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Enhanced expression of Epstein-Barr virus early antigens by antitubulin agents in a latently infected human lymphoblastoid cell line (1985)

Fujita, J. ; Yoshida, O. ; Tokuda, H. ; [et al.]

Springer

Cellular and molecular life sciences 41 (1985), S. 372-373

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ISSN: 1420-9071

Keywords: Epstein-Barr virus ; tumor promoter ; antitubulin agents ; vinblastine ; vincristine ; anticancer agents

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary 28 anticancer agents have been surveyed for Epstein-Barr virus (EBV) activating potency. Two vinca alkaloids with antitubulin activity, vinblastine (VLB) and vincristine (VCR), enhanced the expression of EBV early antigens (EA) in a latently infected human lymphoblastoid cell line (Raji), when used in combination withn-butyrate. Other antitubulin agents, colchicine, colcemid, and podophyllotoxin, had the same effect, although their effects were less than that of the potent tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA).

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02004511

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Granulocytosis induced in vivo by a mouse marrow stromal cell line, BMA1, which produces colony stimulating factor (1985)

Fujita, K. ; Shimomura, Y. ; Fujita, J. ; [et al.]

Springer

Cellular and molecular life sciences 41 (1985), S. 504-505

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ISSN: 1420-9071

Keywords: BMA1 cell line ; colony stimulating factor ; bone marrow stromal cell ; bone formation

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Nude mice were inoculated with BMA1 cells. These are cells which produce granulocyte-macrophage colony stimulating factor (GM-CSF); They are derived from mouse bone marrow stromal cells transfected with adenovirus 5 DNA. Progressive neutrophilia developed as the tumor grew, but disappeared quickly after local tumor excision. Media conditioned with tumor cells had GM-CSF but neither erythropoietin, nor burst-promoting activity. In all the tumors which developed, focal areas of bone formation were found among fibrosarcomatous tissues.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01966170

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