, high-repetition-rate lasers has led to the need for replenishing targets of interest for high energy density sciences. We describe the design and characterization of a cryogenic microjet source, which can deliver a continuous stream of liquid hydrogen with a diameter of a few microns. The jet has been imaged at 1 μ m resolution by shadowgraphy with a short pulse laser. The pointing stability has been measured at well below a mrad, for a stable free-standing filament of solid-density hydrogen.
    Print ISSN: 0034-6748
    Electronic ISSN: 1089-7623
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Published by American Institute of Physics (AIP)
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  • 6
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    The Mechanisms of Earthquakes and Faulting in the Southern Gulf of California (2013)
    Seismological Society of America (SSA)
    Details
    Publication Date: 2013-02-07
    Description: Accurate earthquake locations and their focal mechanisms can illuminate the distribution and mode of deformation at rifted continental margins. The Pacific–North America (Pa–NA) plate boundary within the Gulf of California (GoC) provides an excellent opportunity to explore the evolution and kinematics of rifting, as continental extension in the north transitions to seafloor spreading in the south. From October 2005 to October 2006, an array of eight four-component ocean-bottom seismographs deployed in the GoC recorded seismicity as part of the Sea of Cortez Ocean-Bottom Array (SCOOBA) experiment. By combining the data with those from the onshore Network of Autonomously Recording Seismographs (NARS)-Baja array, we detect and locate ~700 earthquakes ( M w  2.2–6.6) mainly along the northwest–southeast-striking transform faults that delineate the plate boundary. For 36 events ( M w  3.5–6.6) with high signal-to-noise ratio in a long-period (10–20 s) band, we determine deviatoric moment tensors and associated double-couple focal mechanisms by regional waveform inversion. Many focal mechanisms are consistent with right-lateral strike-slip faulting along the Pa–NA transform fault system, which suggests that the transform faults primarily accommodate seismic deformation within the gulf. In addition, we capture a swarm of events on Baja California along the right-lateral northwest–southeast-striking Las Viboras–El Azufre fault, which may be related to ongoing geothermal activity and volcanic deformation within the peninsula. The combination of high-resolution earthquake locations and focal mechanisms improves our understanding of the distribution of seismic deformation within the greater extensional zone in the southern GoC. Online Material: Earthquake catalog of the 695 events detected and located during our combined on-/offshore deployment of seismometers.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
    Published by Seismological Society of America (SSA)
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  • 7
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    Heterogeneous to homogeneous melting transition visualized with ultrafast electron diffraction (2018)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2018-06-29
    Description: The ultrafast laser excitation of matters leads to nonequilibrium states with complex solid-liquid phase-transition dynamics. We used electron diffraction at mega–electron volt energies to visualize the ultrafast melting of gold on the atomic scale length. For energy densities approaching the irreversible melting regime, we first observed heterogeneous melting on time scales of 100 to 1000 picoseconds, transitioning to homogeneous melting that occurs catastrophically within 10 to 20 picoseconds at higher energy densities. We showed evidence for the heterogeneous coexistence of solid and liquid. We determined the ion and electron temperature evolution and found superheated conditions. Our results constrain the electron-ion coupling rate, determine the Debye temperature, and reveal the melting sensitivity to nucleation seeds.
    Keywords: Physics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-07-03
    Description: Reprogramming of somatic cells is a valuable tool to understand the mechanisms of regaining pluripotency and further opens up the possibility of generating patient-specific pluripotent stem cells. Reprogramming of mouse and human somatic cells into pluripotent stem cells, designated as induced pluripotent stem (iPS) cells, has been possible with the expression of the transcription factor quartet Oct4 (also known as Pou5f1), Sox2, c-Myc and Klf4 (refs 1-11). Considering that ectopic expression of c-Myc causes tumorigenicity in offspring and that retroviruses themselves can cause insertional mutagenesis, the generation of iPS cells with a minimal number of factors may hasten the clinical application of this approach. Here we show that adult mouse neural stem cells express higher endogenous levels of Sox2 and c-Myc than embryonic stem cells, and that exogenous Oct4 together with either Klf4 or c-Myc is sufficient to generate iPS cells from neural stem cells. These two-factor iPS cells are similar to embryonic stem cells at the molecular level, contribute to development of the germ line, and form chimaeras. We propose that, in inducing pluripotency, the number of reprogramming factors can be reduced when using somatic cells that endogenously express appropriate levels of complementing factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Jeong Beom -- Zaehres, Holm -- Wu, Guangming -- Gentile, Luca -- Ko, Kinarm -- Sebastiano, Vittorio -- Arauzo-Bravo, Marcos J -- Ruau, David -- Han, Dong Wook -- Zenke, Martin -- Scholer, Hans R -- England -- Nature. 2008 Jul 31;454(7204):646-50. doi: 10.1038/nature07061. Epub 2008 Jun 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Rontgenstrasse 20, 48149 Munster, NRW, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18594515" target="_blank"〉PubMed〈/a〉
    Keywords: Adult Stem Cells/*cytology/metabolism ; Animals ; Cell Differentiation/genetics ; Cells, Cultured ; *Cellular Reprogramming ; Chimera ; DNA-Binding Proteins/genetics/metabolism ; Female ; Gene Expression Profiling ; Genes, myc/genetics ; HMGB Proteins/genetics/metabolism ; Homeodomain Proteins/genetics ; Kruppel-Like Transcription Factors/genetics/metabolism ; Male ; Mice ; Mice, Nude ; Mice, Transgenic ; Neurons/*cytology ; Octamer Transcription Factor-3/genetics/metabolism ; Pluripotent Stem Cells/*cytology/*metabolism ; Proteins/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; RNA, Untranslated ; SOXB1 Transcription Factors ; Transcription Factors/genetics/metabolism ; Transduction, Genetic
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 9
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    Direct reprogramming of human neural stem cells by OCT4 (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-09-01
    Description: Induced pluripotent stem (iPS) cells have been generated from mouse and human somatic cells by ectopic expression of four transcription factors (OCT4 (also called POU5F1), SOX2, c-Myc and KLF4). We previously reported that Oct4 alone is sufficient to reprogram directly adult mouse neural stem cells to iPS cells. Here we report the generation of one-factor human iPS cells from human fetal neural stem cells (one-factor (1F) human NiPS cells) by ectopic expression of OCT4 alone. One-factor human NiPS cells resemble human embryonic stem cells in global gene expression profiles, epigenetic status, as well as pluripotency in vitro and in vivo. These findings demonstrate that the transcription factor OCT4 is sufficient to reprogram human neural stem cells to pluripotency. One-factor iPS cell generation will advance the field further towards understanding reprogramming and generating patient-specific pluripotent stem cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Jeong Beom -- Greber, Boris -- Arauzo-Bravo, Marcos J -- Meyer, Johann -- Park, Kook In -- Zaehres, Holm -- Scholer, Hans R -- England -- Nature. 2009 Oct 1;461(7264):649-3. doi: 10.1038/nature08436.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology, Rontgenstrasse 20, 48149 Munster, NRW, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19718018" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomarkers/analysis ; *Cell Dedifferentiation ; Cell Differentiation ; Cell Line ; *Cellular Reprogramming ; DNA Methylation ; Embryonic Stem Cells/cytology/metabolism ; Epigenesis, Genetic ; Fetus/*cytology ; Gene Expression Profiling ; Germ Layers/cytology/metabolism ; Humans ; Mice ; Neurons/*cytology/metabolism ; Octamer Transcription Factor-3/genetics/*metabolism ; Pluripotent Stem Cells/*cytology/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 10
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    Endochondral ossification is required for haematopoietic stem-cell niche formation (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-12-17
    Description: Little is known about the formation of niches, local micro-environments required for stem-cell maintenance. Here we develop an in vivo assay for adult haematopoietic stem-cell (HSC) niche formation. With this assay, we identified a population of progenitor cells with surface markers CD45(-)Tie2(-)alpha(V)(+)CD105(+)Thy1.1(-) (CD105(+)Thy1(-)) that, when sorted from 15.5 days post-coitum fetal bones and transplanted under the adult mouse kidney capsule, could recruit host-derived blood vessels, produce donor-derived ectopic bones through a cartilage intermediate and generate a marrow cavity populated by host-derived long-term reconstituting HSC (LT-HSC). In contrast, CD45(-)Tie2(-)alpha(V)(+)CD105(+)Thy1(+) (CD105(+)Thy1(+)) fetal bone progenitors form bone that does not contain a marrow cavity. Suppressing expression of factors involved in endochondral ossification, such as osterix and vascular endothelial growth factor (VEGF), inhibited niche generation. CD105(+)Thy1(-) progenitor populations derived from regions of the fetal mandible or calvaria that do not undergo endochondral ossification formed only bone without marrow in our assay. Collectively, our data implicate endochondral ossification, bone formation that proceeds through a cartilage intermediate, as a requirement for adult HSC niche formation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648141/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648141/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, Charles K F -- Chen, Ching-Cheng -- Luppen, Cynthia A -- Kim, Jae-Beom -- DeBoer, Anthony T -- Wei, Kevin -- Helms, Jill A -- Kuo, Calvin J -- Kraft, Daniel L -- Weissman, Irving L -- 1R01HL074267-01/HL/NHLBI NIH HHS/ -- 1R01NS052830-01/NS/NINDS NIH HHS/ -- 2R01HL058770-08/HL/NHLBI NIH HHS/ -- 5K99HL087936-02/HL/NHLBI NIH HHS/ -- 5R01CA086065-09/CA/NCI NIH HHS/ -- K08-HL076335/HL/NHLBI NIH HHS/ -- K99 HL087936/HL/NHLBI NIH HHS/ -- K99 HL087936-01/HL/NHLBI NIH HHS/ -- K99 HL087936-02/HL/NHLBI NIH HHS/ -- R00 HL087936/HL/NHLBI NIH HHS/ -- R00 HL087936-03/HL/NHLBI NIH HHS/ -- R00 HL087936-04/HL/NHLBI NIH HHS/ -- R00 HL087936-05/HL/NHLBI NIH HHS/ -- R01 CA086065/CA/NCI NIH HHS/ -- R01 CA086065-09/CA/NCI NIH HHS/ -- R01 HL058770/HL/NHLBI NIH HHS/ -- R01 HL058770-08/HL/NHLBI NIH HHS/ -- England -- Nature. 2009 Jan 22;457(7228):490-4. doi: 10.1038/nature07547. Epub 2008 Dec 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA. chazchan@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19078959" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD/metabolism ; Antigens, Thy-1/metabolism ; Cartilage/*cytology/embryology ; Choristoma ; Fetus/cytology ; Hematopoietic Stem Cells/*cytology/metabolism ; Mandible/cytology/embryology ; Mice ; Mice, Inbred C57BL ; Osteogenesis/*physiology ; Skull/cytology/embryology ; Stem Cell Niche/*cytology/*physiology ; Transcription Factors/antagonists & inhibitors/metabolism ; Vascular Endothelial Growth Factor A/antagonists & inhibitors/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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