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  • Oxford University Press  (6)
  • American Association for the Advancement of Science (AAAS)  (3)
  • American Institute of Physics (AIP)  (2)
  • American Chemical Society (ACS)  (1)
  • 1
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    Probing the reactivity of singlet oxygen with purines (2016)
    Oxford University Press
    Details
    Publication Date: 2016-01-09
    Description: The reaction of singlet molecular oxygen with purine DNA bases is investigated by computational means. We support the formation of a transient endoperoxide for guanine and by classical molecular dynamics simulations we demonstrate that the formation of this adduct does not affect the B-helicity. We thus identify the guanine endoperoxide as a key intermediate, confirming a low-temperature nuclear magnetic resonance proof of its existence, and we delineate its degradation pathway, tracing back the preferential formation of 8-oxoguanine versus spiro-derivates in B-DNA. Finally, the latter oxidized 8-oxodGuo product exhibits an almost barrierless reaction profile, and hence is found, coherently with experience, to be much more reactive than guanine itself. On the contrary, in agreement with experimental observations, singlet-oxygen reactivity onto adenine is kinetically blocked by a higher energy transition state.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 2
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    Tuning the Architecture of Cellulose Nanocrystal–Poly(allylamine hydrochloride) Multilayered Thin Films: Influence of Dipping Parameters (2012)
    American Chemical Society (ACS)
    In: Langmuir
    Details
    Publication Date: 2012-07-04
    Description: Langmuir DOI: 10.1021/la301293r
    Print ISSN: 0743-7463
    Electronic ISSN: 1520-5827
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 3
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    Developmental control of plant Rho GTPase nano-organization by the lipid phosphatidylserine (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉Rho guanosine triphosphatases (GTPases) are master regulators of cell signaling, but how they are regulated depending on the cellular context is unclear. We found that the phospholipid phosphatidylserine acts as a developmentally controlled lipid rheostat that tunes Rho GTPase signaling in 〈i〉Arabidopsis〈/i〉. Live superresolution single-molecule imaging revealed that the protein Rho of Plants 6 (ROP6) is stabilized by phosphatidylserine into plasma membrane nanodomains, which are required for auxin signaling. Our experiments also revealed that the plasma membrane phosphatidylserine content varies during plant root development and that the level of phosphatidylserine modulates the quantity of ROP6 nanoclusters induced by auxin and hence downstream signaling, including regulation of endocytosis and gravitropism. Our work shows that variations in phosphatidylserine levels are a physiological process that may be leveraged to regulate small GTPase signaling during development.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Concordance of gene expression in human protein complexes reveals tissue specificity and pathology (2013)
    Oxford University Press
    Details
    Publication Date: 2013-10-08
    Description: Disease-causing variants in human genes usually lead to phenotypes specific to only a few tissues. Here, we present a method for predicting tissue specificity based on quantitative deregulation of protein complexes. The underlying assumption is that the degree of coordinated expression among proteins in a complex within a given tissue may pinpoint tissues that will be affected by a mutation in the complex and coordinated expression may reveal the complex to be active in the tissue. We identified known disease genes and their protein complex partners in a high-quality human interactome. Each susceptibility gene's tissue involvement was ranked based on coordinated expression with its interaction partners in a non-disease global map of human tissue-specific expression. The approach demonstrated high overall area under the curve (0.78) and was very successfully benchmarked against a random model and an approach not using protein complexes. This was illustrated by correct tissue predictions for three case studies on leptin, insulin-like-growth-factor 2 and the inhibitor of NF-B kinase subunit gamma that show high concordant expression in biologically relevant tissues. Our method identifies novel gene-phenotype associations in human diseases and predicts the tissues where associated phenotypic effects may arise.
    Keywords: Computational Methods, Genomics, Miscellaneous/other
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 5
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    Deep human genealogies reveal a selective advantage to be on an expanding wave front (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-11-05
    Description: Since their origin, human populations have colonized the whole planet, but the demographic processes governing range expansions are mostly unknown. We analyzed the genealogy of more than one million individuals resulting from a range expansion in Quebec between 1686 and 1960 and reconstructed the spatial dynamics of the expansion. We find that a majority of the present Saguenay Lac-Saint-Jean population can be traced back to ancestors having lived directly on or close to the wave front. Ancestors located on the front contributed significantly more to the current gene pool than those from the range core, likely due to a 20% larger effective fertility of women on the wave front. This fitness component is heritable on the wave front and not in the core, implying that this life-history trait evolves during range expansions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moreau, Claudia -- Bherer, Claude -- Vezina, Helene -- Jomphe, Michele -- Labuda, Damian -- Excoffier, Laurent -- New York, N.Y. -- Science. 2011 Nov 25;334(6059):1148-50. doi: 10.1126/science.1212880. Epub 2011 Nov 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre de Recherche, Hopital Sainte-Justine, Universite de Montreal, 3175 Cote Sainte-Catherine, Montreal, Quebec, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22052972" target="_blank"〉PubMed〈/a〉
    Keywords: *Demography ; Emigration and Immigration ; Family Characteristics ; Female ; Fertility ; *Gene Pool ; Genes ; *Genetic Fitness ; Humans ; Male ; Marriage ; *Pedigree ; *Population Dynamics ; Quebec ; Registries ; Reproduction ; *Selection, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Analysis of surface and seismic sources in dense array data with match field processing and Markov chain Monte Carlo sampling (2019)
    Oxford University Press
    Details
    Publication Date: 2019
    Description: 〈span〉〈div〉SUMMARY〈/div〉We introduce a methodology based on array processing to detect and locate weak seismic events in a complex fault zone environment. The method is illustrated using data recorded by a dense array of 1108 vertical component geophones in a 600 m × 600 m area on the Clark branch of the San Jacinto Fault. Because surface and atmospheric sources affect weak ground motion, it is necessary to discriminate them from weak seismic sources at depth. Source epicentral positions and associated apparent velocities are extracted from continuous seismic waveforms using Match Field Processing (MFP). We implement MFP at specific frequencies targeting surface and subsurface sources, using for computational efficiency a forward model of acoustic source in a homogenous medium and Markov Chain Monte Carlo sampling. Surface sources such as Betsy gun shots and a moving vehicle are successfully located. Weak seismic events are also detected outside of the array, and their backazimuth angle is retrieved and found to be consistent with the fault geometry. We also show that the homogeneous acoustic model does not yield satisfying results when extracting microseismic event depth, because of the ambiguity between depth and the apparent velocity based on surface data.〈/span〉
    Print ISSN: 2051-1965
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 7
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    Analysis of surface and seismic sources in dense array data with Match Field Processing and Markov Chain Monte Carlo sampling (2019)
    Oxford University Press
    Details
    Publication Date: 2019
    Description: 〈span〉〈div〉Summary〈/div〉We introduce a methodology based on array processing to detect and locate weak seismic events in a complex fault zone environment. The method is illustrated using data recorded by a dense array of 1108 vertical component geophones in a 600 m x 600 m area on the Clark branch of the San Jacinto Fault. Because surface and atmospheric sources affect weak ground motion, it is necessary to discriminate them from weak seismic sources at depth. Source epicentral positions and associated apparent velocities are extracted from continuous seismic waveforms using Match Field Processing (MFP). We implement MFP at specific frequencies targeting surface and subsurface sources, using for computational efficiency a forward model of acoustic source in a homogenous medium and Markov-Chain Monte Carlo sampling. Surface sources such as Betsy gun shots and a moving vehicle are successfully located. Weak seismic events are also detected outside of the array, and their back-azimuth angle is retrieved and found to be consistent with the fault geometry. We also show that the homogeneous acoustic model does not yield satisfying results when extracting micro-seismic event depth, because of the ambiguity between depth and the apparent velocity based on surface data.〈/span〉
    Print ISSN: 2051-1965
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 8
    Electronic Resource
    Electronic Resource
    Fabrication and magnetic characterization of single domain Co91Fe9 nanostructures (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 6316-6318 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Linear arrays of 15 nm thick, polycrystalline Co91Fe9 nanoelements have been fabricated using e-beam lithography, collimated sputtering and lift-off. The elements have widths of 0.17 and 0.25 μm, lengths from 0.5 to 4 μm, pointed ends, and center-to-center spacing of 0.5 μm. Characterization by magnetic force microscopy shows that in the virgin state these elements are single-domain and have magnetizations parallel to their long axes. The field at which an element switches its magnetization direction is shown to depend mainly on its width, and only slightly on its length. Fields of about 440 and 680 Oe are needed to switch completely the 0.25 and 0.17 μm structures, respectively. This separation in switching fields is adequate to allow elements of different widths to be switched independently. Also, magnetic force microscopy and SQUID magnetometry analysis show that a capping layer is necessary to protect the films from oxidation. Unprotected films show an altered hysteresis loop and their associated nanostructures are not consistently single-domain. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.372691
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  • 9
    Electronic Resource
    Electronic Resource
    Measurements of the diffusion rate of lithium in aluminum at low temperature by elastic recoil detection analysis (1985)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 58 (1985), S. 4582-4586 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The diffusion coefficient of lithium in aluminum has been investigated as a function of temperature between 150 and 240 °C by elastic recoil detection analysis. This dependence is found to be well described by the following expression: D =0.37(+1.30−0.28)exp{−[(126.1 ±5.2)kJ/ mol/RT]} cm2/s.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.336250
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  • 10
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    Will DNA barcoding meet taxonomic needs? (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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