ISSN:
1420-9071
Keywords:
Epstein-Barr virus
;
tumor promoter
;
antitubulin agents
;
vinblastine
;
vincristine
;
anticancer agents
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary 28 anticancer agents have been surveyed for Epstein-Barr virus (EBV) activating potency. Two vinca alkaloids with antitubulin activity, vinblastine (VLB) and vincristine (VCR), enhanced the expression of EBV early antigens (EA) in a latently infected human lymphoblastoid cell line (Raji), when used in combination withn-butyrate. Other antitubulin agents, colchicine, colcemid, and podophyllotoxin, had the same effect, although their effects were less than that of the potent tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02004511
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