Publikationsdatum:
2001-06-08
Beschreibung:
Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster controlled a highly pathogenic immunodeficiency virus challenge in a rhesus macaque model. Both the DNA and rMVA components of the vaccine expressed multiple immunodeficiency virus proteins. Two DNA inoculations at 0 and 8 weeks and a single rMVA booster at 24 weeks effectively controlled an intrarectal challenge administered 7 months after the booster. These findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the acquired immune deficiency syndrome epidemic.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Amara, R R -- Villinger, F -- Altman, J D -- Lydy, S L -- O'Neil, S P -- Staprans, S I -- Montefiori, D C -- Xu, Y -- Herndon, J G -- Wyatt, L S -- Candido, M A -- Kozyr, N L -- Earl, P L -- Smith, J M -- Ma, H L -- Grimm, B D -- Hulsey, M L -- Miller, J -- McClure, H M -- McNicholl, J M -- Moss, B -- Robinson, H L -- P01 AI 43045/AI/NIAID NIH HHS/ -- P30 DA 12121/DA/NIDA NIH HHS/ -- P51 RR000165/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2001 Apr 6;292(5514):69-74.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vaccine Research Center and Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30329, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11393868" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
AIDS Vaccines/administration & dosage/*immunology
;
Acquired Immunodeficiency Syndrome/immunology/*prevention & control/virology
;
Animals
;
Antibodies, Viral/blood/immunology
;
CD4-Positive T-Lymphocytes/immunology
;
CD8-Positive T-Lymphocytes/immunology
;
Germinal Center/immunology
;
HIV Antibodies/blood/immunology
;
HIV-1/genetics/immunology/physiology
;
Immunity, Mucosal
;
Immunization, Secondary
;
Immunologic Memory
;
Interferon-gamma/biosynthesis
;
Lymph Nodes/immunology
;
Macaca mulatta
;
SAIDS Vaccines/administration & dosage/immunology
;
Simian Acquired Immunodeficiency Syndrome/immunology/prevention &
;
control/virology
;
Simian Immunodeficiency Virus/genetics/immunology/physiology
;
T-Lymphocytes/immunology
;
Vaccines, DNA/administration & dosage/*immunology
;
Vaccines, Synthetic/administration & dosage/immunology
;
Vaccinia virus/immunology
;
Viral Load
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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