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  • American Association for the Advancement of Science (AAAS)  (3)
  • American Institute of Physics (AIP)  (2)
  • Blackwell Publishing Ltd  (2)
  • 1
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    Developmental control of plant Rho GTPase nano-organization by the lipid phosphatidylserine (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉Rho guanosine triphosphatases (GTPases) are master regulators of cell signaling, but how they are regulated depending on the cellular context is unclear. We found that the phospholipid phosphatidylserine acts as a developmentally controlled lipid rheostat that tunes Rho GTPase signaling in 〈i〉Arabidopsis〈/i〉. Live superresolution single-molecule imaging revealed that the protein Rho of Plants 6 (ROP6) is stabilized by phosphatidylserine into plasma membrane nanodomains, which are required for auxin signaling. Our experiments also revealed that the plasma membrane phosphatidylserine content varies during plant root development and that the level of phosphatidylserine modulates the quantity of ROP6 nanoclusters induced by auxin and hence downstream signaling, including regulation of endocytosis and gravitropism. Our work shows that variations in phosphatidylserine levels are a physiological process that may be leveraged to regulate small GTPase signaling during development.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Deep human genealogies reveal a selective advantage to be on an expanding wave front (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-11-05
    Description: Since their origin, human populations have colonized the whole planet, but the demographic processes governing range expansions are mostly unknown. We analyzed the genealogy of more than one million individuals resulting from a range expansion in Quebec between 1686 and 1960 and reconstructed the spatial dynamics of the expansion. We find that a majority of the present Saguenay Lac-Saint-Jean population can be traced back to ancestors having lived directly on or close to the wave front. Ancestors located on the front contributed significantly more to the current gene pool than those from the range core, likely due to a 20% larger effective fertility of women on the wave front. This fitness component is heritable on the wave front and not in the core, implying that this life-history trait evolves during range expansions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moreau, Claudia -- Bherer, Claude -- Vezina, Helene -- Jomphe, Michele -- Labuda, Damian -- Excoffier, Laurent -- New York, N.Y. -- Science. 2011 Nov 25;334(6059):1148-50. doi: 10.1126/science.1212880. Epub 2011 Nov 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre de Recherche, Hopital Sainte-Justine, Universite de Montreal, 3175 Cote Sainte-Catherine, Montreal, Quebec, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22052972" target="_blank"〉PubMed〈/a〉
    Keywords: *Demography ; Emigration and Immigration ; Family Characteristics ; Female ; Fertility ; *Gene Pool ; Genes ; *Genetic Fitness ; Humans ; Male ; Marriage ; *Pedigree ; *Population Dynamics ; Quebec ; Registries ; Reproduction ; *Selection, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    Fabrication and magnetic characterization of single domain Co91Fe9 nanostructures (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 6316-6318 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Linear arrays of 15 nm thick, polycrystalline Co91Fe9 nanoelements have been fabricated using e-beam lithography, collimated sputtering and lift-off. The elements have widths of 0.17 and 0.25 μm, lengths from 0.5 to 4 μm, pointed ends, and center-to-center spacing of 0.5 μm. Characterization by magnetic force microscopy shows that in the virgin state these elements are single-domain and have magnetizations parallel to their long axes. The field at which an element switches its magnetization direction is shown to depend mainly on its width, and only slightly on its length. Fields of about 440 and 680 Oe are needed to switch completely the 0.25 and 0.17 μm structures, respectively. This separation in switching fields is adequate to allow elements of different widths to be switched independently. Also, magnetic force microscopy and SQUID magnetometry analysis show that a capping layer is necessary to protect the films from oxidation. Unprotected films show an altered hysteresis loop and their associated nanostructures are not consistently single-domain. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.372691
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  • 4
    Electronic Resource
    Electronic Resource
    Measurements of the diffusion rate of lithium in aluminum at low temperature by elastic recoil detection analysis (1985)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 58 (1985), S. 4582-4586 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The diffusion coefficient of lithium in aluminum has been investigated as a function of temperature between 150 and 240 °C by elastic recoil detection analysis. This dependence is found to be well described by the following expression: D =0.37(+1.30−0.28)exp{−[(126.1 ±5.2)kJ/ mol/RT]} cm2/s.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.336250
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  • 5
    Electronic Resource
    Electronic Resource
    Phylogeny of flatfishes (Pleuronectiformes): comparisons and contradictions of molecular and morpho-anatomical data (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 45 (1994), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Several species of flatfishes (Pleuronectiformes) have been studied by isoenzyme electrophoresis and DNA/DNA hybridization to establish the evolutionary relationships of this group of fishes. This molecular data-based phylogeny has been compared to previously described phylogenies based on morpho-anatomical criteria. A number of discrepancies are observed and discussed. The high degree of genetic divergence observed within the families of Pleuronectiformes indicates that their origin seems to be much older than suggested by their striking morphological similarity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1994.tb00934.x
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  • 6
    Electronic Resource
    Electronic Resource
    ANALYSIS OF HLA HAPLOTYPES IN FAMILIES WITH TYPE 1 DIABETES MELLITUS IN LA RÉUNION ISLAND (1996)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 23 (1996), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: To analyse HLA and insulin-dependent diabetes mellitus (IDDM) association in the ethnically mixed population of La Réunion island, we carried out a family study on 70 diabetic subjects. HLA-DQA1, -DQB1 and -DRB1 typing was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), completed by PCR-sequence-specific oligonucleotide (SSO) and PCR-sequence-specific priming (SSP). Haplotype-relative risks (HRR) were determined with the non-transmitted parental haplotypes as controls, and relative risks (RR) were calculated with a classical case-control study. The most significant risks were found for the cis and trans combinations between DQA1*03 or *0501 (Arg52+) and DQB1*02 or *0302 (Asp57−) alleles, suggesting a direct role for the HLA-DQ heterodimer in IDDM susceptibility. Interestingly, due to the mixed origin of the population, the trans-encoded DQ molecules in the (DR3)-DQA1*0501-DQB1*02/(DR4)-DQA1*03-DQB 1*0302 subjects were also found cis-encoded in patients with the (DR7 or 9)-DQA1*03-DQB1*02 haplotype and in a patient with the rare (DR 11)-DQA1*0501-DQB 1*0302 haplotype. A relative predispositional effect (RPE) analysis gave significant haplotype-IDDM+ associations in the following order: (DR3)-DQA1*0501-DQB1*02〉(DR4)-DQA1*03-DQB1*0302〉(DR9)-DQA1*03-DQB*02〉(DR7)-DQA1*03-DQB1*02〉(DR2)-DQA1*01-DQB1*0502. No protective effect remained significant once the susceptible haplotypes were removed. A stratification study showed a stronger influence of the DQ genes than DRB1 alleles within the DR7 haplotypes. On the other hand, IDDM subjects with only one susceptible haplotype had inherited this haplotype more often from their father than from their mother. This paternal effect could be related to the greater risk of IDDM in offspring of diabetic fathers than the risk in offspring of diabetic mothers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1996.tb00136.x
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  • 7
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    Will DNA barcoding meet taxonomic needs? (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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