ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
Your search history is empty.
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Springer  (12)
  • Nature Publishing Group (NPG)  (7)
  • Society of Economic Geologists (SEG)  (3)
  • 1
    facet.materialart.
    Unknown
    Genes mirror geography within Europe (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-09-02
    Description: Understanding the genetic structure of human populations is of fundamental interest to medical, forensic and anthropological sciences. Advances in high-throughput genotyping technology have markedly improved our understanding of global patterns of human genetic variation and suggest the potential to use large samples to uncover variation among closely spaced populations. Here we characterize genetic variation in a sample of 3,000 European individuals genotyped at over half a million variable DNA sites in the human genome. Despite low average levels of genetic differentiation among Europeans, we find a close correspondence between genetic and geographic distances; indeed, a geographical map of Europe arises naturally as an efficient two-dimensional summary of genetic variation in Europeans. The results emphasize that when mapping the genetic basis of a disease phenotype, spurious associations can arise if genetic structure is not properly accounted for. In addition, the results are relevant to the prospects of genetic ancestry testing; an individual's DNA can be used to infer their geographic origin with surprising accuracy-often to within a few hundred kilometres.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735096/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735096/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Novembre, John -- Johnson, Toby -- Bryc, Katarzyna -- Kutalik, Zoltan -- Boyko, Adam R -- Auton, Adam -- Indap, Amit -- King, Karen S -- Bergmann, Sven -- Nelson, Matthew R -- Stephens, Matthew -- Bustamante, Carlos D -- R01 GM083606/GM/NIGMS NIH HHS/ -- R01 GM083606-01/GM/NIGMS NIH HHS/ -- R01 GM083606-02/GM/NIGMS NIH HHS/ -- England -- Nature. 2008 Nov 6;456(7218):98-101. doi: 10.1038/nature07331. Epub 2008 Aug 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Interdepartmental Program in Bioinformatics, University of California-Los Angeles, Los Angeles, California 90095, USA. jnovembre@ucla.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18758442" target="_blank"〉PubMed〈/a〉
    Keywords: Emigration and Immigration ; Europe/ethnology ; Genetic Variation/*genetics ; *Genetics, Population ; Genome, Human/genetics ; Genome-Wide Association Study ; Genotype ; *Geography ; Humans ; Phylogeny ; Polymorphism, Single Nucleotide ; Principal Component Analysis ; Quantitative Trait, Heritable ; Sample Size
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Global landscape of HIV-human protein complexes (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-12-23
    Description: Human immunodeficiency virus (HIV) has a small genome and therefore relies heavily on the host cellular machinery to replicate. Identifying which host proteins and complexes come into physical contact with the viral proteins is crucial for a comprehensive understanding of how HIV rewires the host's cellular machinery during the course of infection. Here we report the use of affinity tagging and purification mass spectrometry to determine systematically the physical interactions of all 18 HIV-1 proteins and polyproteins with host proteins in two different human cell lines (HEK293 and Jurkat). Using a quantitative scoring system that we call MiST, we identified with high confidence 497 HIV-human protein-protein interactions involving 435 individual human proteins, with approximately 40% of the interactions being identified in both cell types. We found that the host proteins hijacked by HIV, especially those found interacting in both cell types, are highly conserved across primates. We uncovered a number of host complexes targeted by viral proteins, including the finding that HIV protease cleaves eIF3d, a subunit of eukaryotic translation initiation factor 3. This host protein is one of eleven identified in this analysis that act to inhibit HIV replication. This data set facilitates a more comprehensive and detailed understanding of how the host machinery is manipulated during the course of HIV infection.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310911/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310911/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jager, Stefanie -- Cimermancic, Peter -- Gulbahce, Natali -- Johnson, Jeffrey R -- McGovern, Kathryn E -- Clarke, Starlynn C -- Shales, Michael -- Mercenne, Gaelle -- Pache, Lars -- Li, Kathy -- Hernandez, Hilda -- Jang, Gwendolyn M -- Roth, Shoshannah L -- Akiva, Eyal -- Marlett, John -- Stephens, Melanie -- D'Orso, Ivan -- Fernandes, Jason -- Fahey, Marie -- Mahon, Cathal -- O'Donoghue, Anthony J -- Todorovic, Aleksandar -- Morris, John H -- Maltby, David A -- Alber, Tom -- Cagney, Gerard -- Bushman, Frederic D -- Young, John A -- Chanda, Sumit K -- Sundquist, Wesley I -- Kortemme, Tanja -- Hernandez, Ryan D -- Craik, Charles S -- Burlingame, Alma -- Sali, Andrej -- Frankel, Alan D -- Krogan, Nevan J -- P01 AI090935/AI/NIAID NIH HHS/ -- P01 AI090935-02/AI/NIAID NIH HHS/ -- P01 GM073732-05/GM/NIGMS NIH HHS/ -- P41 GM103481/GM/NIGMS NIH HHS/ -- P41 RR001081/RR/NCRR NIH HHS/ -- P41RR001614/RR/NCRR NIH HHS/ -- P50 GM081879/GM/NIGMS NIH HHS/ -- P50 GM081879-02/GM/NIGMS NIH HHS/ -- P50 GM082250/GM/NIGMS NIH HHS/ -- P50 GM082250-05/GM/NIGMS NIH HHS/ -- P50GM081879/GM/NIGMS NIH HHS/ -- P50GM082545/GM/NIGMS NIH HHS/ -- U54 RR022220/RR/NCRR NIH HHS/ -- England -- Nature. 2011 Dec 21;481(7381):365-70. doi: 10.1038/nature10719.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22190034" target="_blank"〉PubMed〈/a〉
    Keywords: Affinity Labels ; Amino Acid Sequence ; Conserved Sequence ; Eukaryotic Initiation Factor-3/chemistry/metabolism ; HEK293 Cells ; HIV Infections/metabolism/virology ; HIV Protease/metabolism ; HIV-1/*chemistry/*metabolism/physiology ; *Host-Pathogen Interactions ; Human Immunodeficiency Virus Proteins/analysis/chemistry/isolation & ; purification/*metabolism ; Humans ; Immunoprecipitation ; Jurkat Cells ; Mass Spectrometry ; Protein Binding ; Protein Interaction Mapping/*methods ; Protein Interaction Maps/*physiology ; Reproducibility of Results ; Virus Replication
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Understanding mechanisms underlying human gene expression variation with RNA sequencing (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-03-12
    Description: Understanding the genetic mechanisms underlying natural variation in gene expression is a central goal of both medical and evolutionary genetics, and studies of expression quantitative trait loci (eQTLs) have become an important tool for achieving this goal. Although all eQTL studies so far have assayed messenger RNA levels using expression microarrays, recent advances in RNA sequencing enable the analysis of transcript variation at unprecedented resolution. We sequenced RNA from 69 lymphoblastoid cell lines derived from unrelated Nigerian individuals that have been extensively genotyped by the International HapMap Project. By pooling data from all individuals, we generated a map of the transcriptional landscape of these cells, identifying extensive use of unannotated untranslated regions and more than 100 new putative protein-coding exons. Using the genotypes from the HapMap project, we identified more than a thousand genes at which genetic variation influences overall expression levels or splicing. We demonstrate that eQTLs near genes generally act by a mechanism involving allele-specific expression, and that variation that influences the inclusion of an exon is enriched within and near the consensus splice sites. Our results illustrate the power of high-throughput sequencing for the joint analysis of variation in transcription, splicing and allele-specific expression across individuals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089435/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089435/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pickrell, Joseph K -- Marioni, John C -- Pai, Athma A -- Degner, Jacob F -- Engelhardt, Barbara E -- Nkadori, Everlyne -- Veyrieras, Jean-Baptiste -- Stephens, Matthew -- Gilad, Yoav -- Pritchard, Jonathan K -- GM077959/GM/NIGMS NIH HHS/ -- MH084703-01/MH/NIMH NIH HHS/ -- R01 GM077959/GM/NIGMS NIH HHS/ -- R01 GM077959-05/GM/NIGMS NIH HHS/ -- R01 MH084703/MH/NIMH NIH HHS/ -- R01 MH084703-02/MH/NIMH NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Apr 1;464(7289):768-72. doi: 10.1038/nature08872. Epub 2010 Mar 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Human Genetics, The University of Chicago, Chicago 60637, USA. pickrell@uchicago.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20220758" target="_blank"〉PubMed〈/a〉
    Keywords: African Continental Ancestry Group/genetics ; Alleles ; Consensus Sequence/genetics ; DNA, Complementary/genetics ; Exons/genetics ; *Gene Expression Profiling ; Gene Expression Regulation/*genetics ; Genetic Variation/*genetics ; Humans ; Nigeria ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/genetics ; RNA Splice Sites/genetics ; RNA, Messenger/*analysis/*genetics ; Sequence Analysis, RNA ; Transcription, Genetic/*genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Animal research: replacing the lab rat (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-03-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stephens, Martin -- England -- Nature. 2011 Mar 24;471(7339):449. doi: 10.1038/471449c.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21430764" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Experimentation ; Animal Use Alternatives/*trends ; Animals ; *Animals, Laboratory ; Rats
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    DNase I sensitivity QTLs are a major determinant of human expression variation (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-02-07
    Description: The mapping of expression quantitative trait loci (eQTLs) has emerged as an important tool for linking genetic variation to changes in gene regulation. However, it remains difficult to identify the causal variants underlying eQTLs, and little is known about the regulatory mechanisms by which they act. Here we show that genetic variants that modify chromatin accessibility and transcription factor binding are a major mechanism through which genetic variation leads to gene expression differences among humans. We used DNase I sequencing to measure chromatin accessibility in 70 Yoruba lymphoblastoid cell lines, for which genome-wide genotypes and estimates of gene expression levels are also available. We obtained a total of 2.7 billion uniquely mapped DNase I-sequencing (DNase-seq) reads, which allowed us to produce genome-wide maps of chromatin accessibility for each individual. We identified 8,902 locations at which the DNase-seq read depth correlated significantly with genotype at a nearby single nucleotide polymorphism or insertion/deletion (false discovery rate = 10%). We call such variants 'DNase I sensitivity quantitative trait loci' (dsQTLs). We found that dsQTLs are strongly enriched within inferred transcription factor binding sites and are frequently associated with allele-specific changes in transcription factor binding. A substantial fraction (16%) of dsQTLs are also associated with variation in the expression levels of nearby genes (that is, these loci are also classified as eQTLs). Conversely, we estimate that as many as 55% of eQTL single nucleotide polymorphisms are also dsQTLs. Our observations indicate that dsQTLs are highly abundant in the human genome and are likely to be important contributors to phenotypic variation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501342/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501342/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Degner, Jacob F -- Pai, Athma A -- Pique-Regi, Roger -- Veyrieras, Jean-Baptiste -- Gaffney, Daniel J -- Pickrell, Joseph K -- De Leon, Sherryl -- Michelini, Katelyn -- Lewellen, Noah -- Crawford, Gregory E -- Stephens, Matthew -- Gilad, Yoav -- Pritchard, Jonathan K -- HG006123/HG/NHGRI NIH HHS/ -- MH084703/MH/NIMH NIH HHS/ -- MH090951/MH/NIMH NIH HHS/ -- R01 HG006123/HG/NHGRI NIH HHS/ -- R01 HG006123-01/HG/NHGRI NIH HHS/ -- R01 HG006123-02/HG/NHGRI NIH HHS/ -- R01 MH090951/MH/NIMH NIH HHS/ -- R01 MH090951-01/MH/NIMH NIH HHS/ -- R01 MH090951-02/MH/NIMH NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Feb 5;482(7385):390-4. doi: 10.1038/nature10808.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22307276" target="_blank"〉PubMed〈/a〉
    Keywords: Chromatin/genetics/metabolism ; *DNA Footprinting ; Deoxyribonuclease I/*metabolism ; Gene Expression Profiling ; Gene Expression Regulation/*genetics ; Genetic Variation/*genetics ; Genome, Human/genetics ; Humans ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/*genetics ; Sequence Analysis, DNA ; Transcription Factors/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    A statin-dependent QTL for GATM expression is associated with statin-induced myopathy (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-09-03
    Description: Statins are prescribed widely to lower plasma low-density lipoprotein (LDL) concentrations and cardiovascular disease risk and have been shown to have beneficial effects in a broad range of patients. However, statins are associated with an increased risk, albeit small, of clinical myopathy and type 2 diabetes. Despite evidence for substantial genetic influence on LDL concentrations, pharmacogenomic trials have failed to identify genetic variations with large effects on either statin efficacy or toxicity, and have produced little information regarding mechanisms that modulate statin response. Here we identify a downstream target of statin treatment by screening for the effects of in vitro statin exposure on genetic associations with gene expression levels in lymphoblastoid cell lines derived from 480 participants of a clinical trial of simvastatin treatment. This analysis identified six expression quantitative trait loci (eQTLs) that interacted with simvastatin exposure, including rs9806699, a cis-eQTL for the gene glycine amidinotransferase (GATM) that encodes the rate-limiting enzyme in creatine synthesis. We found this locus to be associated with incidence of statin-induced myotoxicity in two separate populations (meta-analysis odds ratio = 0.60). Furthermore, we found that GATM knockdown in hepatocyte-derived cell lines attenuated transcriptional response to sterol depletion, demonstrating that GATM may act as a functional link between statin-mediated lowering of cholesterol and susceptibility to statin-induced myopathy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933266/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933266/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mangravite, Lara M -- Engelhardt, Barbara E -- Medina, Marisa W -- Smith, Joshua D -- Brown, Christopher D -- Chasman, Daniel I -- Mecham, Brigham H -- Howie, Bryan -- Shim, Heejung -- Naidoo, Devesh -- Feng, QiPing -- Rieder, Mark J -- Chen, Yii-Der I -- Rotter, Jerome I -- Ridker, Paul M -- Hopewell, Jemma C -- Parish, Sarah -- Armitage, Jane -- Collins, Rory -- Wilke, Russell A -- Nickerson, Deborah A -- Stephens, Matthew -- Krauss, Ronald M -- HG002585/HG/NHGRI NIH HHS/ -- K99/R00HG006265/HG/NHGRI NIH HHS/ -- MC_U137686853/Medical Research Council/United Kingdom -- P30 DK063491/DK/NIDDK NIH HHS/ -- R00 HG006265/HG/NHGRI NIH HHS/ -- R01 HG002585/HG/NHGRI NIH HHS/ -- R01 HL104133/HL/NHLBI NIH HHS/ -- U01 HL069757/HL/NHLBI NIH HHS/ -- U01 HL69757/HL/NHLBI NIH HHS/ -- UL1 TR000124/TR/NCATS NIH HHS/ -- British Heart Foundation/United Kingdom -- Medical Research Council/United Kingdom -- England -- Nature. 2013 Oct 17;502(7471):377-80. doi: 10.1038/nature12508. Epub 2013 Aug 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sage Bionetworks, 1100 Fairview Avenue North, Seattle, Washington 98109, USA. lara.mangravite@sagebase.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23995691" target="_blank"〉PubMed〈/a〉
    Keywords: Amidinotransferases/deficiency/*genetics/metabolism ; Cell Line ; Cholesterol/deficiency/metabolism/pharmacology ; Gene Expression Regulation/*drug effects ; Gene Knockdown Techniques ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/*adverse effects/pharmacology ; Lymphocytes/cytology/drug effects/metabolism ; Muscular Diseases/*chemically induced/genetics/metabolism ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/*genetics ; Simvastatin/*adverse effects/pharmacology ; Sterol Regulatory Element Binding Proteins/metabolism ; Transcription, Genetic/drug effects
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Mangravite et al. reply (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-09-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mangravite, Lara M -- Engelhardt, Barbara E -- Stephens, Matthew -- Krauss, Ronald M -- England -- Nature. 2014 Sep 18;513(7518):E3. doi: 10.1038/nature13630.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sage Bionetworks, Seattle, Washington 98109, USA. ; 1] Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA [2] Present address: Biostatistics and Bioinformatics Department and Department of Statistical Science, Duke University, Durham, North Carolina 27708, USA. ; 1] Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA [2] Department of Statistics, University of Chicago, Chicago, Illinois 60637, USA. ; Children's Hospital Research Institute, Oakland, California 94609, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25230670" target="_blank"〉PubMed〈/a〉
    Keywords: Amidinotransferases/*genetics ; Gene Expression Regulation/*drug effects ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/*adverse effects ; Muscular Diseases/*chemically induced ; Quantitative Trait Loci/*genetics ; Simvastatin/*adverse effects
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    Electronic Resource
    Electronic Resource
    Chronology of eclogite retrogression within the Seve Nappe Complex, Råvvejaure, Sweden: Evidence from40Ar/39Ar mineral ages (1991)
    Springer
    International journal of earth sciences 80 (1991), S. 729-743 
    Details
    ISSN: 1437-3262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract Amphibole concentrates from four samples of variably retrogressed eclogite from the Tsäkkok Lens of the Seve Nappe Complex display discordant40Ar/39Ar age spectra suggestive of extraneous argon contamination.36Ar/40Ar vs.39Ar/40Ar isotope correlations are well-defined for two samples and yield ages of 464.7 ± 1.3 Ma and 463.2 + 6.3 Ma. Inverse ordinate intercepts are very much larger than 295 and confirm significant extraneous argon components. Two white mica concentrates from metasedimentary units of the Tsäkkok Lens display internally concordant40Ar/39Ar age spectra which define plateau ages of 448.2 ± 1.6 Ma and 468.4 ± 0.9 Ma. An amphibole concentrate from a metamorphosed basic dike within the Sarek Lens of the Seve Nappe Complex yields an isotope correlation age of 463.8 ± 12.3 Ma, suggesting a post-metamorphic thermal evolution similar to that of the Tsäkkok Lens. The amphibolite and white mica ages are interpreted to date post-metamorphic cooling through appropriate temperatures for intracrystalline retention of argon following amphibolite facies retrogression of the eclogite facies assemblages. The Seve Nappe Complex appears to have originated within distal facies of the late Proterozoic-early Paleozoic miogeocline of Baltica. The present40Ar/39Ar results provide a record of early Paleozoic (pre-Middle Ordovician) tectonothermal activity and therefore are compatible with previous suggestions of significant early Caledonian orogenesis within the Scandinavian Caledonides.
    Abstract: Résumé Les concentrés d'amphiboles de quatre échantillons d'éclogites, rétromorphosés à des degrés divers, provenant de la lentille de Träkkok («Seve Nappe Complex») montre un spectre discordant d'âges40Ar/39Ar, ce qui suggère une contamination par un apport d'argon. Les corrélations entre36Ar/40Ar et39Ar/40Ar sont bien définies pour deux échantillons et fournissent des âges de 464,7 ± 1,3 Ma et 463,2 ±6,3 Ma. Les rapports40Ar/36Ar sont beaucoup plus élevés que 295 et confirment un apport extérieur d'argon significatif. Deux concentrés de mica blanc provenant des unités métasédimentaires de la lentille de Tsäkkok présentent des spectres d'âges40Ar/39Ar concordants, qui définissent des âges-plateau de 448,2 ± 1,6 Ma et 468,4 ± 0,9 Ma. Un concentré d'amphibole provenant d'un dyke basique métamorphisé dans la lentille des Sarek du «Seve Nappe Complex» fournit par corrélation isotopique un âge de 463,8 ± 12,9 Ma, ce qui suggère une évolution thermique post-métamorphique similaire à celle de la lentille de Tsäkkok. Les âges fournis par les amphiboles et les micas blancs sont interprétés comme correspondant au refroidissement post-métamorphique, à travers des températures permettant la rétention intracristalline de l'argon, à la suite de la rétromorphose des éclogites dans le faciès des amphiboles. Le «Seve Nappe Complex» a dû être engendré dans les faciès distaux du miogéosynclinal tardi-protérozoïque à éo-paléozoïque de la Baltique. Les valeurs actuelles de40Ar/39Ar enregistrent l'activité tectonothermique du Paléozoïque inférieur (pré-Ordovicien moyen); elles sont donc en accord avec l'hypothèse antérieurement émise d'une orogenèse éo-calédonienne au sein des Calédonides Scandinaves.
    Notes: Zusammenfassung Die Amphibolitkonzentrate aus vier Proben unterschiedlich regressiver Eklogite aus der Tsäkkok-Linse des Seve-Deckenkomplexes spiegeln diskordante40Ar/39Ar Altersspektren wieder. Diese deuten an, daß eine Argonkontamination von außen stattgefunden hat.36Ar/40Ar gegen39Ar/40Ar Isotopen sind für zwei Proben genau bestimmt und liefern Alter von 464,7 ± 1,3 Mio. und 463,2 ± 6,3 Mio. Jahre. Inverse Ordinatenabschnitte sind sehr viel größer als 295 und bestätigen erhebliche Argon-Fremdkomponenten. Zwei Hellglimmerkonzentrate aus metasedimentären Einheiten der Tsäkkok-Linse zeigen intern konkordante40Ar/39Ar Altersspektren, welche Plateaualter von 448,2 ± 1,6 Mio. und 468,4 ± 0,9 Mio. Jahre besitzen. Ein Amphibolkonzentrat aus einem metamorphen basischen Gang innerhalb der Sarek-Linse des Seve-Deckenkomplexes liefert ein Isotopenkorrelationsalter von 463,8 ±12,3 Mio. Jahre, welches eine postmetamorphe thermale Entwicklung andeutet, die ähnlich der Tsäkkok-Linse ist. Die Amphibol- und Hellglimmeralter werden dahingehend interpretiert, daß sie die postmetamorphe thermale Abkühlung durch entsprechende Temperaturen für das intrakristalline Zurückhalten des Argons datieren, die im Anschluß an die Amphibolitfaziesregression der Eklogitfaziesvergesellschaftung folgte. Der Seve-Deckenkomplex scheint aus einer distalen Fazies spätprotero- bis frühpalaeozoischen Miogeosynklinale von Baltika hervorgegangen zu sein. Die jetzigen40Ar/39Ar Ergebnisse liefern eine Aufzeichnung von frühpaleozoischen (Vor-Mittelordovizium) tektono-thermalen Aktivitäten, und sie sind daher vergleichbar mit früheren Vermutungen von einer bedeutenden frühkaledonischen Orogenese innerhalb der skandinavischen Kaledoniden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01803698
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Pillow lavas as protoliths for eclogites: evidence from a late Precambrian-Cambrian continental margin, Seve Nappes, Scandinavian Caledonides (1990)
    Springer
    Contributions to mineralogy and petrology 105 (1990), S. 1-10 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Pillow lavas containing an eclogitic mineral assemblage, locally with glaucophane/crossite, are described from the Tsäkkok Lens within the Seve Nappes, north-central Scandinavian Caledonides. Critical primary relationships to the host metasedimentary rocks which are dominated by marble and quartz-garnet-phengite schist are preserved. It is argued that these clastic rocks, and the ongoing igneous activity in the Tsäkkok Lens, are late Precambrian to Cambrian in age and that these rocks were deposited/emplaced along the outermost part of a continental margin related to the continent Baltica. Variations in the whole-rock chemistry of the eclogitic rocks within the Tsäkkok Lens suggest that most elements were mobile during post-extrusive/intrusive evolution. Only Ti, P and Y show significant magmatic trends in element vs Zr plots. Discriminant diagrams employing the elements Ti, P, Zr, Y, Nb and Cr suggest a tholeiitic protolith with a tendency towards enriched mid-ocean ridge basalt (E-MORB) affinity characterized by a relatively low Zr/Nb ratio. A similarity to metabasic rocks occurring in other Seve thrust sheets but lacking evidence for high-P metamorphism is apparent. A common origin for all these rocks is inferred. The Tsäkkok eclogites formed by ‘in situ’ high-P metamorphism and provide further evidence for subduction of continental crustal material down to mantle depths. This subduction event has been related to collision of Baltica with an outboard are system during the late Cambrian to early Ordovician.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320962
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Acute effects of short-term subcutaneous terbutaline on theophylline disposition (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 191-193 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; terbutaline ; pharmacokinetics ; asthma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Theophylline and subcutaneous terbutaline are frequently used concurrently in the management of acute asthma. Recent evidence demonstrating a reduction in theophylline serum concentrations during concomitant oral terbutaline therapy prompted our evaluation of subcutaneous terbutaline's effect on theophylline pharmacokinetics. Using a randomized, placebo controlled, crossover design, the disposition of a single oral theophylline dose (7 mg/kg) was studied in eight healthy, adult males before and after repeated subcutaneous administration of terbutaline (0.25 mg). Two-way analysis of variance revealed no significant difference in elimination rate constant (ke), area under the concentration-time curve (AUC), or apparent oral clearance (CL/F) of theophylline following terbutaline administration. These results indicate that subcutaneous administration of terbutaline does not alter the pharmacokinetics of single, oral doses of theophylline in adults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542194
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...