Summary
28 anticancer agents have been surveyed for Epstein-Barr virus (EBV) activating potency. Two vinca alkaloids with antitubulin activity, vinblastine (VLB) and vincristine (VCR), enhanced the expression of EBV early antigens (EA) in a latently infected human lymphoblastoid cell line (Raji), when used in combination withn-butyrate. Other antitubulin agents, colchicine, colcemid, and podophyllotoxin, had the same effect, although their effects were less than that of the potent tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA).
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This work was partly supported by grant-in-aid 57440072 from the Ministry of Education, Science and Culture, Japan. We thank Dr I. Luduig for reading the manuscript.
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Fujita, J., Yoshida, O., Tokuda, H. et al. Enhanced expression of Epstein-Barr virus early antigens by antitubulin agents in a latently infected human lymphoblastoid cell line. Experientia 41, 372–373 (1985). https://doi.org/10.1007/BF02004511
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DOI: https://doi.org/10.1007/BF02004511