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  • American Institute of Physics (AIP)  (5)
  • Wiley  (3)
  • Hindawi  (1)
  • 1
    Publication Date: 2012-06-21
    Description: Autophagy provides a mechanism for the turnover of cellular organelles and proteins through a lysosome-dependent degradation pathway. During starvation, autophagy exerts a homeostatic function that promotes cell survival by recycling metabolic precursors. Additionally, autophagy can interact with other vital processes such as programmed cell death, inflammation, and adaptive immune mechanisms, and thereby potentially influence disease pathogenesis. Macrophages deficient in autophagic proteins display enhanced caspase-1-dependent proinflammatory cytokine production and the activation of the inflammasome. Autophagy provides a functional role in infectious diseases and sepsis by promoting intracellular bacterial clearance. Mutations in autophagy-related genes, leading to loss of autophagic function, have been implicated in the pathogenesis of Crohn's disease. Furthermore, autophagy-dependent mechanisms have been proposed in the pathogenesis of several pulmonary diseases that involve inflammation, including cystic fibrosis and pulmonary hypertension. Strategies aimed at modulating autophagy may lead to therapeutic interventions for diseases associated with inflammation.
    Print ISSN: 1687-8876
    Electronic ISSN: 1687-8884
    Topics: Biology
    Published by Hindawi
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 74 (1993), S. 1456-1458 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A material for thermally stable self-aligned silicide technologies has been developed using sequentially deposited Ti/Ta on polycrystalline silicon. At lower annealing temperatures below 1000 °C two separate phases were found by cross-sectional transmission electron microscopy to exist in the form of bilayer TiSi2/TaSi2. The formation of a ternary phase (TiTa)Si2 has been observed at a higher temperature of 1000 °C. Consequently, the ternary (TiTa)Si2 layer could be kept extremely flat, with a sheet resistance of 5 Ω/(D'Alembertian), even after 1000 °C, 30 min annealing. Cross-sectional transmission electron micrographs of the structure clearly reveal that no agglomeration occurs during the heat treatment.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 72 (1992), S. 297-299 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The formation of titanium silicides on Si implanted with different BF2+ dosages has been studied by secondary ion mass spectrometry and transmission electron microscopy measurements. The thickness of the silicide layer formed in the temperature ranging from 600 to 800 °C has been investigated as a function of the implanted BF2+ dosage up to 1×1016 cm−2. Annealing at 700 °C results in conversion of the titanium film into predominantly C49 TiSi2, and most of it is transformed into the C54 phase at 800 °C or higher, resulting in a lower sheet resistance (16 μΩ cm). The titanium silicide thickness formed after the rapid thermal annealing (RTA) treatment depends on the implanted BF2+ dosage, caused by the native oxide enhanced by increased damage. Boron is redistributed into the silicide layer up to the solid solubility limit during annealing, leading to an accumulation at the silicide/silicon interface. The lowest contact resistance (with a size of 0.7 μm×0.7 μm) of 35 Ω is obtained at the annealing temperature of 700 °C.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Using metalorganic chemical vapor deposition assisted by a nitrogen radical irradiation generated by rf plasma, we have enhanced the quality and the step coverage of titanium nitride barrier metals for the contact holes with a high aspect ratio and a submicron radius. Electrical resistivity measurements show that the film resistivity improves by a factor of five as the proper nitrogen irradiation has been applied. The step coverage in a contact hole with 0.4 μm diam and 3:1 aspect ratio has been improved from 50% to 80% by applying nitrogen plasma, clearly demonstrating the effectiveness of this technique in the conformal deposition of barrier metals for the ultra-large scale integration. The incident nitrogen radical is believed to play several roles, such as the enhancement of surface migration rate of molecules and the reduction of the amount of hydrocarbon incorporating into the film during the deposition. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Oxygen diffusion/incorporation behaviors of TiN/Ti/Si structures after thermal annealing in nitrogen ambients have been studied by x-ray photoelectron spectroscopy and cross-sectional transmission electron microscopy measurements. At the interface between Ti and TiN, titanium dioxides, thermodynamically most stable, are formed as a consequence of grain boundary diffusion, while inside TiN layer the contents of TiO and Ti2O3 compounds increases as the annealing temperature increases. At the interface between Ti and Si, titanium silicide formation is observed in the samples annealed above 450 °C consuming a part of pure Ti layer. One thing to note is that a severe blistering is observed in a sample annealed at 600 °C, probably caused by the difference of thermal expansion coefficients between TiSi2 and TiO2.
    Type of Medium: Electronic Resource
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  • 6
    Publication Date: 2015-05-09
    Description: We investigate an electron flux dropout during a weak storm on November 7–8, 2008, with Dst minimum value being −37 nT. During this period, two clear dropouts were observed on GOES-11 〉 2MeV electrons. We also find a simultaneous dropout in the sub-relativistic electrons recorded by THEMIS probes in the outer radiation belt. Using the Radiation Belt Environment (RBE) model, we try to reproduce the observed dropout features in both relativistic and sub-relativistic electrons. We found that there are local time dependences in the dropout for both observation and simulation in sub-relativistic electrons; (1) particle loss begins from nightside and propagates into dayside, and (2) resupply starts from near dawn MLT and propagates into the dayside following electron drift direction. That resupply of the particles might be caused by substorm injections due to enhanced convection. We found a significant precipitation in hundreds keV electrons during the dropout. We observe electromagnetic ion cyclotron (EMIC) and chorus waves both on the ground and in space. We find the drift shells are opened near the beginning of the first dropout. The dropout in MeV electrons at GEO might therefore be initiated due to the magnetopause shadowing and the followed dropout in hundreds keV electrons might be the result of the combination of magnetopause shadowing and precipitation loss into the earth's atmosphere.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 7
    Publication Date: 2015-06-18
    Description: We review a powerful regularization method, known as CONTIN, for obtaining the size distribution of colloidal suspensions from dynamic light scattering data. We show that together with the so-called L-curve criterion for selecting the optimal regularization parameter, the method correctly describes the average size and size distribution of microgel suspensions independently characterized using small-angle neutron scattering. In contrast, we find that when using the default regularization process, where the regularizer is selected via the “probability to reject” method, the results are not as satisfactory.
    Print ISSN: 0021-9606
    Electronic ISSN: 1089-7690
    Topics: Chemistry and Pharmacology , Physics
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  • 8
    Publication Date: 2019
    Description: Abstract Non‐Darcy flow (also known as high‐velocity flow, inertial flow, etc.) often occurs in the near‐well region of a reservoir during injection or production. This flow needs to be characterized and its origins fully understood, as it is a critical factor in reducing well productivity. The Forchheimer equation, which describes fluid flow considering an inertial effect, can be adopted to analyze non‐Darcy flow. In particular, the non‐Darcy coefficient in the equation represents inertial resistance in a porous medium and is an empirical value that depends on the pore geometry and fluid properties. This study, as part of research on geological CO2 storage, reports non‐Darcy flow tests with a high flow rate and examines the non‐Darcy coefficient by using supercritical CO2 and various sandstones. The dependence of the coefficient on the properties of the supercritical CO2 was also assessed in a series of non‐Darcy tests under different pore pressures. The coefficient varied with the properties of the supercritical CO2 and sandstone. As the permeability of sandstone increased, the non‐Darcy coefficient decreased nonlinearly and converged to a value. The results also indicate that the coefficient is reduced with a decreasing ratio of density to viscosity for the supercritical CO2. An equation predicting the coefficient was derived, having the advantage that both the hydraulic properties of rock and the fluid properties can be considered simultaneously in a dimensionally correct analysis.
    Print ISSN: 2169-9313
    Electronic ISSN: 2169-9356
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 9
    Publication Date: 1988-01-01
    Print ISSN: 0002-1962
    Electronic ISSN: 1435-0645
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Wiley
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