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  • SOCAT; Surface Ocean CO2 Atlas Project  (4)
  • *Seawater  (1)
  • Anoxia/*metabolism/pathology
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  • 1
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    Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-06-13
    Description: Osteoclasts are multinucleated haematopoietic cells that resorb bone. Increased osteoclast activity causes osteoporosis, a disorder resulting in a low bone mass and a high risk of fractures. Increased osteoclast size and numbers are also a hallmark of other disorders, such as Paget's disease and multiple myeloma. The protein c-Fos, a component of the AP-1 transcription factor complex, is essential for osteoclast differentiation. Here we show that the Fos-related protein Fra-2 controls osteoclast survival and size. The bones of Fra-2-deficient newborn mice have giant osteoclasts, and signalling through leukaemia inhibitory factor (LIF) and its receptor is impaired. Similarly, newborn animals lacking LIF have giant osteoclasts, and we show that LIF is a direct transcriptional target of Fra-2 and c-Jun. Moreover, bones deficient in Fra-2 and LIF are hypoxic and express increased levels of hypoxia-induced factor 1alpha (HIF1alpha) and Bcl-2. Overexpression of Bcl-2 is sufficient to induce giant osteoclasts in vivo, whereas Fra-2 and LIF affect HIF1alpha through transcriptional modulation of the HIF prolyl hydroxylase PHD2. This pathway is operative in the placenta, because specific inactivation of Fra-2 in the embryo alone does not cause hypoxia or the giant osteoclast phenotype. Thus placenta-induced hypoxia during embryogenesis leads to the formation of giant osteoclasts in young pups. These findings offer potential targets for the treatment of syndromes associated with increased osteoclastogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bozec, Aline -- Bakiri, Latifa -- Hoebertz, Astrid -- Eferl, Robert -- Schilling, Arndt F -- Komnenovic, Vukoslav -- Scheuch, Harald -- Priemel, Matthias -- Stewart, Colin L -- Amling, Michael -- Wagner, Erwin F -- England -- Nature. 2008 Jul 10;454(7201):221-5. doi: 10.1038/nature07019. Epub 2008 Jun 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18548006" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Anoxia/*metabolism/pathology ; Bone and Bones/cytology/metabolism/pathology ; *Cell Size ; Cell Survival ; DNA-Binding Proteins/metabolism ; Female ; Fos-Related Antigen-2/deficiency/genetics/*metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Hypoxia-Inducible Factor-Proline Dioxygenases ; Immediate-Early Proteins/metabolism ; Leukemia Inhibitory Factor/deficiency/genetics/*metabolism ; Leukemia Inhibitory Factor Receptor alpha Subunit/*metabolism ; Male ; Mice ; Osteoclasts/*cytology/metabolism/pathology ; Procollagen-Proline Dioxygenase ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-bcl-2 ; *Signal Transduction
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Enhanced open ocean storage of CO2 from shelf sea pumping (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-05-15
    Description: Seasonal field observations show that the North Sea, a Northern European shelf sea, is highly efficient in pumping carbon dioxide from the atmosphere to the North Atlantic Ocean. The bottom topography-controlled stratification separates production and respiration processes in the North Sea, causing a carbon dioxide increase in the subsurface layer that is ultimately exported to the North Atlantic Ocean. Globally extrapolated, the net uptake of carbon dioxide by coastal and marginal seas is about 20% of the world ocean's uptake of anthropogenic carbon dioxide, thus enhancing substantially the open ocean carbon dioxide storage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thomas, Helmuth -- Bozec, Yann -- Elkalay, Khalid -- de Baar, Hein J W -- New York, N.Y. -- Science. 2004 May 14;304(5673):1005-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department for Marine Chemistry and Geology, Royal Netherlands Institute for Sea Research, Post Office Box 59, NL-1790 AB Den Burg, Texel, Netherlands. hthomas@nioz.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15143279" target="_blank"〉PubMed〈/a〉
    Keywords: *Atmosphere ; Carbon Dioxide/*analysis/metabolism ; *Food Chain ; North Sea ; Seasons ; *Seawater
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Surface Ocean CO2 Atlas (SOCAT) V4 (2016)
    PANGAEA
    Details
    Publication Date: 2024-05-02
    Description: The Surface Ocean CO2 Atlas (SOCAT) is a synthesis activity by the international marine carbon research community (〉100 contributors). SOCAT version 4 has 18.5 million quality-controlled, surface ocean fCO2 (fugacity of carbon dioxide) observations with an accuracy of better than 5 µatm from 1957 to 2015 for the global oceans and coastal seas. Automation of data upload and initial data checks speeds up data submission and allows annual releases of SOCAT from version 4 onwards. SOCAT enables quantification of the ocean carbon sink and ocean acidification and evaluation of ocean biogeochemical models. SOCAT represents a milestone in research coordination, data access, biogeochemical and climate research and in informing policy.
    Keywords: SOCAT; Surface Ocean CO2 Atlas Project
    Type: Dataset
    Format: application/zip, 1265 datasets
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  • 4
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    Surface Ocean CO2 Atlas (SOCAT) V2 (2014)
    PANGAEA
    In:  Supplement to: Bakker, Dorothee C E; Pfeil, Benjamin; Smith, Karl; Hankin, Steven; Olsen, Are; Alin, Simone R; Cosca, Catherine E; Harasawa, Sumiko; Kozyr, Alexander; Nojiri, Yukihiro; O'Brien, Kevin M; Schuster, Ute; Telszewski, Maciej; Tilbrook, Bronte; Wada, Chisato; Akl, John; Barbero, Leticia; Bates, Nicolas R; Boutin, Jacqueline; Bozec, Yann; Cai, Wei-Jun; Castle, Robert D; Chavez, Francisco P; Chen, Lei; Chierici, Melissa; Currie, Kim I; de Baar, Hein J W; Evans, Wiley; Feely, Richard A; Fransson, Agneta; Gao, Zhongyong; Hales, Burke; Hardman-Mountford, Nicolas J; Hoppema, Mario; Huang, Wei-Jen; Hunt, Christopher W; Huss, Betty; Ichikawa, Tadafumi; Johannessen, Truls; Jones, Elizabeth M; Jones, Steve D; Jutterstrøm, Sara; Kitidis, Vassilis; Körtzinger, Arne; Landschützer, Peter; Lauvset, Siv K; Lefèvre, Nathalie; Manke, Ansley; Mathis, Jeremy T; Merlivat, Liliane; Metzl, Nicolas; Murata, Akihiko; Newberger, Timothy; Omar, Abdirahman M; Ono, Tsuneo; Park, Geun-Ha; Paterson, Kristina; Pierrot, Denis; Ríos, Aida F; Sabine, Christopher L; Saito, Shu; Salisbury, Joe; Sarma, Vedula V S S; Schlitzer, Reiner; Sieger, Rainer; Skjelvan, Ingunn; Steinhoff, Tobias; Sullivan, Kevin; Sun, Heng; Sutton, Adrienne; Suzuki, Toru; Sweeney, Colm; Takahashi, Taro; Tjiputra, Jerry; Tsurushima, Nobuo; van Heuven, Steven; Vandemark, Doug; Vlahos, Penny; Wallace, Douglas WR; Wanninkhof, Rik; Watson, Andrew J (2014): An update to the Surface Ocean CO2 Atlas (SOCAT version 2). Earth System Science Data, 6(1), 69-90, https://doi.org/10.5194/essd-6-69-2014
    Details
    Publication Date: 2024-05-02
    Description: The Surface Ocean CO2 Atlas (SOCAT), an activity of the international marine carbon research community, provides access to synthesis and gridded fCO2 (fugacity of carbon dioxide) products for the surface oceans. Version 2 of SOCAT is an update of the previous release (version 1) with more data (increased from 6.3 million to 10.1 million surface water fCO2 values) and extended data coverage (from 1968-2007 to 1968-2011). The quality control criteria, while identical in both versions, have been applied more strictly in version 2 than in version 1. The SOCAT website (http://www.socat.info/) has links to quality control comments, metadata, individual data set files, and synthesis and gridded data products. Interactive online tools allow visitors to explore the richness of the data. Applications of SOCAT include process studies, quantification of the ocean carbon sink and its spatial, seasonal, year-to-year and longerterm variation, as well as initialisation or validation of ocean carbon models and coupled climate-carbon models.
    Keywords: SOCAT; Surface Ocean CO2 Atlas Project
    Type: Dataset
    Format: application/zip, 2669 datasets
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  • 5
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    Surface Ocean CO2 Atlas (SOCAT) V3 (2016)
    PANGAEA
    In:  Supplement to: Bakker, Dorothee C E; Pfeil, Benjamin; Landa, Camilla S; Metzl, Nicolas; O'Brien, Kevin M; Olsen, Are; Smith, Karl; Cosca, Catherine E; Harasawa, Sumiko; Jones, Steve D; Nakaoka, Shin-Ichiro; Nojiri, Yukihiro; Schuster, Ute; Steinhoff, Tobias; Sweeney, Colm; Takahashi, Taro; Tilbrook, Bronte; Wada, Chisato; Wanninkhof, Rik; Alin, Simone R; Balestrini, Carlos F; Barbero, Leticia; Bates, Nicolas R; Bianchi, Alejandro A; Bonou, Frédéric Kpédonou; Boutin, Jacqueline; Bozec, Yann; Burger, Eugene; Cai, Wei-Jun; Castle, Robert D; Chen, Liqi; Chierici, Melissa; Currie, Kim I; Evans, Wiley; Featherstone, Charles; Feely, Richard A; Fransson, Agneta; Goyet, Catherine; Greenwood, Naomi; Gregor, Luke; Hankin, Steven; Hardman-Mountford, Nicolas J; Harlay, Jérôme; Hauck, Judith; Hoppema, Mario; Humphreys, Matthew P; Hunt, Christopher W; Huss, Betty; Ibánhez, J Severino P; Johannessen, Truls; Keeling, Ralph F; Kitidis, Vassilis; Körtzinger, Arne; Kozyr, Alexander; Krasakopoulou, Evangelia; Kuwata, Akira; Landschützer, Peter; Lauvset, Siv K; Lefèvre, Nathalie; Lo Monaco, Claire; Manke, Ansley; Mathis, Jeremy T; Merlivat, Liliane; Millero, Frank J; Monteiro, Pedro M S; Munro, David R; Murata, Akihiko; Newberger, Timothy; Omar, Abdirahman M; Ono, Tsuneo; Paterson, Kristina; Pearce, David J; Pierrot, Denis; Robbins, Lisa L; Saito, Shu; Salisbury, Joe; Schlitzer, Reiner; Schneider, Bernd; Schweitzer, Roland; Sieger, Rainer; Skjelvan, Ingunn; Sullivan, Kevin; Sutherland, Stewart C; Sutton, Adrienne; Tadokoro, Kazuaki; Telszewski, Maciej; Tuma, Matthias; van Heuven, Steven; Vandemark, Doug; Ward, Brian; Watson, Andrew J; Xu, Suqing (2016): A multi-decade record of high-quality fCO2 data in version 3 of the Surface Ocean CO2 Atlas (SOCAT). Earth System Science Data, 8(2), 383-413, https://doi.org/10.5194/essd-8-383-2016
    Details
    Publication Date: 2024-05-02
    Description: The Surface Ocean CO2 Atlas (SOCAT) is a synthesis of quality-controlled fCO2 (fugacity of carbon dioxide) values for the global surface oceans and coastal seas with regular updates. Version 3 of SOCAT has 14.5 million fCO2 values from 3646 data sets covering the years 1957 to 2014. This latest version has an additional 4.4 million fCO2 values relative to version 2 and extends the record from 2011 to 2014. Version 3 also significantly increases the data availability for 2005 to 2013. SOCAT has an average of approximately 1.2 million surface water fCO2 values per year for the years 2006 to 2012. Quality and documentation of the data has improved. A new feature is the data set quality control (QC) flag of E for data from alternative sensors and platforms. The accuracy of surface water fCO2 has been defined for all data set QC flags. Automated range checking has been carried out for all data sets during their upload into SOCAT. The upgrade of the interactive Data Set Viewer allows better interrogation of the SOCAT data collection and rapid creation of high-quality figures for scientific presentations. Automated data upload has been launched for version 4 and will enable more frequent SOCAT releases in the future. High-profile scientific applications of SOCAT include quantification of the ocean sink for atmospheric carbon dioxide and its long-term variation, detection of ocean acidification, as well as evaluation of coupled-climate and ocean-only biogeochemical models. Users of SOCAT data products are urged to acknowledge the contribution of data providers, as stated in the SOCAT Fair Data Use Statement. This living data publication documents changes in the methods and data sets used in this new version of the SOCAT data collection compared with previous publications of this data collection (Pfeil et al., 2013; Sabine et al., 2013; Bakker et al., 2014).
    Keywords: SOCAT; Surface Ocean CO2 Atlas Project
    Type: Dataset
    Format: application/zip, 3657 datasets
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  • 6
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    Surface Ocean CO2 Atlas (SOCAT) V6 (2018)
    PANGAEA
    Details
    Publication Date: 2024-05-02
    Description: The Surface Ocean CO2 Atlas (SOCAT) is a synthesis activity by the international marine carbon research community (〉100 contributors). SOCAT version 6 has 23.4 million quality-controlled, surface ocean fCO2 (fugacity of carbon dioxide) observations from 1957 to 2017 for the global oceans and coastal seas. Calibrated sensor data are also available. Automation allows annual, public releases. SOCAT data is discoverable, accessible and citable. SOCAT enables quantification of the ocean carbon sink and ocean acidification and evaluation of ocean biogeochemical models. SOCAT represents a milestone in biogeochemical and climate research and in informing policy.
    Keywords: SOCAT; Surface Ocean CO2 Atlas Project
    Type: Dataset
    Format: application/zip, 424 datasets
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    DATA PANGAEA
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