Publication Date:
1981-04-03
Description:
A new autosomal recessive mutation that causes hypothyroidism has been identified in mice. The gene, herein named hypothyroid (hyt), has been mapped on chromosome 12 approximately 30 units from the centromere. The mutants are characterized by retarded growth, infertility, mild anemia, elevated serum cholesterol, very low to undetectable serum thyroxine, and elevated serum thyroid-stimulating hormone. Thyroid glands are in the normal location but are reduced in size and hypoplastic. Mutant mice respond to thyroid hormone therapy by improved growth and fertility. These findings suggest that the hyt mutant gene results in primary hypothyroidism unresponsive to thyroid-stimulating hormone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beamer, W J -- Eicher, E M -- Maltais, L J -- Southard, J L -- AM-17947/AM/NIADDK NIH HHS/ -- NS-09378/NS/NINDS NIH HHS/ -- RR-01138/RR/NCRR NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):61-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209519" target="_blank"〉PubMed〈/a〉
Keywords:
Anemia/etiology
;
Animals
;
Cholesterol/blood
;
Chromosome Mapping
;
Crosses, Genetic
;
Female
;
Genes, Recessive
;
Humans
;
Hypothyroidism/blood/*genetics/veterinary
;
Male
;
Mice
;
Mice, Mutant Strains/*genetics
;
Rodent Diseases/genetics
;
Thyroid Gland/pathology
;
Thyrotropin/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
