Publication Date:
2018-05-05
Description:
Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology Generation of 〈i〉App〈/i〉 knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology, Published online: 04 May 2018; doi:10.1038/s41467-018-04238-0 To date, only one mutation in the gene for amyloid-beta precursor protein APP has been suggested to be protective against Alzheimer’s disease. Here, authors found using gene editing of a mutant App knock-in mouse line that deletion of the 3’UTR region is protective against amyloid-β accumulation in vivo, and subsequently identify a 52-bp element in the 3’UTR region that is responsible for this effect.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
Permalink