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  • Springer  (453)
  • Institute of Physics  (338)
  • Public Library of Science  (112)
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  • 1
    ISSN: 1432-0827
    Keywords: Key words: Colles' fracture — Osteoporotic fractures — Type I osteoporosis — Postmenopausal women — Corticoendosteal bone loss.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Based on the hypothesis that the underlying osteoporotic mechanism of Colles' fracture in postmenopausal women is similar to that of other osteoporotic fractures, that is, cortical bone resorption as opposed to cancellous bone resorption, the rate of corticoendosteal bone loss was compared in 40 normal postmenopausal women [average age 68.4 ± 7.1 years; 20 ± 4 years since menopause (YSM)], in 35 postmenopausal women with Colles' fracture (age 69.4 ± 7.5 years, 22 ± 8 YSM), in 35 normal postmenopausal women with vertebral crush fracture (age 69.4 ± 7.5 years, 22 ± 8 YSM, and in 35 normal premenopausal women (age 36.1 ± 7.9 years). Radiogrammetry by digital radiography of the second metacarpal was used to measure external (ED) and internal (ID) diameter, cortical thickness (CCT), cortical area (CA), and the ratio of cortical area to total area (CA/TA). The ID values of the groups of postmenopausal women were subtracted from the ID value of the premenopausal women and the result was divided by YSM to obtain the rate of corticoendosteal resorption/year (ΔC), CA resorption year (ΔCA) and CA/TA resorption/year (ΔCA/TA). ID, ΔC, ΔCA, and ΔCA/TA all were larger in the postmenopausal women with Colles' and vertebral crush fractures than in the normal postmenopausal women (ANOVA: all P 〈 0.0001). ID, CCT, ΔC, CA, ΔCA, and ΔCA/TA did not differ between the two groups of postmenopausal women with fractures. ΔC was 87% greater in postmenopausal women with vertebral crush fracture and 116% greater in women with Colles' fracture than in normal postmenopausal women. These results indicate that the loss of cortical bone is an important factor in Colles' fracture in postmenopausal women.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 60 (1997), S. 567 -570 
    ISSN: 1432-0827
    Keywords: Key words: Colles' fracture — Calcitonin — Calcium — Radiogrammetry.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. In 45 women with Colles' fracture, two types of complementary medical treatment (calcitonin with calcium [SCT+Ca] and calcium alone [Ca]) were compared with placebo. Consecutive patients were assigned randomly to one of the three study groups at the time of inclusion in the study: 15 women (68.6 ± 5.7 years) were given 100 IU/day I.M. of SCT plus 1200 mg of elemental Ca for 10 successive days each month; 15 women (71.7 ± 6.1 years) were given only 1200 mg of elemental Ca for 10 days each month; and 15 women (66.9 ± 7.9 years) were treated with placebo. Biochemical and radiogrammetric studies were made at baseline and after 1 year of treatment. In the SCT+Ca group tartrate-resistant acid phosphatase decreased (Wilcoxon test, P= 0.014) and the metacarpal index and the cortical and total area (CA/TA) ratio increased (both P= 0.001). In the group treated with Ca alone, no changes were observed. In the placebo group, the metacarpal index and CA/TA decreased (P= 0.015 and P= 0.007, respectively). Ca alone, at the dosage used here, inhibited bone loss after Colles' fracture. The addition of SCT to Ca administration not only impeded bone loss but significantly increased cortical bone mass.
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  • 3
    Publication Date: 2021-03-31
    Electronic ISSN: 2515-7655
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Institute of Physics
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  • 4
    ISSN: 1432-2048
    Keywords: Carboxylating enzymes ; C4 photosynthesis ; Photosynthesis (C3-C4) ; Zea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The activities of the carboxylating enzymes ribulose-1,5-biphosphate (RuBP) carboxylase and phosphoenolpyruvate (PEP) carboxylase in leaves of three-week old Zea mays plants grown under phytotron conditions were found to vary according to leaf position. In the lower leaves the activity of PEP carboxylase was lower than that of RuBP carboxylase, while the upper leaves exhibited high levels of PEP carboxylase. Carbon dioxide compensation points and net photosynthetic rates also differed in the lower and upper leaves. Differences in the fine structure of the lowermost and uppermost leaves are shown. The existence of both the C3 and C4 photosynthetic pathways in the same plant, in this and other species, is discussed.
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  • 5
    ISSN: 1432-0827
    Keywords: Key words: Bone metabolism — Bone remodeling markers — Marathon — High performance exercise.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Bone metabolism parameters were studied in 18 elite marathon runners (11 men and 7 women) who participated in the Marathon World Cup held at San Sebastian, Spain in 1993. Measurements were made before the race, immediately after the race, and 24 hours after the race. The most interesting finding was increased alkaline phosphatase (P 〈 0.0001) and decreased tartrate-resistant acid phosphatase (P= 0.0035), which suggests that exercise produced uncoupling of the bone cell metabolism. Serum calcium corrected for proteins did not increase with exercise and at the end of the race there was a negative correlation between cortisol, which was significantly higher (P 〈 0.0001), and corrected serum calcium (r = 0.53, P= 0.026) that was not present at baseline. Running time showed a significant negative correlation with baseline serum cortisol (r =−0.67, P= 0.0015) and a significant positive correlation with body mass index (r = 0.53, P= 0.0207). The increase in alkaline phosphatase persisted 24 hours after the race, which suggests that exercise produced an intense and sustained effect on osteogenic capacity.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Archiv der Mathematik 53 (1989), S. 270-276 
    ISSN: 1420-8938
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 57 (2000), S. 1613-1636 
    ISSN: 1420-9071
    Keywords: Key words. Ras; cell cycle; differentiation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The Ras family of small GTPases includes three closely related proteins: H-, K-, and N-Ras. Ras proteins are involved in the transduction of signals elicited by activated surface receptors, acting as key components by relaying signals downstream through diverse pathways. Mutant, constitutively activated forms of Ras proteins are frequently found in cancer. While constitutive Ras activation induces oncogenic-like transformation in immortalized fibroblasts, it causes growth arrest in primary vertebrate cells. Induction of p53 and cyclin-dependent kinase inhibitors such as p15INK4b, p16INK4a, p19ARF, and p21WAF1 accounts for this response. Interestingly, while ras has usually been regarded as a transforming oncogene, the analysis of Ras function in most of the cellular systems studied so far indicates that the promotion of differentiation is the most prominent effect of Ras. While in some cell types, particularly muscle, Ras inhibits differentiation, in others such as neuronal, adipocytic, or myeloid cells, Ras induces differentiation, in some cases accompanied by growth arrest. Several possible mechanisms for the pleiotropic effects of Ras in animal cells are discussed.
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  • 8
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A strain of Lactobacillus plantarum, DSMZ 12028 (Deutsch Sammlung von Mikroorganismen und Zellkulturen), isolated from a Portuguese dry fermented sausage, “chouriço”, was found to produce true lipase, producing free fatty acids from triolein (olive oil). This enzymatic activity was found in whole cells, but was negligible in comparison to lipolytic activity in culture supernatant. Therefore, only extracellular activity was studied. The effect of pH, temperature and glucose concentration on extracellular lipase production was studied in continuously stirred tank reactors, the first time this technology has been used to study the production of this enzyme in lactobacilli. Maximum lipase production was achieved at a pH of 5.5 and 30 °C and was kept at a significant level over a wide range of dilution rates (0.05–0.4 h−1); the production of lipase was still significant for low pH values, temperature and glucose concentration, conditions that are close to the ones present during chouriço ripening. The effect of glucose concentration was also studied in a batch system. The control of lipase production was found to be related both to glucose concentration in the medium and to the growth rate/dilution rate. Glucose concentration was found to be important for fast lipase production, although it did not influence the maximum lipase activity reached in a batch culture.
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  • 9
    ISSN: 1432-0630
    Keywords: PACS: 61.80.-x; 68.35.Rh; 81.40.-z
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract.  During 350 keV Ar+ irradiation at 77 K, laser-deposited Fe–Ag multilayers first show stress relaxation and demixing processes at the interfaces followed by grain coarsening and a supersaturation of the bcc α-Fe phase with Ag due to ballistic mixing. At high fluences, the fcc γ-Fe(Ag) phase (a=3.65 AÅ) is formed, which can be explained by either chemically guided ballistic short-range relocations or by the occurrence of thermal spikes, where all atoms possess sufficient energy to allow collective structural rearrangements, but only during such a short time that a decomposition due to long-range diffusion is suppressed.
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  • 10
    ISSN: 1432-0630
    Keywords: 61.80.-x ; 68.35.Rh ; 81.40.-z
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract During 350 keV Ar+ irradiation at 77K, laser-deposited Fe−Ag multilayers first show stress relaxation and demixing processes at the interfaces followed by grain coarsening and a supersaturation of the bcc α-Fe phase with Ag due to ballistic mixing. At high fluence, the fcc γ-Fe(Ag) phase (a=3.65 Å) is formed, which can be explained by either chemically guided ballistic short-range relocations or by the occurrence of thermal spikes, where all atoms possess sufficient energy to allow collective structural rearrangements, but only during such a short time that a decomposition due to long-range diffusion is suppressed.
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