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  • Articles  (232)
  • Mice  (232)
  • 1980-1984  (232)
  • Medicine  (232)
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  • Articles  (232)
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  • 1
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    L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-02
    Description: The highly selective, enzyme-activated, irreversible inhibitor of L-ornithine decarboxylase, DL-alpha-difluoromethylornithine, suppresses the increase in uterine L-ornithine decarboxylase activity associated with early embryogenesis in the mouse and arrests embryonic development at that stage. Contragestational effects were confirmed in the rat and rabbit. An increase in L-ornithine decarboxylase activity that leads to a rapid increase in putrescine concentration appears to be essential during a critical period after implantation for continued mammalian embryonal growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fozard, J R -- Part, M L -- Prakash, N J -- Grove, J -- Schechter, P J -- Sjoerdsma, A -- Koch-Weser, J -- New York, N.Y. -- Science. 1980 May 2;208(4443):505-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6768132" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosylmethionine Decarboxylase/metabolism ; Animals ; Carboxy-Lyases/*physiology ; Eflornithine ; Embryo, Mammalian/drug effects/*physiology ; Female ; Gestational Age ; Mice ; Ornithine/*analogs & derivatives/pharmacology ; Ornithine Decarboxylase/*physiology ; Ornithine Decarboxylase Inhibitors ; Polyamines/metabolism ; Pregnancy ; Rabbits ; Rats ; Uterus/drug effects/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Prenatal exposure to the herbicide 2,4-dichlorophenyl-p-nitrophenyl ether destroys the rodent Harderian gland (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-15
    Description: Exposure of mice to the herbicide 2,4-dichlorophenyl-p-nitrophenyl ether during gestation produces abnormalities that are not readily apparent at birth but become obvious as the pups mature. By 2 weeks after birth there are severe intraorbital defects resulting from destruction of the Harderian glands behind the eyes. This effect is noticeable only postnatally because the Harderian gland does not grow or function until after birth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gray, L E Jr -- Kavlock, R J -- Chernoff, N -- Ferrell, J -- McLamb, J -- Ostby, J -- New York, N.Y. -- Science. 1982 Jan 15;215(4530):293-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053576" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*pathology ; Animals ; Female ; Harderian Gland/abnormalities/*drug effects ; Lacrimal Apparatus/*drug effects ; Male ; Mice ; Phenyl Ethers/*toxicity ; Pregnancy ; Rats ; Thyroxine/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Human cell hybrids: analysis of transformation and tumorigenicity (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-15
    Description: Intraspecific human-human cell hybrids provide a stable model system with which to investigate the genetic control of transformed and tumorigenic phenotypes. Using this system it has been shown that these phenotypes are under separate genetic control. Furthermore, the tumorigenic phenotype can be complemented by fusion of different tumorigenic cells, resulting in nontumorigenic hybrids. This system also provides information on the control of differentiated function. Molecular cytogenetic techniques should reveal the nature of the chromosomal control of neoplastic transformation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stanbridge, E J -- Der, C J -- Doersen, C J -- Nishimi, R Y -- Peehl, D M -- Weissman, B E -- Wilkinson, J E -- CA09054/CA/NCI NIH HHS/ -- CA19401/CA/NCI NIH HHS/ -- GM07134/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Jan 15;215(4530):252-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053574" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cell Transformation, Neoplastic/*pathology ; Cell Transformation, Viral ; Cells, Cultured ; Fibronectins/metabolism ; Humans ; *Hybrid Cells/pathology ; Karyotyping ; Mice ; Mice, Nude ; Neoplasms/*genetics/pathology ; Neoplasms, Experimental/pathology ; Phenotype
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Erythroid differentiation of clonal Rauscher erythroleukemia cells in response to erythropoietin or dimethyl sulfoxide (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-03
    Description: Clonal lines of Rauscher erythroleukemia cells exhibited selective responses to two inducers of differentiation, erythropoietin and dimethyl sulfoxide. There were substantial quantitiative differences between clones that reponded to both inducers. Several clones differentiated only in response to erythropoietin. Erythropoietin stimulated cell proliferation and differentiation whereas dimethyl sulfoxide inhibited proliferation, suggesting dissimilar modes of action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sytkowski, A J -- Salvado, A J -- Smith, G M -- McIntyre, C J -- deBoth, N J -- CA-18662/CA/NCI NIH HHS/ -- CA-26105/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 3;210(4465):74-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6932101" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/*drug effects ; Cell Division/drug effects ; Clone Cells/drug effects ; Dimethyl Sulfoxide/*pharmacology ; Erythropoietin/*pharmacology ; Hemoglobins/biosynthesis ; Leukemia, Erythroblastic, Acute/*pathology ; Leukemia, Experimental/pathology ; Mice ; Rauscher Virus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Genes for growth hormone, chorionic somatommammotropin, and growth hormones-like gene on chromosome 17 in humans (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: The human genes for growth hormone (GH), chorionic somatomammotropin (CSH), and a third growth hormone-like gene (GHL) have been located on chromosome 17 in humans. DNA fragments of 2.6, 2.8, and 9.5 kilobase pairs containing GH, CSH, and GHL, respectively, were identified in human genomic DNA, and a 7.5-kilobase DNA fragment related to growth hormone DNA sequences was found in mouse cells. In somatic hybrids of human and mouse cells containing reduced numbers of human chromosomes, but a normal complement of mouse chromosomes, the mouse, 7.5-kolobase DNA fragment was always present, whereas the 2.6-, 2.8-, and 9.5-kilobase human fragments were present only when human chromosome 17 was also present.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Owerbach, D -- Rutter, W J -- Martial, J A -- Baxter, J D -- Shows, T B -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):289-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384802" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Line ; *Chromosomes, Human, 16-18 ; *DNA/metabolism ; *Genes ; Growth Hormone/*biosynthesis ; Humans ; Hybrid Cells/metabolism ; Mice ; Placental Lactogen/*biosynthesis ; Translocation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Mating and pregnancy can occur in genetically hypogonadal mice with preoptic area brain grafts (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: Adult female hypogonadal mice, in whom hypogonadism is secondary to a genetic deficiency in hypothalamic gonadotropin-releasing hormone (GnRH), are infertile. Mating, pregnancy, and delivery of healthy litters were achieved after transplantation of normal fetal preoptic area tissue, a major site of GnRH-containing cell bodies, into the third ventricle of adult female hypogonadal mice. Immunocytochemistry revealed GnRH-containing neurons in the grafts and GnRH-containing processes extending to the lateral median eminence of the host brains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibson, M J -- Krieger, D T -- Charlton, H M -- Zimmerman, E A -- Silverman, A J -- Perlow, M J -- 1RO1NS20335/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):949-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6382608" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Chemistry ; Cerebral Ventricles/pathology ; *Copulation ; Female ; Hypogonadism/genetics/pathology/*physiopathology ; Infertility, Female/etiology/*therapy ; Male ; Mice ; Neurons/analysis ; Ovulation ; Pituitary Hormone-Releasing Hormones/analysis/*deficiency ; Pregnancy ; Preoptic Area/*transplantation ; *Reproduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Gut reactions of radioactive nitrite after intratracheal administration in mice (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-09
    Description: Intratracheal administration to mice of radioactive nitrite labeled with nitrogen-13 (13NO2-) (half-life, 9.96 minutes) in dosages that do not cause pharmacological perturbation reveals that oxidative and reductive reactions occur in different organs. Oxidation of 13NO2- to radioactive nitrate (13NO3-) predominates in the blood and liver. Reduction of 13NO2- occurs in those mice that harbor intestinal microflora; this reduction does not occur in germ-free mice. The intestinal reduction products include ammonium, glutamate, glutamine, and urea. With a detection limit of about 0.01 percent of the instilled nitrogen-13, no labeled nitrosamines were detected within 30 minutes. Reduced nitrogen-13 is transported out of the intensive into the circulatory system and appears in the urine along with 13NO3-. The biological half-period for 13NO2- destruction is about 7 minutes, and both oxidation and reduction products are formed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thayer, J R -- Chasko, J H -- Swartz, L A -- Parks, N J -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):151-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6211766" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Half-Life ; Intestines/*metabolism/microbiology ; Intubation, Intratracheal ; Mice ; Mice, Inbred BALB C ; Nitrites/administration & dosage/*metabolism ; Nitrogen Radioisotopes ; Oxidation-Reduction ; Specific Pathogen-Free Organisms ; Tissue Distribution
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Inherited primary hypothyroidism in mice (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: A new autosomal recessive mutation that causes hypothyroidism has been identified in mice. The gene, herein named hypothyroid (hyt), has been mapped on chromosome 12 approximately 30 units from the centromere. The mutants are characterized by retarded growth, infertility, mild anemia, elevated serum cholesterol, very low to undetectable serum thyroxine, and elevated serum thyroid-stimulating hormone. Thyroid glands are in the normal location but are reduced in size and hypoplastic. Mutant mice respond to thyroid hormone therapy by improved growth and fertility. These findings suggest that the hyt mutant gene results in primary hypothyroidism unresponsive to thyroid-stimulating hormone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beamer, W J -- Eicher, E M -- Maltais, L J -- Southard, J L -- AM-17947/AM/NIADDK NIH HHS/ -- NS-09378/NS/NINDS NIH HHS/ -- RR-01138/RR/NCRR NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):61-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209519" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia/etiology ; Animals ; Cholesterol/blood ; Chromosome Mapping ; Crosses, Genetic ; Female ; Genes, Recessive ; Humans ; Hypothyroidism/blood/*genetics/veterinary ; Male ; Mice ; Mice, Mutant Strains/*genetics ; Rodent Diseases/genetics ; Thyroid Gland/pathology ; Thyrotropin/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Nitrogen-13-labeled nitrite and nitrate: distribution and metabolism after intratracheal administration (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: Radioactive nitrogen-13 from nitrite (NO2-) or nitrate (NO3-) administered intratracheally or intravenously without added carrier to mice or rabbits was distributed evenly throughout most organs and tissues regardless of the entry route or the anion administered. Nitrogen-13 from both anions was distributed uniformly between plasma and blood cells. We found rapid in vivo oxidation of NO2- to NO3- at concentrations of 2 to 3 nanomoles per liter in blood. Over 50 percent oxidation within 10 minutes accounted for the similar nitrogen-13 distributions from both parent ions. The oxidation rates were animal species-dependent. No reduction of 13NO3- to 13NO2- was observed. A mechanistic hypothesis invoking oxidation of 13NO2- by a catalase-hydrogen peroxide complex accounts for the results. These results imply a concentration dependence for the in vivo fate of NO2- or nitrogen dioxide.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parks, N J -- Krohn, K J -- Mathis, C A -- Chasko, J H -- Geiger, K R -- Gregor, M E -- Peek, N F -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):58-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209517" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromatography, High Pressure Liquid ; Injections, Intravenous ; Mice ; Mice, Inbred BALB C ; Nitrates/administration & dosage/*metabolism ; Nitrites/administration & dosage/*metabolism ; Nitrogen Isotopes ; Oxidation-Reduction ; Rabbits ; Species Specificity ; Tissue Distribution ; Trachea
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    A virally induced obesity syndrome in mice (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-02
    Description: An obesity syndrome was found in a number of mice infected as young adults with canine distemper virus, a morbillivirus antigenically related to measles. Body weights of obese animals 16 to 20 weeks after infection were comparable to those reported for genetically obese mice and for mice rendered obese by hypothalamic lesions. The total number of adipocytes in specific fat deposits was greater in obese animals than in their lean littermates. This hyperplasia was accompanied by moderate cell enlargement. Pancreatic islet tissue was also hypercellular in the obese mice. Brain tissue from the obese mice showed no overt pathology, and immunofluorescence staining for viral antigens was negative. There may be a selective, virus-induced disruption of critical brain catecholamine pathways.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lyons, M J -- Faust, I M -- Hemmes, R B -- Buskirk, D R -- Hirsch, J -- Zabriskie, J B -- AM 20508/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 2;216(4541):82-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7038878" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/pathology ; Animals ; Brain/pathology ; Distemper/*pathology ; Distemper Virus, Canine ; Dogs ; Islets of Langerhans/pathology ; Mice ; Obesity/*microbiology/pathology ; Sex Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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