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Granulocytosis induced in vivo by a mouse marrow stromal cell line, BMA1, which produces colony stimulating factor

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Nude mice were inoculated with BMA1 cells. These are cells which produce granulocyte-macrophage colony stimulating factor (GM-CSF); They are derived from mouse bone marrow stromal cells transfected with adenovirus 5 DNA. Progressive neutrophilia developed as the tumor grew, but disappeared quickly after local tumor excision. Media conditioned with tumor cells had GM-CSF but neither erythropoietin, nor burst-promoting activity. In all the tumors which developed, focal areas of bone formation were found among fibrosarcomatous tissues.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, National Defence Medical College, 359, Saitama, Japan

    K. Fujita, Y. Shimomura, J. Fujita & K. J. Mori

  2. Department of Microbiology, Faculty of Medicine, Kyoto University, 606, Kyoto, Japan

    K. Fujita, Y. Shimomura, J. Fujita & K. J. Mori

Authors
  1. K. Fujita
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  2. Y. Shimomura
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  3. J. Fujita
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  4. K. J. Mori
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Fujita, K., Shimomura, Y., Fujita, J. et al. Granulocytosis induced in vivo by a mouse marrow stromal cell line, BMA1, which produces colony stimulating factor. Experientia 41, 504–505 (1985). https://doi.org/10.1007/BF01966170

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  • DOI: https://doi.org/10.1007/BF01966170

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