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  • Polymer and Materials Science  (5)
  • Signal Transduction  (2)
  • rubber  (2)
  • *Mutation  (1)
  • 1
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    LRP: role in vascular wall integrity and protection from atherosclerosis (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-04-12
    Description: Vascular smooth muscle cell (SMC) proliferation and migration are important events in the development of atherosclerosis. The low-density lipoprotein receptor-related protein (LRP1) mediates suppression of SMC migration induced by platelet-derived growth factor (PDGF). Here we show that LRP1 forms a complex with the PDGF receptor (PDGFR). Inactivation of LRP1 in vascular SMCs of mice causes PDGFR overexpression and abnormal activation of PDGFR signaling, resulting in disruption of the elastic layer, SMC proliferation, aneurysm formation, and marked susceptibility to cholesterol-induced atherosclerosis. The development of these abnormalities was reduced by treatment with Gleevec, an inhibitor of PDGF signaling. Thus, LRP1 has a pivotal role in protecting vascular wall integrity and preventing atherosclerosis by controlling PDGFR activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boucher, Philippe -- Gotthardt, Michael -- Li, Wei-Ping -- Anderson, Richard G W -- Herz, Joachim -- GM 52016/GM/NIGMS NIH HHS/ -- HL20948/HL/NHLBI NIH HHS/ -- HL63762/HL/NHLBI NIH HHS/ -- NS43408/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2003 Apr 11;300(5617):329-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9046, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12690199" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta/cytology/metabolism/*pathology ; Arteriosclerosis/*pathology/physiopathology/*prevention & control ; Benzamides ; Cattle ; Cell Division ; Cell Line ; Cholesterol, Dietary/administration & dosage ; Diet, Atherogenic ; Elastin/analysis ; Enzyme Inhibitors/pharmacology ; Imatinib Mesylate ; Ligands ; Low Density Lipoprotein Receptor-Related ; Protein-1/genetics/metabolism/*physiology ; Mesenteric Arteries/cytology/pathology ; Mice ; Mice, Knockout ; Mice, Transgenic ; Muscle, Smooth, Vascular/cytology/*metabolism/pathology ; Myocytes, Smooth Muscle/*metabolism/physiology ; Phosphorylation ; Piperazines/pharmacology ; Platelet-Derived Growth Factor/metabolism/pharmacology ; Proto-Oncogene Proteins c-sis ; Pyrimidines/pharmacology ; Receptor, Platelet-Derived Growth Factor beta/metabolism ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Suppression of aging in mice by the hormone Klotho (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-08-27
    Description: A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending life span. Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by perturbing insulin and IGF1 signaling, suggesting that Klotho-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties. Klotho protein may function as an anti-aging hormone in mammals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536606/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536606/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kurosu, Hiroshi -- Yamamoto, Masaya -- Clark, Jeremy D -- Pastor, Johanne V -- Nandi, Animesh -- Gurnani, Prem -- McGuinness, Owen P -- Chikuda, Hirotaka -- Yamaguchi, Masayuki -- Kawaguchi, Hiroshi -- Shimomura, Iichiro -- Takayama, Yoshiharu -- Herz, Joachim -- Kahn, C Ronald -- Rosenblatt, Kevin P -- Kuro-o, Makoto -- R01 AG019712/AG/NIA NIH HHS/ -- R01 AG019712-05/AG/NIA NIH HHS/ -- R01 AG025326/AG/NIA NIH HHS/ -- R01 AG025326-03/AG/NIA NIH HHS/ -- R01AG19712/AG/NIA NIH HHS/ -- R01AG25326/AG/NIA NIH HHS/ -- R37 HL063762/HL/NHLBI NIH HHS/ -- U24 DK059637/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2005 Sep 16;309(5742):1829-33. Epub 2005 Aug 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Texas (UT) Southwestern Medical Center at Dallas, 5323 Harry Hines Bouleuvard, Dallas, TX 75390-9072, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16123266" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/genetics/*physiology ; Animals ; Blood Glucose/analysis ; Cell Line ; Cell Line, Tumor ; Eating ; Female ; Glucuronidase ; Insulin/blood/metabolism ; Insulin Resistance ; Insulin-Like Growth Factor I/metabolism/pharmacology ; Ligands ; Longevity/genetics/*physiology ; Male ; Membrane Proteins/chemistry/*genetics/pharmacology/*physiology ; Mice ; Mice, Transgenic ; Myoblasts/metabolism ; Oxygen Consumption ; Peptide Fragments/chemistry/pharmacology ; Phosphorylation ; Receptor, IGF Type 1/metabolism ; Receptor, Insulin/metabolism ; Receptors, Cell Surface/metabolism ; Recombinant Proteins/chemistry/isolation & purification/metabolism ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Cancer. A bull's eye for targeted lung cancer therapy (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-06-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Minna, John D -- Gazdar, Adi F -- Sprang, Stephen R -- Herz, Joachim -- P50CA70907/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2004 Jun 4;304(5676):1458-61.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. john.minna@utsouthwestern.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15178790" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/drug therapy/genetics/metabolism ; Amino Acid Substitution ; Antineoplastic Agents/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy/*genetics/metabolism ; Controlled Clinical Trials as Topic ; Enzyme Inhibitors/therapeutic use ; Epidermal Growth Factor/metabolism ; *Genes, erbB-1 ; Humans ; Japan ; Ligands ; Lung Neoplasms/*drug therapy/*genetics/metabolism ; *Mutation ; Phosphorylation ; Protein Structure, Tertiary ; Quinazolines/*therapeutic use ; Receptor, Epidermal Growth Factor/*antagonists & ; inhibitors/chemistry/genetics/metabolism ; Sequence Deletion ; Smoking ; Treatment Outcome ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    Deuterium magnetic resonance on elongated networks: orientational order versus network structure (1987)
    Springer
    Colloid & polymer science 75 (1987), S. 45-48 
    Details
    ISSN: 1435-1536
    Keywords: rubber ; polydimethylsiloxane ; deuterium NMR ; orientational order ; trapped entanglements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The orientational order generated in uniaxially strained (end-linked) polydimethylsiloxane rubbers is investigated as a function of the length of the precursor chains and of the polymer concentration at which the network was formed. The degree of orientational order was measured by means of the deuterium NMR technique performed on labelled network chains. The induced order increases with the density of crosslinking junctions and trapped entanglements. The observed effects are analysed versus the equilibrium swelling degree of the samples, in order to characterize the real network structure with respect to chain segment ordering.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01188357
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  • 5
    Electronic Resource
    Electronic Resource
    Strain-induced large fluctuations during stress relaxation in polymer melts observed by small-angle neutron scattering. “Lozenges”, “butterflies”, and related theory (1991)
    Springer
    Colloid & polymer science 269 (1991), S. 195-216 
    Details
    ISSN: 1435-1536
    Keywords: Polymer networks ; polymer melts ; polymer blends ; rubber ; deformation ; small-angle neutron scattering ; dynamics ; relaxation ; polystyrene ; crosslinking ; heterogeneities ; finite extensibility ; entanglements ; demixing ; segregation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract We discuss the neutron scattering features of melts containing a fraction of labeled chains, and of rubbers containing a fraction of deuterated paths along several successive elementary chains. Both types of material are studied during relaxation after a fast deformation in very similar conditions. An unusual feature is the shape of the anisotropic scattering as visualized on a bidimensional detector: the isointensity lines have the shape of lozenges. A detailed review of various cases makes this appear as a general feature in SANS scattering from melts and rubbers in a state of partially relaxed deformation. We then describe results for mixtures of small labeled chains inside matrices of large entangled chains or crosslinked matrices: we find another unusual shape of the isointensity levels, called “butterfly”. We propose the lozenges to be a combination of the classical elliptical scattering with a butterfly scattering, which has a main axis orthogonal to the main axis of the ellipses. We discuss in more details the origin of the butterfly effect, by following two tracks: the first is several theories about demixing under strain, including influence of the strain on the enthalpic, elastic, and conformational terms of the free energy of mixing. The second track is the influence of heterogeneities in crosslinked materials. An explanation which would be common to the case of crosslinked and uncrosslinked material remains to be established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00665493
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  • 6
    Electronic Resource
    Electronic Resource
    Synthèse de copolymères multiséquencés comportant des séquences cristallines organosiliciques (1989)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 165 (1989), S. 181-196 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Multiblock copolymers involving crystallizable blocks of poly(1-dimethylsilyl-4-dimethylethylenesilyl benzene) and blocks of either polystyrene (PS) or poly(ethyleneoxide) (PEO) were prepared by hydrosilylation reaction between α,ω-difunctional precursor polymers. The organosilicic precursor was fitted at both chain-ends with dimethylsilane functions. The reactive end groups of the PS or PEO precursors were silvinylic functions attached to the polymer chains through chemical groups of the same nature as the monomer unit of the crystallizable block. In this case, and under adequate stoichiometric conditions the hydrosilylation reaction between functional chain ends is possible and yields multiblock copolymers containing 6 to 10 blocks.
    Notes: Des copolymères multiséquencés comportant des séquences cristallisables de poly(diméthylsilyl-1 diméthyléthylènesilyl-4 benzène) et des séquences, soit de polystryrène (PS), soit de poly(oxyéthylène) (POE), ont été préparés par réaction d'hydrosilylation entre polymères précurseurs, α,ω-difonctionnels. Le polymère organosilicique utilisé portait des fonctions diméthylsilane aux deux extrémités de sa chaîne. Les polymères précurseurs PS et POE étaient dotés aux deux extrémités de leur chaîne de fonctions silvinyliques portées par un motif chimique de même nature que celle de l'unité monomère de la séquence organosilicique. Dans des conditions expérimentales adéquates, la réaction d'hydrosilylation conduit alors à des copolymères multiséquencés comportant 6 à 10 séquences.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1989.051650115
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  • 7
    Electronic Resource
    Electronic Resource
    Copolymerization in the crystalline solid state (1968)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Polymer Science: Macromolecular Reviews 3 (1968), S. 1-48 
    Details
    ISSN: 0076-2083
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 33 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1968.230030101
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  • 8
    Electronic Resource
    Electronic Resource
    Spectrum of light scattered from viscoelastic gels (1976)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 14 (1976), S. 1097-1109 
    Details
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Spectra of polarized light scattered from model networks of polystyrene swollen by benzene have been measured by optical mixing spectroscopy. Various series of networks of different functionalities and different lengths of the elastic chain elements have been investigated. A theoretical expression for the characteristic time constant of fluctuations has been derived from rubber elasticity theory. An analysis of the experimental results within the framework of this theory allows determination of the frictional constants of the gels.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1976.180140612
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  • 9
    Electronic Resource
    Electronic Resource
    Copolymerization of vinyl and cyclic monomers in the solid state (1967)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 110 (1967), S. 173-179 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Es wurde das polymere Produkt untersucht, das durch γ-Bestrahlung der sorgfältig getrckneten, eutektischen Mischungen von Styrol und β-Propiolacton erhalten wurde. Die Mischungen wurden wenige Grade unterhalb ihres Schmelzpunktes in evakuierten und abgeschmolzenen Gefäßen bestrahlt. Es wurden keine Copolymeren erhalten, sondern nur Gemische von Homopolyimeren. Im Falle der γ-Bestrahlung eines festen Gemisches von Acrylnitril und β-Propiolacton ergaben sich jedoch Hinweise, die eine frühere Behauptung, daß unter diesen Bedingungen Copolymere erhalten wurden, unterstützten.
    Notes: A study has been made of the polymeric product obtained by exposure to γ-rays of carefully dried eutectic mixtures of styrene and β-propiolactone which were sealed in vacuum and maintained at a few degrees below the melting point. No copolymer was formed, only a mixture of homopolymers. However, evidence was obtained which supports an earlier claim that a copolymer is formed by γ-irradiation of a solid mixture of acrylonitrile and β-propiolac tone.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1967.021100117
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  • 10
    Electronic Resource
    Electronic Resource
    The solid-state polymerization of trithiane (1966)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Letters 4 (1966), S. 995-997 
    Details
    ISSN: 0449-2986
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1966.110041215
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