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  • 1
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    Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate (2008)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2008-05-30
    Beschreibung: As alterations in tissue pH underlie many pathological processes, the capability to image tissue pH in the clinic could offer new ways of detecting disease and response to treatment. Dynamic nuclear polarization is an emerging technique for substantially increasing the sensitivity of magnetic resonance imaging experiments. Here we show that tissue pH can be imaged in vivo from the ratio of the signal intensities of hyperpolarized bicarbonate (H(13)CO(3)(-)) and (13)CO(2) following intravenous injection of hyperpolarized H(13)CO(3)(-). The technique was demonstrated in a mouse tumour model, which showed that the average tumour interstitial pH was significantly lower than the surrounding tissue. Given that bicarbonate is an endogenous molecule that can be infused in relatively high concentrations into patients, we propose that this technique could be used clinically to image pathological processes that are associated with alterations in tissue pH, such as cancer, ischaemia and inflammation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallagher, Ferdia A -- Kettunen, Mikko I -- Day, Sam E -- Hu, De-En -- Ardenkjaer-Larsen, Jan Henrik -- Zandt, Rene in 't -- Jensen, Pernille R -- Karlsson, Magnus -- Golman, Klaes -- Lerche, Mathilde H -- Brindle, Kevin M -- C197/A3514/Cancer Research UK/United Kingdom -- England -- Nature. 2008 Jun 12;453(7197):940-3. doi: 10.1038/nature07017. Epub 2008 May 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18509335" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acid-Base Equilibrium ; Animals ; Bicarbonates/*metabolism ; Carbon Dioxide/metabolism ; Carbon Isotopes ; Carbonic Anhydrases/metabolism ; Catalysis ; Hydrogen-Ion Concentration ; Lymphoma/*diagnosis/*metabolism/pathology ; Magnetic Resonance Imaging/*methods ; Mice ; Neoplasm Transplantation ; Phantoms, Imaging
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1996-12-20
    Beschreibung: Adipocyte differentiation is an important component of obesity and other metabolic diseases. This process is strongly inhibited by many mitogens and oncogenes. Several growth factors that inhibit fat cell differentiation caused mitogen-activated protein (MAP) kinase-mediated phosphorylation of the dominant adipogenic transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) and reduction of its transcriptional activity. Expression of PPARgamma with a nonphosphorylatable mutation at this site (serine-112) yielded cells with increased sensitivity to ligand-induced adipogenesis and resistance to inhibition of differentiation by mitogens. These results indicate that covalent modification of PPARgamma by serum and growth factors is a major regulator of the balance between cell growth and differentiation in the adipose cell lineage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hu, E -- Kim, J B -- Sarraf, P -- Spiegelman, B M -- R37DK31405/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1996 Dec 20;274(5295):2100-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8953045" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 3T3 Cells ; Adipocytes/*cytology/metabolism ; Animals ; Blood ; Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors/*metabolism ; Cell Differentiation ; Cell Line ; Enzyme Inhibitors/pharmacology ; Epidermal Growth Factor/pharmacology ; Flavonoids/pharmacology ; Insulin/pharmacology ; Ligands ; Mice ; Mitogens/pharmacology ; Mutation ; Phosphorylation ; Rats ; Receptors, Cytoplasmic and Nuclear/chemistry/genetics/*metabolism ; Tetradecanoylphorbol Acetate/pharmacology ; Transcription Factors/chemistry/genetics/*metabolism ; Transcription, Genetic/drug effects ; Transfection
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Were small galaxies once the dominant cosmological population? (1991)
    In:  Other Sources
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    Publikationsdatum: 2011-08-24
    Beschreibung: Redshifts and K magnitudes have been obtained for a small but complete sample of 22 galaxies with B magnitudes down to 24. In the luminosity range B = 23-24, the B-band galaxy counts are dominated by a population of small blue galaxies at z roughly 0.25, which may collectively contain as much baryonic matter as the normal galaxies. It is possible either that these earlier galaxies have undergone merging to create the present galaxy population, or that they represent a quite different galactic population which has now faded or disappeared. Either possibility has considerable implications for understanding of galaxy formation.
    Schlagwort(e): ASTROPHYSICS
    Materialart: Nature (ISSN 0028-0836); 354; 460
    Format: text
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  • 4
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    The filaments of NGC 1275 - A collision between a galaxy and an accretion flow? (1983)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-28
    Beschreibung: Morphological evidence is presented (in the form of 3-A-bandpass Fabry-Perot images made with a CCD camera) that the two bright emission-line systems seen toward the galaxy NGC 1275 arise from a high-velocity impact of a foreground galaxy upon the accretion flow of gas cooling in the center of the Perseus cluster. The uniquely high optical-line luminosity of NGC 1275, in comparison with other central galaxies in clusters observed to have cooling flows, may be explained by energy deposited during the collision. Using additional information from 21-cm and extinction measurements, a rough model of the interaction is developed. Problems remain with this model - such as the likelihood of a gas-rich system penetrating to the cluster center. The kinematic structure of the optically emitting gas shows additional complex structure near the nucleus of NGC 1275.
    Schlagwort(e): ASTROPHYSICS
    Materialart: Astrophysical Journal, Part 2 - Letters to the Editor (ISSN 0004-637X); 275; L27-L31
    Format: text
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  • 5
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    The Gemini-Monoceros X-ray enhancement - A giant X-ray ring (1981)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-28
    Beschreibung: A 1.5 deg spatial resolution map of the 1/4 KeV diffuse X-ray background enhancement in the Gemini and Monoceros constellations is found to show a circular ring-shaped emission feature with a diameter of 20 deg. The feature and possible X-ray contributions from the Mon OB1 association and neighboring supernova remnants are discussed. From 300 pc, the region has a radius of 50 pc, with an emitting electron density of 0.01 per cu cm. A shell of expanding neutral hydrogen and nonthermal radio spur is observed outside the ring with the X-ray emitting pulsar PSR 0656 + 14 lying close to the center of the ring. Origins of the ring are discussed, ruling out formation by the association Mon OB1. The ring is considered to be a field supernova remnant formed by the progenitor of the central pulsar, and providing constraints on theories of remnant evolution. This conclusion is found to agree with estimated supernova rates, and the absence of additional examples of this stage of evolution is an observational selection effect.
    Schlagwort(e): ASTROPHYSICS
    Materialart: Astrophysical Journal; vol. 248
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    High latitude H I shells in the Galaxy. I (1981)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-28
    Beschreibung: A search has been made for H I shells in the 21-cm maps made by Heiles and Habing (1974) for absolute values of galactic latitude greater than 10 deg. A filter in the velocity dimension was used to enhance shell features over background gas. Positions, expansion velocities, column densities, and angular extents were measured for the 50 shells that were discovered. Incorporating distance estimates, masses and kinetic energies were estimated for the shells. A striking result was the failure of swept-up matter in a standard model for gas in the disk (density at the midplane approximately 1/cu cm; exponential scale height approximately 130 pc) to reproduce the observed shell column densities. While measured shell densities may be insufficiently corrected for background gas, the magnitude of this effect is too large to be explained by such a discrepancy alone. This may suggest that the shells seen in this survey occur in regions of relatively high density. The distribution of H I shells was compared with the distribution of other large-scale features in the Galaxy: H I shell structures are found to correlate with the positions of radio continuum loops I, II, and III, and to show little relation to the distribution of O and B stars.
    Schlagwort(e): ASTROPHYSICS
    Materialart: Astrophysical Journal; vol. 248
    Format: text
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  • 7
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    A search for expanding supershells of gas around OB associations (1981)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-28
    Beschreibung: The results of a search for giant, rapidly expanding shells of gas surrounding OB associations are recorded. Two out of thirteen nearby associations (Orion and Carina) show supershells of gas with radii of about 100 pc, expansion velocities of about 100 km/sec, and ages of about 400,000 years. Observations of the newly discovered Carina supershell are presented. It is suggested that these features are formed by supernova explosions in the associations. The birthrate of association supernovae than lies between 1.5 x 10 to the -14th/cu pc per/year and 10 to the -13th/cu pc per/year.
    Schlagwort(e): ASTROPHYSICS
    Materialart: Astrophysical Journal; vol. 250
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
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    The distribution and morphology of X-ray-emitting gas in the core of the Perseus cluster (1981)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-28
    Beschreibung: An unresolved source has been found coincident with the nucleus of NGC 1275 in a high-resolution X-ray image of the core of the Perseus cluster. Absorption in the optical features at high velocity with respect to NGC 1275, which are thought to be associated with a foreground galaxy, does not produce any detectable X-ray absorption. The emission tends to become asymmetric in the presence of the lower-velocity filaments, but no obvious, detailed correlation is found between X-ray enhancements and individual filaments. Deprojection of surface brightness to yield temperature and density profiles of the intracluster gas shows results consistent with a quasi-hydrostatic radiative accretion flow onto NGC 1275, and the pressure-driven mass inflow onto the central galaxy is then 200-400 solar masses/yr. The possibility of a problem in the relation of line-of-sight velocity dispersion to cluster gravitational mass is confirmed.
    Schlagwort(e): ASTROPHYSICS
    Materialart: Astrophysical Journal; vol. 248
    Format: text
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  • 9
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    Two-dimensional spectrophotometry of the cores of X-ray luminous clusters (1983)
    In:  Other Sources
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    Publikationsdatum: 2019-06-28
    Beschreibung: The results of a two-dimensional spectrophotometric survey of the core regions of 11 rich clusters of galaxies are presented. A number of these clusters have spectacular optical emission line systems in their cores. Both morphologically and kinematically, the emission line regions divide into extended, 20-100 kpc systems of long linear filaments associated with the cluster core and more compact, homogeneous elongated regions associated with the dominant central cluster galaxy. It is suggested that the present results can be expected, as hot X-ray emitting gas cools in the cluster center. Luminosities almost entirely agree with expected values. The morphology of the systems can be understood if the filaments form initially in the cooling flow and, in some cases, are subsequently accreted by the central galaxy.
    Schlagwort(e): ASTROPHYSICS
    Materialart: Astrophysical Journal, Part 1 (ISSN 0004-637X); 272; Sept. 1
    Format: text
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  • 10
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    Interstellar absorption lines toward gamma Arae (1975)
    In:  Other Sources
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    Publikationsdatum: 2019-06-27
    Beschreibung: The available data on interstellar absorption lines in the spectrum of gamma Ara observed from the ground and with the Copernicus telescope have been analyzed to give column densities of various ion stages of H, C, N, O, Na, Mg, Si, P, S, Ar, Ca, Mn, and Fe. The element abundances with respect to H nuclei in H I regions are similar to the values for zeta Oph, with depletions relative to the sun tending to increase with increasing condensation temperature. For example, toward gamma Ara, Fe is depleted by a factor of 50; Mg, Si, and Mn by about 10; and S, P, and N little or none. Interstellar Si IV and probably S IV appear stronger than in most other stars, but still their low ratios to Si III and S III suggest that soft X-rays and low-energy cosmic rays are not important sources of ionization. The width of the O VI lines and the absence of N V have been interpreted as evidence for a collisionally ionized region with a temperature between 300,000 and 700,000 K containing at least 0.0004 of the total interstellar column density.
    Schlagwort(e): ASTROPHYSICS
    Materialart: Astrophysical Journal; 202; Dec. 15
    Format: text
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