ISSN:
1432-0827
Keywords:
Key words: Colles' fracture — Calcitonin — Calcium — Radiogrammetry.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
,
Physics
Notes:
Abstract. In 45 women with Colles' fracture, two types of complementary medical treatment (calcitonin with calcium [SCT+Ca] and calcium alone [Ca]) were compared with placebo. Consecutive patients were assigned randomly to one of the three study groups at the time of inclusion in the study: 15 women (68.6 ± 5.7 years) were given 100 IU/day I.M. of SCT plus 1200 mg of elemental Ca for 10 successive days each month; 15 women (71.7 ± 6.1 years) were given only 1200 mg of elemental Ca for 10 days each month; and 15 women (66.9 ± 7.9 years) were treated with placebo. Biochemical and radiogrammetric studies were made at baseline and after 1 year of treatment. In the SCT+Ca group tartrate-resistant acid phosphatase decreased (Wilcoxon test, P= 0.014) and the metacarpal index and the cortical and total area (CA/TA) ratio increased (both P= 0.001). In the group treated with Ca alone, no changes were observed. In the placebo group, the metacarpal index and CA/TA decreased (P= 0.015 and P= 0.007, respectively). Ca alone, at the dosage used here, inhibited bone loss after Colles' fracture. The addition of SCT to Ca administration not only impeded bone loss but significantly increased cortical bone mass.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002239900281
